Risk factors and mortality in patients with pneumonia and elevated troponin levels
Abstract Pneumonia in hospitalized patients is associated with myocardial injury. In this study, we evaluated risk factors for myocardial injury in hospitalized patients with pneumonia and its prognostic value. We retrieved all patients who were hospitalized in internal medicine departments in a ter...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-78287-1 |
| _version_ | 1818998784137363456 |
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| author | Orly Efros Shelly Soffer Avshalom Leibowitz Alexander Fardman Robert Klempfner Eshcar Meisel Ehud Grossman |
| author_facet | Orly Efros Shelly Soffer Avshalom Leibowitz Alexander Fardman Robert Klempfner Eshcar Meisel Ehud Grossman |
| author_sort | Orly Efros |
| collection | DOAJ |
| description | Abstract Pneumonia in hospitalized patients is associated with myocardial injury. In this study, we evaluated risk factors for myocardial injury in hospitalized patients with pneumonia and its prognostic value. We retrieved all patients who were hospitalized in internal medicine departments in a tertiary medical center between 2008 and 2019 with a diagnosis of pneumonia. From 2008 to 2019 a total of 20,683 adult patients were hospitalized in internal medicine wards in the Sheba Medical Center with a diagnosis of pneumonia, 8195 were tested for troponin levels, and 3207 had elevated levels. Risk factors for elevated troponin levels were age, prior diagnosis of ischemic heart disease, and elevated creatinine level upon admission. The in-hospital mortality and 1-year mortality rate were higher among patients who had elevated troponin levels when using a propensity score-based matched analysis. In conclusion, in hospitalized patients with pneumonia elevated troponin levels have a major impact on prognosis. Hence, troponin levels may be used as another tool of risk stratification for patients hospitalized with pneumonia. |
| first_indexed | 2024-12-20T22:07:01Z |
| format | Article |
| id | doaj.art-fd44c289252c45efac6395a7cd8a973a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T22:07:01Z |
| publishDate | 2020-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-fd44c289252c45efac6395a7cd8a973a2022-12-21T19:25:15ZengNature PortfolioScientific Reports2045-23222020-12-011011710.1038/s41598-020-78287-1Risk factors and mortality in patients with pneumonia and elevated troponin levelsOrly Efros0Shelly Soffer1Avshalom Leibowitz2Alexander Fardman3Robert Klempfner4Eshcar Meisel5Ehud Grossman6Internal Medicine D, Sheba Medical CenterSackler Faculty of Medicine, Tel-Aviv UniversityInternal Medicine D, Sheba Medical CenterSackler Faculty of Medicine, Tel-Aviv UniversitySackler Faculty of Medicine, Tel-Aviv UniversityInternal Medicine D, Sheba Medical CenterSackler Faculty of Medicine, Tel-Aviv UniversityAbstract Pneumonia in hospitalized patients is associated with myocardial injury. In this study, we evaluated risk factors for myocardial injury in hospitalized patients with pneumonia and its prognostic value. We retrieved all patients who were hospitalized in internal medicine departments in a tertiary medical center between 2008 and 2019 with a diagnosis of pneumonia. From 2008 to 2019 a total of 20,683 adult patients were hospitalized in internal medicine wards in the Sheba Medical Center with a diagnosis of pneumonia, 8195 were tested for troponin levels, and 3207 had elevated levels. Risk factors for elevated troponin levels were age, prior diagnosis of ischemic heart disease, and elevated creatinine level upon admission. The in-hospital mortality and 1-year mortality rate were higher among patients who had elevated troponin levels when using a propensity score-based matched analysis. In conclusion, in hospitalized patients with pneumonia elevated troponin levels have a major impact on prognosis. Hence, troponin levels may be used as another tool of risk stratification for patients hospitalized with pneumonia.https://doi.org/10.1038/s41598-020-78287-1 |
| spellingShingle | Orly Efros Shelly Soffer Avshalom Leibowitz Alexander Fardman Robert Klempfner Eshcar Meisel Ehud Grossman Risk factors and mortality in patients with pneumonia and elevated troponin levels Scientific Reports |
| title | Risk factors and mortality in patients with pneumonia and elevated troponin levels |
| title_full | Risk factors and mortality in patients with pneumonia and elevated troponin levels |
| title_fullStr | Risk factors and mortality in patients with pneumonia and elevated troponin levels |
| title_full_unstemmed | Risk factors and mortality in patients with pneumonia and elevated troponin levels |
| title_short | Risk factors and mortality in patients with pneumonia and elevated troponin levels |
| title_sort | risk factors and mortality in patients with pneumonia and elevated troponin levels |
| url | https://doi.org/10.1038/s41598-020-78287-1 |
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