Heme-Based Gas Sensors in Nature and Their Chemical and Biotechnological Applications
Sensing is an essential feature of life, where many systems have been developed. Diatomic molecules such as O<sub>2</sub>, NO and CO exhibit an important role in life, which requires specialized sensors. Among the sensors discovered, heme-based gas sensors compose the largest group with...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | BioChem |
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| Online Access: | https://www.mdpi.com/2673-6411/2/1/4 |
| _version_ | 1797472873744433152 |
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| author | Ana Claudia Silva Gondim Wellinson Gadelha Guimarães Eduardo Henrique Silva Sousa |
| author_facet | Ana Claudia Silva Gondim Wellinson Gadelha Guimarães Eduardo Henrique Silva Sousa |
| author_sort | Ana Claudia Silva Gondim |
| collection | DOAJ |
| description | Sensing is an essential feature of life, where many systems have been developed. Diatomic molecules such as O<sub>2</sub>, NO and CO exhibit an important role in life, which requires specialized sensors. Among the sensors discovered, heme-based gas sensors compose the largest group with at least eight different families. This large variety of proteins also exhibits many distinct ways of sensing diatomic molecules and promote a response for biological adaptation. Here, we briefly describe a story of two impressive systems of heme-based oxygen sensors, FixL from <i>Rhizobium</i> and DevS(DosS)/DosT from <i>Mycobacterium tuberculosis</i>. Beyond this, we also examined many applications that have emerged. These heme-based gas sensors have been manipulated to function as chemical and biochemical analytical systems to detect small molecules (O<sub>2</sub>, CO, NO, CN<sup>−</sup>), fluorophores for imaging and bioanalysis, regulation of processes in synthetic biology and preparation of biocatalysts among others. These exciting features show the robustness of this field and multiple opportunities ahead besides the advances in the fundamental understanding of their molecular functioning. |
| first_indexed | 2024-03-09T20:07:20Z |
| format | Article |
| id | doaj.art-fd455d6cab2949ed9541e3664d013efd |
| institution | Directory Open Access Journal |
| issn | 2673-6411 |
| language | English |
| last_indexed | 2024-03-09T20:07:20Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | BioChem |
| spelling | doaj.art-fd455d6cab2949ed9541e3664d013efd2023-11-24T00:29:56ZengMDPI AGBioChem2673-64112022-02-0121436310.3390/biochem2010004Heme-Based Gas Sensors in Nature and Their Chemical and Biotechnological ApplicationsAna Claudia Silva Gondim0Wellinson Gadelha Guimarães1Eduardo Henrique Silva Sousa2Bioinorganic Group, Department of Organic and Inorganic Chemistry, Federal University of Ceara, Fortaleza 60440-900, BrazilBioinorganic Group, Department of Organic and Inorganic Chemistry, Federal University of Ceara, Fortaleza 60440-900, BrazilBioinorganic Group, Department of Organic and Inorganic Chemistry, Federal University of Ceara, Fortaleza 60440-900, BrazilSensing is an essential feature of life, where many systems have been developed. Diatomic molecules such as O<sub>2</sub>, NO and CO exhibit an important role in life, which requires specialized sensors. Among the sensors discovered, heme-based gas sensors compose the largest group with at least eight different families. This large variety of proteins also exhibits many distinct ways of sensing diatomic molecules and promote a response for biological adaptation. Here, we briefly describe a story of two impressive systems of heme-based oxygen sensors, FixL from <i>Rhizobium</i> and DevS(DosS)/DosT from <i>Mycobacterium tuberculosis</i>. Beyond this, we also examined many applications that have emerged. These heme-based gas sensors have been manipulated to function as chemical and biochemical analytical systems to detect small molecules (O<sub>2</sub>, CO, NO, CN<sup>−</sup>), fluorophores for imaging and bioanalysis, regulation of processes in synthetic biology and preparation of biocatalysts among others. These exciting features show the robustness of this field and multiple opportunities ahead besides the advances in the fundamental understanding of their molecular functioning.https://www.mdpi.com/2673-6411/2/1/4heme-based gas sensorsDevS/DosT/DevRFixLbioanalytical toolbiotechnological applications |
| spellingShingle | Ana Claudia Silva Gondim Wellinson Gadelha Guimarães Eduardo Henrique Silva Sousa Heme-Based Gas Sensors in Nature and Their Chemical and Biotechnological Applications BioChem heme-based gas sensors DevS/DosT/DevR FixL bioanalytical tool biotechnological applications |
| title | Heme-Based Gas Sensors in Nature and Their Chemical and Biotechnological Applications |
| title_full | Heme-Based Gas Sensors in Nature and Their Chemical and Biotechnological Applications |
| title_fullStr | Heme-Based Gas Sensors in Nature and Their Chemical and Biotechnological Applications |
| title_full_unstemmed | Heme-Based Gas Sensors in Nature and Their Chemical and Biotechnological Applications |
| title_short | Heme-Based Gas Sensors in Nature and Their Chemical and Biotechnological Applications |
| title_sort | heme based gas sensors in nature and their chemical and biotechnological applications |
| topic | heme-based gas sensors DevS/DosT/DevR FixL bioanalytical tool biotechnological applications |
| url | https://www.mdpi.com/2673-6411/2/1/4 |
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