Cinnamomum cassia Presl flavonoids prevent hyperglycemia-induced cognitive impairment via inhibiting of AGEs accumulation and oxidative stress
Cinnamomum cassia Presl (CCP) has a beneficial impact on diabetes and dementia. In this research, the underlying mechanism of flavonoids of Cinnamomum cassia Presl (CFS) on diabetes-related cognitive impairment (DRCI) were inferred by a network pharmacology approach. The conjectures of network study...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622004443 |
| _version_ | 1828067504621092864 |
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| author | Hemei Li Jinling Zhou Sitong Liu Xiuting Chen Tiantian Qin Guodong Huang Peizhen Luo Ying Hu Xing Xia |
| author_facet | Hemei Li Jinling Zhou Sitong Liu Xiuting Chen Tiantian Qin Guodong Huang Peizhen Luo Ying Hu Xing Xia |
| author_sort | Hemei Li |
| collection | DOAJ |
| description | Cinnamomum cassia Presl (CCP) has a beneficial impact on diabetes and dementia. In this research, the underlying mechanism of flavonoids of Cinnamomum cassia Presl (CFS) on diabetes-related cognitive impairment (DRCI) were inferred by a network pharmacology approach. The conjectures of network study were verified through the advanced glycation end products (AGEs) systems in vitro and the long-term diabetic rats. The experimental results showed CFS inhibited AGEs generated from nonenzymatic glycosylation reaction in vitro as well as in the brain of long-term diabetic rats in a dose-dependently manner. In morris water maze study, CFS restored the cognitive ability of diabetic rats. Moreover, the hippocampal morphology damage and oxidative stress were ameliorated by CFS, while the hippocampal level of AGEs, RAGE and pJNK/JNK were decreased significantly. These results indicated CFS may suppress AGEs accumulation via inhibiting glycosylation, and alleviating oxidative stress caused by AGEs, thereby prevents the neuronal injury and ameliorates DRCI. |
| first_indexed | 2024-04-10T23:46:32Z |
| format | Article |
| id | doaj.art-fd47210ff5f140e4a41b4254a20cc320 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-10T23:46:32Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-fd47210ff5f140e4a41b4254a20cc3202023-01-11T04:28:15ZengElsevierJournal of Functional Foods1756-46462023-01-01100105374Cinnamomum cassia Presl flavonoids prevent hyperglycemia-induced cognitive impairment via inhibiting of AGEs accumulation and oxidative stressHemei Li0Jinling Zhou1Sitong Liu2Xiuting Chen3Tiantian Qin4Guodong Huang5Peizhen Luo6Ying Hu7Xing Xia8School of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, PR ChinaSchool of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, PR China; Key Laboratory of TCM Pharmacology of Guangxi Education Department, Guangxi University of Chinese Medicine, Nanning 530200, PR ChinaWuzhou Traditional Chinese Medicine Hospital, Wuzhou 543000, PR ChinaSchool of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, PR ChinaSchool of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, PR ChinaSchool of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, PR ChinaSchool of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, PR ChinaSchool of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, PR China; Corresponding authors at: School of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, PR China (Y. Hu and X. Xia).School of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, PR China; Key Laboratory of TCM Pharmacology of Guangxi Education Department, Guangxi University of Chinese Medicine, Nanning 530200, PR China; Corresponding authors at: School of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, PR China (Y. Hu and X. Xia).Cinnamomum cassia Presl (CCP) has a beneficial impact on diabetes and dementia. In this research, the underlying mechanism of flavonoids of Cinnamomum cassia Presl (CFS) on diabetes-related cognitive impairment (DRCI) were inferred by a network pharmacology approach. The conjectures of network study were verified through the advanced glycation end products (AGEs) systems in vitro and the long-term diabetic rats. The experimental results showed CFS inhibited AGEs generated from nonenzymatic glycosylation reaction in vitro as well as in the brain of long-term diabetic rats in a dose-dependently manner. In morris water maze study, CFS restored the cognitive ability of diabetic rats. Moreover, the hippocampal morphology damage and oxidative stress were ameliorated by CFS, while the hippocampal level of AGEs, RAGE and pJNK/JNK were decreased significantly. These results indicated CFS may suppress AGEs accumulation via inhibiting glycosylation, and alleviating oxidative stress caused by AGEs, thereby prevents the neuronal injury and ameliorates DRCI.http://www.sciencedirect.com/science/article/pii/S1756464622004443Cinnamomum cassia PreslFlavonoidsHyperglycemia-induced cognitive impairmentAGEs accumulationOxidative stress |
| spellingShingle | Hemei Li Jinling Zhou Sitong Liu Xiuting Chen Tiantian Qin Guodong Huang Peizhen Luo Ying Hu Xing Xia Cinnamomum cassia Presl flavonoids prevent hyperglycemia-induced cognitive impairment via inhibiting of AGEs accumulation and oxidative stress Journal of Functional Foods Cinnamomum cassia Presl Flavonoids Hyperglycemia-induced cognitive impairment AGEs accumulation Oxidative stress |
| title | Cinnamomum cassia Presl flavonoids prevent hyperglycemia-induced cognitive impairment via inhibiting of AGEs accumulation and oxidative stress |
| title_full | Cinnamomum cassia Presl flavonoids prevent hyperglycemia-induced cognitive impairment via inhibiting of AGEs accumulation and oxidative stress |
| title_fullStr | Cinnamomum cassia Presl flavonoids prevent hyperglycemia-induced cognitive impairment via inhibiting of AGEs accumulation and oxidative stress |
| title_full_unstemmed | Cinnamomum cassia Presl flavonoids prevent hyperglycemia-induced cognitive impairment via inhibiting of AGEs accumulation and oxidative stress |
| title_short | Cinnamomum cassia Presl flavonoids prevent hyperglycemia-induced cognitive impairment via inhibiting of AGEs accumulation and oxidative stress |
| title_sort | cinnamomum cassia presl flavonoids prevent hyperglycemia induced cognitive impairment via inhibiting of ages accumulation and oxidative stress |
| topic | Cinnamomum cassia Presl Flavonoids Hyperglycemia-induced cognitive impairment AGEs accumulation Oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622004443 |
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