Anti-inflammatory and antioxidant efficacy of lavender oil in experimentally induced thrombosis
Abstract Background Lavender oil (LO) possesses anti-inflammatory, antioxidant, antifungal, antibacterial, sedative, cardio-protective, and antinociceptive properties. Thrombosis and inflammation are interplayed processes that interact and influence one another. Our research compared three routes of...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-08-01
|
| Series: | Thrombosis Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12959-023-00516-0 |
| _version_ | 1827633424489250816 |
|---|---|
| author | Valeriu Mihai But Adriana Elena Bulboacă Vasile Rus Tamás Ilyés Mădălina Luciana Gherman Sorana D. Bolboacă |
| author_facet | Valeriu Mihai But Adriana Elena Bulboacă Vasile Rus Tamás Ilyés Mădălina Luciana Gherman Sorana D. Bolboacă |
| author_sort | Valeriu Mihai But |
| collection | DOAJ |
| description | Abstract Background Lavender oil (LO) possesses anti-inflammatory, antioxidant, antifungal, antibacterial, sedative, cardio-protective, and antinociceptive properties. Thrombosis and inflammation are interplayed processes that interact and influence one another. Our research compared three routes of administration to assess the efficacy of pretreatment with LO on carrageenan-induced thrombosis in rat tail. Materials and methods Wistar-Bratislava white rats were randomly divided into five groups of ten rats each and pretreated 3 consecutive days prior the inducement of thrombosis to with one dose of LO (150 mg/kg body weight (b.w.)): per os by gavage (TLOPO group), intraperitoneal (TIPLO group) and subcutaneous (TSCLO group). We also have a control (C, received saline solution 0.9% and DMSO (vehicle) 1 ml intraperitoneal (i.p.)) group and a group with thrombosis (T group, received saline solution 0.9% plus vehicle 1 ml i.p.). Histopathological examinations were conducted together with measurements of the circulating levels of three oxidative stress markers, antioxidant effect (TAC and THIOL), and three proinflammatory cytokines (TNF- α, RANTES, and MCP-1). Results When administered intraperitoneally, lavender oil has the best efficacy on circulating levels of oxidative stress parameters (MDA, NOx, TOS), one oxidative stress marker (THIOL), and all studied proinflammatory cytokines (p-values < 0.02). Moreover, TIPLO displayed the closest values for bleeding and clotting time to the C group, as well as the lowest length of the thrombus than the T, TPOLO, and TSCLO groups (p-values < 0.001). The TIPLO group has histological appearance comparable to the C group, with the exception of the presence of oedema. Conclusions Lavender oil pretreatment with intraperitoneal administration as three days, one-dose per day, showed anti-inflammatory and antioxidant efficacy in experimentally induced thrombosis. |
| first_indexed | 2024-03-09T14:59:37Z |
| format | Article |
| id | doaj.art-fd455daa5971469fa34cdc9754841f8c |
| institution | Directory Open Access Journal |
| issn | 1477-9560 |
| language | English |
| last_indexed | 2024-03-09T14:59:37Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Thrombosis Journal |
| spelling | doaj.art-fd455daa5971469fa34cdc9754841f8c2023-11-26T14:00:24ZengBMCThrombosis Journal1477-95602023-08-0121111310.1186/s12959-023-00516-0Anti-inflammatory and antioxidant efficacy of lavender oil in experimentally induced thrombosisValeriu Mihai But0Adriana Elena Bulboacă1Vasile Rus2Tamás Ilyés3Mădălina Luciana Gherman4Sorana D. Bolboacă5Department of Medical Informatics and Biostatistics, “Iuliu Haţieganu” University of Medicine and PharmacyDepartment of Pathophysiology, “Iuliu Haţieganu” University of Medicine and PharmacyDepartment of Cell Biology, Histology and Embryology, University of Agricultural Sciences and Veterinary MedicineDepartment of Medical Biochemistry, “Iuliu Haţieganu” University of Medicine and PharmacyExperimental Center, “Iuliu Haţieganu” University of Medicine and PharmacyDepartment of Medical Informatics and Biostatistics, “Iuliu Haţieganu” University of Medicine and PharmacyAbstract Background Lavender oil (LO) possesses anti-inflammatory, antioxidant, antifungal, antibacterial, sedative, cardio-protective, and antinociceptive properties. Thrombosis and inflammation are interplayed processes that interact and influence one another. Our research compared three routes of administration to assess the efficacy of pretreatment with LO on carrageenan-induced thrombosis in rat tail. Materials and methods Wistar-Bratislava white rats were randomly divided into five groups of ten rats each and pretreated 3 consecutive days prior the inducement of thrombosis to with one dose of LO (150 mg/kg body weight (b.w.)): per os by gavage (TLOPO group), intraperitoneal (TIPLO group) and subcutaneous (TSCLO group). We also have a control (C, received saline solution 0.9% and DMSO (vehicle) 1 ml intraperitoneal (i.p.)) group and a group with thrombosis (T group, received saline solution 0.9% plus vehicle 1 ml i.p.). Histopathological examinations were conducted together with measurements of the circulating levels of three oxidative stress markers, antioxidant effect (TAC and THIOL), and three proinflammatory cytokines (TNF- α, RANTES, and MCP-1). Results When administered intraperitoneally, lavender oil has the best efficacy on circulating levels of oxidative stress parameters (MDA, NOx, TOS), one oxidative stress marker (THIOL), and all studied proinflammatory cytokines (p-values < 0.02). Moreover, TIPLO displayed the closest values for bleeding and clotting time to the C group, as well as the lowest length of the thrombus than the T, TPOLO, and TSCLO groups (p-values < 0.001). The TIPLO group has histological appearance comparable to the C group, with the exception of the presence of oedema. Conclusions Lavender oil pretreatment with intraperitoneal administration as three days, one-dose per day, showed anti-inflammatory and antioxidant efficacy in experimentally induced thrombosis.https://doi.org/10.1186/s12959-023-00516-0Lavender oilThrombosisAnti-inflammatory agentsOxidative stress |
| spellingShingle | Valeriu Mihai But Adriana Elena Bulboacă Vasile Rus Tamás Ilyés Mădălina Luciana Gherman Sorana D. Bolboacă Anti-inflammatory and antioxidant efficacy of lavender oil in experimentally induced thrombosis Thrombosis Journal Lavender oil Thrombosis Anti-inflammatory agents Oxidative stress |
| title | Anti-inflammatory and antioxidant efficacy of lavender oil in experimentally induced thrombosis |
| title_full | Anti-inflammatory and antioxidant efficacy of lavender oil in experimentally induced thrombosis |
| title_fullStr | Anti-inflammatory and antioxidant efficacy of lavender oil in experimentally induced thrombosis |
| title_full_unstemmed | Anti-inflammatory and antioxidant efficacy of lavender oil in experimentally induced thrombosis |
| title_short | Anti-inflammatory and antioxidant efficacy of lavender oil in experimentally induced thrombosis |
| title_sort | anti inflammatory and antioxidant efficacy of lavender oil in experimentally induced thrombosis |
| topic | Lavender oil Thrombosis Anti-inflammatory agents Oxidative stress |
| url | https://doi.org/10.1186/s12959-023-00516-0 |
| work_keys_str_mv | AT valeriumihaibut antiinflammatoryandantioxidantefficacyoflavenderoilinexperimentallyinducedthrombosis AT adrianaelenabulboaca antiinflammatoryandantioxidantefficacyoflavenderoilinexperimentallyinducedthrombosis AT vasilerus antiinflammatoryandantioxidantefficacyoflavenderoilinexperimentallyinducedthrombosis AT tamasilyes antiinflammatoryandantioxidantefficacyoflavenderoilinexperimentallyinducedthrombosis AT madalinalucianagherman antiinflammatoryandantioxidantefficacyoflavenderoilinexperimentallyinducedthrombosis AT soranadbolboaca antiinflammatoryandantioxidantefficacyoflavenderoilinexperimentallyinducedthrombosis |