Temporary consumption of western diet trains the immune system to reduce future gut inflammation
Summary: Urbanization drives the popularity of western diet (WD), which increased burden in metabolic diseases but also in inflammatory diseases. Here, we show continuous WD disrupted the gut barrier, initiating low-grade inflammation and enhancing the colitis response. Nevertheless, transient WD co...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-06-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223009926 |
| _version_ | 1827934693297750016 |
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| author | Dongwen Wu Xiaotong Wang Xiang Yang Lei Gu Mandy J. McGeachy Xiaowei Liu |
| author_facet | Dongwen Wu Xiaotong Wang Xiang Yang Lei Gu Mandy J. McGeachy Xiaowei Liu |
| author_sort | Dongwen Wu |
| collection | DOAJ |
| description | Summary: Urbanization drives the popularity of western diet (WD), which increased burden in metabolic diseases but also in inflammatory diseases. Here, we show continuous WD disrupted the gut barrier, initiating low-grade inflammation and enhancing the colitis response. Nevertheless, transient WD consumption followed by ad libitum normal diet enhanced mucin production and tight junction protein expression in recovered mice. Furthermore, transient WD consumption surprisingly reduced the subsequent inflammatory response in DSS colitis and Citrobacter rodentium-infection induced colitis. The protective effect of WD training was not sex-dependent, and co-housing experiments suggested microbiota changes were not responsible. We identified important roles for cholesterol biosynthesis pathway and macrophages, pointing to innate myeloid training. Together, these data suggest detrimental effects of WD consumption can be reversed on return to a healthier diet. Furthermore, transient WD consumption leads to beneficial immune training, suggesting an evolutionary mechanism to benefit from feasting when abundant food is available. |
| first_indexed | 2024-03-13T07:43:23Z |
| format | Article |
| id | doaj.art-fd463c601f134957ac4414fdadfc4374 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-13T07:43:23Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-fd463c601f134957ac4414fdadfc43742023-06-03T04:22:32ZengElsevieriScience2589-00422023-06-01266106915Temporary consumption of western diet trains the immune system to reduce future gut inflammationDongwen Wu0Xiaotong Wang1Xiang Yang2Lei Gu3Mandy J. McGeachy4Xiaowei Liu5Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, ChinaDepartment of Gastroenterology, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, ChinaChangsha Aier Eye Hospital, Changsha, Hunan, ChinaDepartment of Gastroenterology, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, ChinaDepartment of Microbiology & Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USADepartment of Gastroenterology, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China; Corresponding authorSummary: Urbanization drives the popularity of western diet (WD), which increased burden in metabolic diseases but also in inflammatory diseases. Here, we show continuous WD disrupted the gut barrier, initiating low-grade inflammation and enhancing the colitis response. Nevertheless, transient WD consumption followed by ad libitum normal diet enhanced mucin production and tight junction protein expression in recovered mice. Furthermore, transient WD consumption surprisingly reduced the subsequent inflammatory response in DSS colitis and Citrobacter rodentium-infection induced colitis. The protective effect of WD training was not sex-dependent, and co-housing experiments suggested microbiota changes were not responsible. We identified important roles for cholesterol biosynthesis pathway and macrophages, pointing to innate myeloid training. Together, these data suggest detrimental effects of WD consumption can be reversed on return to a healthier diet. Furthermore, transient WD consumption leads to beneficial immune training, suggesting an evolutionary mechanism to benefit from feasting when abundant food is available.http://www.sciencedirect.com/science/article/pii/S2589004223009926ImmunologyImmune systemImmune response |
| spellingShingle | Dongwen Wu Xiaotong Wang Xiang Yang Lei Gu Mandy J. McGeachy Xiaowei Liu Temporary consumption of western diet trains the immune system to reduce future gut inflammation iScience Immunology Immune system Immune response |
| title | Temporary consumption of western diet trains the immune system to reduce future gut inflammation |
| title_full | Temporary consumption of western diet trains the immune system to reduce future gut inflammation |
| title_fullStr | Temporary consumption of western diet trains the immune system to reduce future gut inflammation |
| title_full_unstemmed | Temporary consumption of western diet trains the immune system to reduce future gut inflammation |
| title_short | Temporary consumption of western diet trains the immune system to reduce future gut inflammation |
| title_sort | temporary consumption of western diet trains the immune system to reduce future gut inflammation |
| topic | Immunology Immune system Immune response |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223009926 |
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