COVID-19 and pancreatitis: A review of the potential association
Originally thought to be a respiratory pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), has been shown to cause a dizzying array of symptoms, including all major organ systems of the human body. As time elapsed, new st...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Society of Gastrointestinal Intervention
2023-01-01
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| Series: | International Journal of Gastrointestinal Intervention |
| Subjects: | |
| Online Access: | https://www.ijgii.org/journal/view.html?doi=10.18528/ijgii210060 |
| _version_ | 1797938155005935616 |
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| author | Asad Ali Kerawala Bhagwan Das Rabika Fatima Ahda Solangi |
| author_facet | Asad Ali Kerawala Bhagwan Das Rabika Fatima Ahda Solangi |
| author_sort | Asad Ali Kerawala |
| collection | DOAJ |
| description | Originally thought to be a respiratory pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), has been shown to cause a dizzying array of symptoms, including all major organ systems of the human body. As time elapsed, new strains of the virus have emerged, validating concerns about genetic mutation. No single treatment has proven beneficial in treating the consequences, and the world has been left at the mercy of this deadly pathogen. It has been proven that COVID-19 can cause strokes, myocardial infarcts, mesenteric infarcts, acute limb ischemia, and a wide array of other symptomatology. This review aimed to evaluate whether there exists an association between COVID-19 and pancreatitis. Forty publications (34 case reports and 4 case series) were included in the review. In total, 44 cases of acute pancreatitis (38 cases of acute edematous pancreatitis and 6 cases of necrotizing pancreatitis) in COVID-19 patients without any predisposing factors have been published since January 2020. Fortunately, only 4 (9.1%) of these patients were reported to have died. Although the exact mechanism by which COVID-19 causes pancreatitis is still unclear, studies so far have reported it as a multifactorial phenomenon. COVID-19 associated pancreatic injury is thought to involve direct cellular damage via local replication of SARS-CoV-2 within pancreatic cells, as they express angiotensin-converting enzyme 2 receptors even more strongly than lung cells. Our review concludes that acute pancreatitis should be kept in the differential list of all COVID-19 patients with gastrointestinal manifestations, especially in patients with acute abdomen. |
| first_indexed | 2024-04-10T18:55:18Z |
| format | Article |
| id | doaj.art-fd435a8956a746c6a9ab141ef850a024 |
| institution | Directory Open Access Journal |
| issn | 2636-0004 |
| language | English |
| last_indexed | 2024-04-10T18:55:18Z |
| publishDate | 2023-01-01 |
| publisher | Society of Gastrointestinal Intervention |
| record_format | Article |
| series | International Journal of Gastrointestinal Intervention |
| spelling | doaj.art-fd435a8956a746c6a9ab141ef850a0242023-02-01T03:21:41ZengSociety of Gastrointestinal InterventionInternational Journal of Gastrointestinal Intervention2636-00042023-01-01121222810.18528/ijgii210060ijgii210060COVID-19 and pancreatitis: A review of the potential associationAsad Ali Kerawala0Bhagwan Das1Rabika Fatima2Ahda Solangi3Department of Surgery, Cancer Foundation Hospital, Karachi, PakistanDepartment of Endocrinology, Cancer Foundation Hospital, Karachi, PakistanDepartment of Surgery, Dow University of Health Sciences, Karachi, PakistanDepartment of Medicine, New York Medical College, Valhalla, NY, USAOriginally thought to be a respiratory pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), has been shown to cause a dizzying array of symptoms, including all major organ systems of the human body. As time elapsed, new strains of the virus have emerged, validating concerns about genetic mutation. No single treatment has proven beneficial in treating the consequences, and the world has been left at the mercy of this deadly pathogen. It has been proven that COVID-19 can cause strokes, myocardial infarcts, mesenteric infarcts, acute limb ischemia, and a wide array of other symptomatology. This review aimed to evaluate whether there exists an association between COVID-19 and pancreatitis. Forty publications (34 case reports and 4 case series) were included in the review. In total, 44 cases of acute pancreatitis (38 cases of acute edematous pancreatitis and 6 cases of necrotizing pancreatitis) in COVID-19 patients without any predisposing factors have been published since January 2020. Fortunately, only 4 (9.1%) of these patients were reported to have died. Although the exact mechanism by which COVID-19 causes pancreatitis is still unclear, studies so far have reported it as a multifactorial phenomenon. COVID-19 associated pancreatic injury is thought to involve direct cellular damage via local replication of SARS-CoV-2 within pancreatic cells, as they express angiotensin-converting enzyme 2 receptors even more strongly than lung cells. Our review concludes that acute pancreatitis should be kept in the differential list of all COVID-19 patients with gastrointestinal manifestations, especially in patients with acute abdomen.https://www.ijgii.org/journal/view.html?doi=10.18528/ijgii210060covid-19; necrotizing pancreatitis; pancreatitis; sars-cov-2 |
| spellingShingle | Asad Ali Kerawala Bhagwan Das Rabika Fatima Ahda Solangi COVID-19 and pancreatitis: A review of the potential association International Journal of Gastrointestinal Intervention covid-19; necrotizing pancreatitis; pancreatitis; sars-cov-2 |
| title | COVID-19 and pancreatitis: A review of the potential association |
| title_full | COVID-19 and pancreatitis: A review of the potential association |
| title_fullStr | COVID-19 and pancreatitis: A review of the potential association |
| title_full_unstemmed | COVID-19 and pancreatitis: A review of the potential association |
| title_short | COVID-19 and pancreatitis: A review of the potential association |
| title_sort | covid 19 and pancreatitis a review of the potential association |
| topic | covid-19; necrotizing pancreatitis; pancreatitis; sars-cov-2 |
| url | https://www.ijgii.org/journal/view.html?doi=10.18528/ijgii210060 |
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