The Role of Exosomal Non-Coding RNAs in Coronary Artery Disease
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide. Atherosclerosis (AS) is a major cause of CVD. Oxidative stress, endothelial dysfunction, and inflammation are key factors involved in the development and progression of AS. Exosomes are nano-sized vesicles s...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2020.603104/full |
| _version_ | 1818919577948520448 |
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| author | Jia Liu Junduo Wu Longbo Li Tianyi Li Junnan Wang |
| author_facet | Jia Liu Junduo Wu Longbo Li Tianyi Li Junnan Wang |
| author_sort | Jia Liu |
| collection | DOAJ |
| description | Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide. Atherosclerosis (AS) is a major cause of CVD. Oxidative stress, endothelial dysfunction, and inflammation are key factors involved in the development and progression of AS. Exosomes are nano-sized vesicles secreted into the extracellular space by most types of cells, and are ideal substances for the transmission and integration of signals between cells. Cells can selectively encapsulate biologically active substances, such as lipids, proteins and RNA in exosomes and act through paracrine mechanisms. Non-coding RNAs (ncRNAs) are important for communication between cells. They can reach the recipient cells through exosomes, causing phenotypic changes and playing a molecular regulatory role in cell function. Elucidating their molecular mechanisms can help identify therapeutic targets or strategies for CVD. Coronary artery disease (CAD) is the most important disease in CVD. Here, we review the role and the regulatory mechanism of exosomal ncRNAs in the pathophysiology of CAD, as well as the potential contribution of exosomal ncRNA to diagnosis and treatment of CAD. |
| first_indexed | 2024-12-20T01:08:05Z |
| format | Article |
| id | doaj.art-fd3e938c202c4ce487fb27943e5af80e |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-20T01:08:05Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-fd3e938c202c4ce487fb27943e5af80e2022-12-21T19:58:47ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-12-011110.3389/fphar.2020.603104603104The Role of Exosomal Non-Coding RNAs in Coronary Artery DiseaseJia LiuJunduo WuLongbo LiTianyi LiJunnan WangCardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide. Atherosclerosis (AS) is a major cause of CVD. Oxidative stress, endothelial dysfunction, and inflammation are key factors involved in the development and progression of AS. Exosomes are nano-sized vesicles secreted into the extracellular space by most types of cells, and are ideal substances for the transmission and integration of signals between cells. Cells can selectively encapsulate biologically active substances, such as lipids, proteins and RNA in exosomes and act through paracrine mechanisms. Non-coding RNAs (ncRNAs) are important for communication between cells. They can reach the recipient cells through exosomes, causing phenotypic changes and playing a molecular regulatory role in cell function. Elucidating their molecular mechanisms can help identify therapeutic targets or strategies for CVD. Coronary artery disease (CAD) is the most important disease in CVD. Here, we review the role and the regulatory mechanism of exosomal ncRNAs in the pathophysiology of CAD, as well as the potential contribution of exosomal ncRNA to diagnosis and treatment of CAD.https://www.frontiersin.org/articles/10.3389/fphar.2020.603104/fullexosomesNon-coding RNAscoronary artery diseaseatherosclerosisacute myocardial infarction |
| spellingShingle | Jia Liu Junduo Wu Longbo Li Tianyi Li Junnan Wang The Role of Exosomal Non-Coding RNAs in Coronary Artery Disease Frontiers in Pharmacology exosomes Non-coding RNAs coronary artery disease atherosclerosis acute myocardial infarction |
| title | The Role of Exosomal Non-Coding RNAs in Coronary Artery Disease |
| title_full | The Role of Exosomal Non-Coding RNAs in Coronary Artery Disease |
| title_fullStr | The Role of Exosomal Non-Coding RNAs in Coronary Artery Disease |
| title_full_unstemmed | The Role of Exosomal Non-Coding RNAs in Coronary Artery Disease |
| title_short | The Role of Exosomal Non-Coding RNAs in Coronary Artery Disease |
| title_sort | role of exosomal non coding rnas in coronary artery disease |
| topic | exosomes Non-coding RNAs coronary artery disease atherosclerosis acute myocardial infarction |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2020.603104/full |
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