Suppressing nonsense—a surprising function for 5‐azacytidine
In this issue of EMBO Molecular Medicine, Bhuvanagiri et al report on a chemical means to convert molecular junk into gold. They identify a chemical inhibitor of a quality control pathway that is best known for its ability to clear cells of rubbish, but that in certain cases can be detrimental becau...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer Nature
2014-12-01
|
| Series: | EMBO Molecular Medicine |
| Online Access: | https://doi.org/10.15252/emmm.201404569 |
| _version_ | 1797225458063900672 |
|---|---|
| author | Ada Shao Miles F Wilkinson |
| author_facet | Ada Shao Miles F Wilkinson |
| author_sort | Ada Shao |
| collection | DOAJ |
| description | In this issue of EMBO Molecular Medicine, Bhuvanagiri et al report on a chemical means to convert molecular junk into gold. They identify a chemical inhibitor of a quality control pathway that is best known for its ability to clear cells of rubbish, but that in certain cases can be detrimental because it eliminates “useful” garbage. The chemical inhibitor identified by Bhuvanagiri et al perturbs Nonsense‐Mediated RNA Decay (NMD), a RNA surveillance pathway that targets mRNAs harboring premature termination codons (PTCs) for degradation (Kervestin & Jacobson, ). |
| first_indexed | 2024-03-13T03:11:28Z |
| format | Article |
| id | doaj.art-fd448c4d8a394352bce19d3dc1fb2d70 |
| institution | Directory Open Access Journal |
| issn | 1757-4676 1757-4684 |
| language | English |
| last_indexed | 2024-04-24T14:09:20Z |
| publishDate | 2014-12-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj.art-fd448c4d8a394352bce19d3dc1fb2d702024-04-03T09:41:46ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842014-12-016121518152010.15252/emmm.201404569Suppressing nonsense—a surprising function for 5‐azacytidineAda Shao0Miles F Wilkinson1Department of Reproductive Medicine University of California San Diego CA USADepartment of Reproductive Medicine University of California San Diego CA USAIn this issue of EMBO Molecular Medicine, Bhuvanagiri et al report on a chemical means to convert molecular junk into gold. They identify a chemical inhibitor of a quality control pathway that is best known for its ability to clear cells of rubbish, but that in certain cases can be detrimental because it eliminates “useful” garbage. The chemical inhibitor identified by Bhuvanagiri et al perturbs Nonsense‐Mediated RNA Decay (NMD), a RNA surveillance pathway that targets mRNAs harboring premature termination codons (PTCs) for degradation (Kervestin & Jacobson, ).https://doi.org/10.15252/emmm.201404569 |
| spellingShingle | Ada Shao Miles F Wilkinson Suppressing nonsense—a surprising function for 5‐azacytidine EMBO Molecular Medicine |
| title | Suppressing nonsense—a surprising function for 5‐azacytidine |
| title_full | Suppressing nonsense—a surprising function for 5‐azacytidine |
| title_fullStr | Suppressing nonsense—a surprising function for 5‐azacytidine |
| title_full_unstemmed | Suppressing nonsense—a surprising function for 5‐azacytidine |
| title_short | Suppressing nonsense—a surprising function for 5‐azacytidine |
| title_sort | suppressing nonsense a surprising function for 5 azacytidine |
| url | https://doi.org/10.15252/emmm.201404569 |
| work_keys_str_mv | AT adashao suppressingnonsenseasurprisingfunctionfor5azacytidine AT milesfwilkinson suppressingnonsenseasurprisingfunctionfor5azacytidine |