Follow-Up of PRRSv-Vaccinated Piglets Born from PRRSv-Vaccinated, ELISA-Seropositive and ELISA-Seronegative Sows
Vaccination against the porcine reproductive and respiratory syndrome virus (PRRSv) is widely used to prevent production losses in the swine industry. In this study, piglets born from both PRRSv-vaccinated ELISA-seropositive sows (E+ piglets) and PRRSv-vaccinated ELISA-seronegative sows (E− piglets)...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/15/2/479 |
| _version_ | 1797617825464975360 |
|---|---|
| author | Jorian Fiers Marylène Tignon Dominiek Maes Ann-Brigitte Cay |
| author_facet | Jorian Fiers Marylène Tignon Dominiek Maes Ann-Brigitte Cay |
| author_sort | Jorian Fiers |
| collection | DOAJ |
| description | Vaccination against the porcine reproductive and respiratory syndrome virus (PRRSv) is widely used to prevent production losses in the swine industry. In this study, piglets born from both PRRSv-vaccinated ELISA-seropositive sows (E+ piglets) and PRRSv-vaccinated ELISA-seronegative sows (E− piglets) were followed-up pre-vaccination, 3 weeks post-vaccination (wpv) and 8 wpv in two Belgian farrow-to-finish herds. The aim of the study was to analyze the presence of PRRSv-specific maternally-derived antibodies (MDAs) and the PRRSv vaccine response in both groups of piglets. The E− piglets lacked the presence of PRRSv-specific MDAs (0% seropositive), while these were present in the E+ piglets (97% seropositive). Due to this, the E− piglets showed a strong initial vaccine response (72–80% seroconversion) and vaccine viremia (65–75% PCR positive) at 3 wpv. In contrast, the E+ piglets showed only limited initial vaccine responses (25–61% with increased ELISA values) and vaccine viremia (30–31% PCR positive) at 3 wpv. By 8 wpv, the proportion of seropositive E− piglets (78–100%) and seropositive E+ piglets (55–90%) increased in both herds. However, a difference in vaccine viremia duration was observed between both herds at 8 wpv, with a decrease in the proportion of PCR positive piglets in herd 1 (E−: 47%; E+: 25%) and an increase in the proportion of PCR positive piglets in herd 2 (E−: 85%; E+: 92%). This study identified clear differences in the presence of PRRSv-specific maternally-derived antibodies and PRRSv vaccine responses between E− and E+ piglets. Further research is warranted to elicit the biological relevance of these observed differences. |
| first_indexed | 2024-03-11T08:01:18Z |
| format | Article |
| id | doaj.art-fd476e6d855344d6aa44af93096e9e86 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T08:01:18Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-fd476e6d855344d6aa44af93096e9e862023-11-16T23:49:34ZengMDPI AGViruses1999-49152023-02-0115247910.3390/v15020479Follow-Up of PRRSv-Vaccinated Piglets Born from PRRSv-Vaccinated, ELISA-Seropositive and ELISA-Seronegative SowsJorian Fiers0Marylène Tignon1Dominiek Maes2Ann-Brigitte Cay3Unit Viral Re-Emerging, Enzootic and Bee Diseases, Department Infectious Diseases in Animals, Sciensano, Groeselenbergstraat 99, 1180 Ukkel, BelgiumUnit Viral Re-Emerging, Enzootic and Bee Diseases, Department Infectious Diseases in Animals, Sciensano, Groeselenbergstraat 99, 1180 Ukkel, BelgiumUnit of Porcine Health Management, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, BelgiumUnit Viral Re-Emerging, Enzootic and Bee Diseases, Department Infectious Diseases in Animals, Sciensano, Groeselenbergstraat 99, 1180 Ukkel, BelgiumVaccination against the porcine reproductive and respiratory syndrome virus (PRRSv) is widely used to prevent production losses in the swine industry. In this study, piglets born from both PRRSv-vaccinated ELISA-seropositive sows (E+ piglets) and PRRSv-vaccinated ELISA-seronegative sows (E− piglets) were followed-up pre-vaccination, 3 weeks post-vaccination (wpv) and 8 wpv in two Belgian farrow-to-finish herds. The aim of the study was to analyze the presence of PRRSv-specific maternally-derived antibodies (MDAs) and the PRRSv vaccine response in both groups of piglets. The E− piglets lacked the presence of PRRSv-specific MDAs (0% seropositive), while these were present in the E+ piglets (97% seropositive). Due to this, the E− piglets showed a strong initial vaccine response (72–80% seroconversion) and vaccine viremia (65–75% PCR positive) at 3 wpv. In contrast, the E+ piglets showed only limited initial vaccine responses (25–61% with increased ELISA values) and vaccine viremia (30–31% PCR positive) at 3 wpv. By 8 wpv, the proportion of seropositive E− piglets (78–100%) and seropositive E+ piglets (55–90%) increased in both herds. However, a difference in vaccine viremia duration was observed between both herds at 8 wpv, with a decrease in the proportion of PCR positive piglets in herd 1 (E−: 47%; E+: 25%) and an increase in the proportion of PCR positive piglets in herd 2 (E−: 85%; E+: 92%). This study identified clear differences in the presence of PRRSv-specific maternally-derived antibodies and PRRSv vaccine responses between E− and E+ piglets. Further research is warranted to elicit the biological relevance of these observed differences.https://www.mdpi.com/1999-4915/15/2/479PRRSvvaccinationimmunologymaternally-derived antibodiesseroconversion |
| spellingShingle | Jorian Fiers Marylène Tignon Dominiek Maes Ann-Brigitte Cay Follow-Up of PRRSv-Vaccinated Piglets Born from PRRSv-Vaccinated, ELISA-Seropositive and ELISA-Seronegative Sows Viruses PRRSv vaccination immunology maternally-derived antibodies seroconversion |
| title | Follow-Up of PRRSv-Vaccinated Piglets Born from PRRSv-Vaccinated, ELISA-Seropositive and ELISA-Seronegative Sows |
| title_full | Follow-Up of PRRSv-Vaccinated Piglets Born from PRRSv-Vaccinated, ELISA-Seropositive and ELISA-Seronegative Sows |
| title_fullStr | Follow-Up of PRRSv-Vaccinated Piglets Born from PRRSv-Vaccinated, ELISA-Seropositive and ELISA-Seronegative Sows |
| title_full_unstemmed | Follow-Up of PRRSv-Vaccinated Piglets Born from PRRSv-Vaccinated, ELISA-Seropositive and ELISA-Seronegative Sows |
| title_short | Follow-Up of PRRSv-Vaccinated Piglets Born from PRRSv-Vaccinated, ELISA-Seropositive and ELISA-Seronegative Sows |
| title_sort | follow up of prrsv vaccinated piglets born from prrsv vaccinated elisa seropositive and elisa seronegative sows |
| topic | PRRSv vaccination immunology maternally-derived antibodies seroconversion |
| url | https://www.mdpi.com/1999-4915/15/2/479 |
| work_keys_str_mv | AT jorianfiers followupofprrsvvaccinatedpigletsbornfromprrsvvaccinatedelisaseropositiveandelisaseronegativesows AT marylenetignon followupofprrsvvaccinatedpigletsbornfromprrsvvaccinatedelisaseropositiveandelisaseronegativesows AT dominiekmaes followupofprrsvvaccinatedpigletsbornfromprrsvvaccinatedelisaseropositiveandelisaseronegativesows AT annbrigittecay followupofprrsvvaccinatedpigletsbornfromprrsvvaccinatedelisaseropositiveandelisaseronegativesows |