Behind the developing brains and beating hearts of stem cell-derived embryo models
Studies over the past decade have shown how stem cells representing embryonic and extra-embryonic tissues of the mouse can self-assemble in the culture dish to recapitulate an astonishing part of early embryonic development. A systematic analysis has demonstrated how pluripotent embryonic stem cells...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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The Royal Society
2023-01-01
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| Series: | Open Biology |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/10.1098/rsob.220325 |
| _version_ | 1797785695209652224 |
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| author | Gianluca Amadei David M. Glover |
| author_facet | Gianluca Amadei David M. Glover |
| author_sort | Gianluca Amadei |
| collection | DOAJ |
| description | Studies over the past decade have shown how stem cells representing embryonic and extra-embryonic tissues of the mouse can self-assemble in the culture dish to recapitulate an astonishing part of early embryonic development. A systematic analysis has demonstrated how pluripotent embryonic stem cells can be induced to behave like the implanting epiblast; how they can interact with trophectoderm stem cells to form a patterned structure resembling the implanting embryo prior to gastrulation; and how the third stem cell type—extra-embryonic endoderm cells—can be incorporated to generate structures that undergo the cell movements and gene expression patterns of gastrulation. Moreover, such stem cell-derived embryo models can proceed to neurulation and establish progenitors for all parts of the brain and neural tube, somites, beating heart structures and gut tube. They develop within extra-embryonic yolk sacs that initiate haematopoiesis. Here we trace this journey of discovery. |
| first_indexed | 2024-03-13T00:57:39Z |
| format | Article |
| id | doaj.art-fd42485fb1c1499db7e7ca02298a4baa |
| institution | Directory Open Access Journal |
| issn | 2046-2441 |
| language | English |
| last_indexed | 2024-03-13T00:57:39Z |
| publishDate | 2023-01-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Open Biology |
| spelling | doaj.art-fd42485fb1c1499db7e7ca02298a4baa2023-07-06T15:52:04ZengThe Royal SocietyOpen Biology2046-24412023-01-0113110.1098/rsob.220325Behind the developing brains and beating hearts of stem cell-derived embryo modelsGianluca Amadei0David M. Glover1Department of Biology, University of Padua, Padua, ItalyDepartment of Genetics, University of Cambridge, Cambridge, UKStudies over the past decade have shown how stem cells representing embryonic and extra-embryonic tissues of the mouse can self-assemble in the culture dish to recapitulate an astonishing part of early embryonic development. A systematic analysis has demonstrated how pluripotent embryonic stem cells can be induced to behave like the implanting epiblast; how they can interact with trophectoderm stem cells to form a patterned structure resembling the implanting embryo prior to gastrulation; and how the third stem cell type—extra-embryonic endoderm cells—can be incorporated to generate structures that undergo the cell movements and gene expression patterns of gastrulation. Moreover, such stem cell-derived embryo models can proceed to neurulation and establish progenitors for all parts of the brain and neural tube, somites, beating heart structures and gut tube. They develop within extra-embryonic yolk sacs that initiate haematopoiesis. Here we trace this journey of discovery.https://royalsocietypublishing.org/doi/10.1098/rsob.220325stem cellsembryo modelshaematopoiesis |
| spellingShingle | Gianluca Amadei David M. Glover Behind the developing brains and beating hearts of stem cell-derived embryo models Open Biology stem cells embryo models haematopoiesis |
| title | Behind the developing brains and beating hearts of stem cell-derived embryo models |
| title_full | Behind the developing brains and beating hearts of stem cell-derived embryo models |
| title_fullStr | Behind the developing brains and beating hearts of stem cell-derived embryo models |
| title_full_unstemmed | Behind the developing brains and beating hearts of stem cell-derived embryo models |
| title_short | Behind the developing brains and beating hearts of stem cell-derived embryo models |
| title_sort | behind the developing brains and beating hearts of stem cell derived embryo models |
| topic | stem cells embryo models haematopoiesis |
| url | https://royalsocietypublishing.org/doi/10.1098/rsob.220325 |
| work_keys_str_mv | AT gianlucaamadei behindthedevelopingbrainsandbeatingheartsofstemcellderivedembryomodels AT davidmglover behindthedevelopingbrainsandbeatingheartsofstemcellderivedembryomodels |