New Hyaluronic Acid Preparations in the Treatment of Children with Dry Eye Syndrome

The aim of the study was to evaluate the effectiveness of the preparations Optinol® Express Moisture (0.21 %) and Optinol® Deep Moisture (0.4 %) in the treatment of children with dry eye syndrome (DES) and to determine the indications for prescribing these drugs for various etiologies and clinical c...

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Main Authors: V. V. Brzheskiy, I. N. Gorbachevskaya, S. Y. Golubev
Format: Article
Language:Russian
Published: Ophthalmology Publishing Group 2021-04-01
Series:Oftalʹmologiâ
Subjects:
Online Access:https://www.ophthalmojournal.com/opht/article/view/1446
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author V. V. Brzheskiy
I. N. Gorbachevskaya
S. Y. Golubev
author_facet V. V. Brzheskiy
I. N. Gorbachevskaya
S. Y. Golubev
author_sort V. V. Brzheskiy
collection DOAJ
description The aim of the study was to evaluate the effectiveness of the preparations Optinol® Express Moisture (0.21 %) and Optinol® Deep Moisture (0.4 %) in the treatment of children with dry eye syndrome (DES) and to determine the indications for prescribing these drugs for various etiologies and clinical course of the disease.Patients and methods. The study involved 56 children aged 4–17 years with DES, which were divided into 3 groups, depending on its pathogenetic type. The first consisted of 24 children with DES, which developed on the basis of chronic blepharitis, the second — 12 children with neuroparalytic keratitis, and the third — 18 children with chronic uveitis, in whom DES was caused by prolonged instillations of eye drops with benzalkonium chloride. Each group was divided into 2 more equal subgroups, the first of which was prescribed the drug Optinol® Express Moisture, and the second — Optinol® Deep Moisture with a frequency of 4 times a day.Results. In all children, from the very first days of instillation of the studied drugs, a decrease in the severity of subjective signs of DES (OSDI) was noted, as well as a gradual decrease in the degree of xerotic changes in the ocular surface (severity of its staining with vital dyes) and an increase in the stability of the tear film (M.Norn). At the same time, the positive dynamics of the controlled parameters increased with the continuation of therapy, reaching a maximum by the 30th day of treatment. Moreover, the effectiveness of therapy depended on the severity of xerosis of the ocular surface: it was maximal in children with mild, and minimal in children with an extremely severe form of xerosis (with neuroparalytic keratitis). Moreover, the drug Optinol® Express Moisture was more effective in the treatment of children with mild and extremely severe forms of DES, and Optinol® Deep Moisture — with moderate and severe xerosis.Conclusion. The preparations Optinol® Express Moisture and Optinol® Deep Moisturization are effective in the treatment of children with DES, which has developed on the basis of pathology of the ocular surface of neurotrophic and artifact genesis, as well as increased volatility of the precorneal tear film against the background of chronic blepharitis.
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spelling doaj.art-fd45be134e2649c988e5bad4a630c30e2023-03-13T09:08:41ZrusOphthalmology Publishing GroupOftalʹmologiâ1816-50952500-08452021-04-0118112913510.18008/1816-5095-2021-1-129-135736New Hyaluronic Acid Preparations in the Treatment of Children with Dry Eye SyndromeV. V. Brzheskiy0I. N. Gorbachevskaya1S. Y. Golubev2ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Министерства здравоохранения Российской ФедерацииФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Министерства здравоохранения Российской ФедерацииФГБУН «Государственный научный центр Российской Федерации — Институт медико-биологических проблем Российской академии наук»The aim of the study was to evaluate the effectiveness of the preparations Optinol® Express Moisture (0.21 %) and Optinol® Deep Moisture (0.4 %) in the treatment of children with dry eye syndrome (DES) and to determine the indications for prescribing these drugs for various etiologies and clinical course of the disease.Patients and methods. The study involved 56 children aged 4–17 years with DES, which were divided into 3 groups, depending on its pathogenetic type. The first consisted of 24 children with DES, which developed on the basis of chronic blepharitis, the second — 12 children with neuroparalytic keratitis, and the third — 18 children with chronic uveitis, in whom DES was caused by prolonged instillations of eye drops with benzalkonium chloride. Each group was divided into 2 more equal subgroups, the first of which was prescribed the drug Optinol® Express Moisture, and the second — Optinol® Deep Moisture with a frequency of 4 times a day.Results. In all children, from the very first days of instillation of the studied drugs, a decrease in the severity of subjective signs of DES (OSDI) was noted, as well as a gradual decrease in the degree of xerotic changes in the ocular surface (severity of its staining with vital dyes) and an increase in the stability of the tear film (M.Norn). At the same time, the positive dynamics of the controlled parameters increased with the continuation of therapy, reaching a maximum by the 30th day of treatment. Moreover, the effectiveness of therapy depended on the severity of xerosis of the ocular surface: it was maximal in children with mild, and minimal in children with an extremely severe form of xerosis (with neuroparalytic keratitis). Moreover, the drug Optinol® Express Moisture was more effective in the treatment of children with mild and extremely severe forms of DES, and Optinol® Deep Moisture — with moderate and severe xerosis.Conclusion. The preparations Optinol® Express Moisture and Optinol® Deep Moisturization are effective in the treatment of children with DES, which has developed on the basis of pathology of the ocular surface of neurotrophic and artifact genesis, as well as increased volatility of the precorneal tear film against the background of chronic blepharitis.https://www.ophthalmojournal.com/opht/article/view/1446синдром сухого глаза у детейлечениепрепараты искусственной слезыоптинол
spellingShingle V. V. Brzheskiy
I. N. Gorbachevskaya
S. Y. Golubev
New Hyaluronic Acid Preparations in the Treatment of Children with Dry Eye Syndrome
Oftalʹmologiâ
синдром сухого глаза у детей
лечение
препараты искусственной слезы
оптинол
title New Hyaluronic Acid Preparations in the Treatment of Children with Dry Eye Syndrome
title_full New Hyaluronic Acid Preparations in the Treatment of Children with Dry Eye Syndrome
title_fullStr New Hyaluronic Acid Preparations in the Treatment of Children with Dry Eye Syndrome
title_full_unstemmed New Hyaluronic Acid Preparations in the Treatment of Children with Dry Eye Syndrome
title_short New Hyaluronic Acid Preparations in the Treatment of Children with Dry Eye Syndrome
title_sort new hyaluronic acid preparations in the treatment of children with dry eye syndrome
topic синдром сухого глаза у детей
лечение
препараты искусственной слезы
оптинол
url https://www.ophthalmojournal.com/opht/article/view/1446
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AT ingorbachevskaya newhyaluronicacidpreparationsinthetreatmentofchildrenwithdryeyesyndrome
AT sygolubev newhyaluronicacidpreparationsinthetreatmentofchildrenwithdryeyesyndrome