Existing problems and new advice on stage criteria of natural history for chronic hepatitis B
Abstract The natural stages of chronic hepatitis B can be divided into four stages according to changes in virology, biochemistry, and pathology. However, there have been significant differences in the recommended stage criteria in the several major guidelines for chronic hepatitis B, especially reg...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-024-10408-x |
| _version_ | 1826901291568201728 |
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| author | Tongjing Xing |
| author_facet | Tongjing Xing |
| author_sort | Tongjing Xing |
| collection | DOAJ |
| description | Abstract The natural stages of chronic hepatitis B can be divided into four stages according to changes in virology, biochemistry, and pathology. However, there have been significant differences in the recommended stage criteria in the several major guidelines for chronic hepatitis B, especially regarding the immune tolerance phase. Inconsistent standards of indicators for different stages resulted in some problems, such as incorrect stage, uncertain stages and poor comparation of related studies. We propose suggestions for revisions to the stage criteria for CHB based on recent researches, including three stages: immune tolerance stage, immune clearance stage, and immune control stage. These revision suggestions rationalize some of the existing problems with the stage criteria for CHB and can significantly reduce the number of patients in the “uncertain stage” or “gray zone,” which is particularly valuable in guiding clinical practice. However, further clinical studies with large samples are needed to confirm these suggestions. |
| first_indexed | 2025-02-17T07:21:23Z |
| format | Article |
| id | doaj.art-fd46dcb5a2114e91b760b7b55d7875ef |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2025-02-17T07:21:23Z |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-fd46dcb5a2114e91b760b7b55d7875ef2025-01-05T12:09:39ZengBMCBMC Infectious Diseases1471-23342025-01-012511810.1186/s12879-024-10408-xExisting problems and new advice on stage criteria of natural history for chronic hepatitis BTongjing Xing0Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical UniversityAbstract The natural stages of chronic hepatitis B can be divided into four stages according to changes in virology, biochemistry, and pathology. However, there have been significant differences in the recommended stage criteria in the several major guidelines for chronic hepatitis B, especially regarding the immune tolerance phase. Inconsistent standards of indicators for different stages resulted in some problems, such as incorrect stage, uncertain stages and poor comparation of related studies. We propose suggestions for revisions to the stage criteria for CHB based on recent researches, including three stages: immune tolerance stage, immune clearance stage, and immune control stage. These revision suggestions rationalize some of the existing problems with the stage criteria for CHB and can significantly reduce the number of patients in the “uncertain stage” or “gray zone,” which is particularly valuable in guiding clinical practice. However, further clinical studies with large samples are needed to confirm these suggestions.https://doi.org/10.1186/s12879-024-10408-xChronic HBV infectionNatural historySstage criteriaNew suggestions |
| spellingShingle | Tongjing Xing Existing problems and new advice on stage criteria of natural history for chronic hepatitis B BMC Infectious Diseases Chronic HBV infection Natural history Sstage criteria New suggestions |
| title | Existing problems and new advice on stage criteria of natural history for chronic hepatitis B |
| title_full | Existing problems and new advice on stage criteria of natural history for chronic hepatitis B |
| title_fullStr | Existing problems and new advice on stage criteria of natural history for chronic hepatitis B |
| title_full_unstemmed | Existing problems and new advice on stage criteria of natural history for chronic hepatitis B |
| title_short | Existing problems and new advice on stage criteria of natural history for chronic hepatitis B |
| title_sort | existing problems and new advice on stage criteria of natural history for chronic hepatitis b |
| topic | Chronic HBV infection Natural history Sstage criteria New suggestions |
| url | https://doi.org/10.1186/s12879-024-10408-x |
| work_keys_str_mv | AT tongjingxing existingproblemsandnewadviceonstagecriteriaofnaturalhistoryforchronichepatitisb |