Molecular mechanisms of long ncRNAs in neurological disorders
Long non-coding RNAs (ncRNAs) have added an unexpected layer of complexity in the regulation of gene expression. Mounting evidence now links long ncRNAs to fundamental biological processes such as development and differentiation, and recent research shows important involvement of long ncRNAs in a va...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-03-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00048/full |
| _version_ | 1818180292380196864 |
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| author | Dubravka eVučićević Heinrich eSchrewe Ulf eAndersson Ørom |
| author_facet | Dubravka eVučićević Heinrich eSchrewe Ulf eAndersson Ørom |
| author_sort | Dubravka eVučićević |
| collection | DOAJ |
| description | Long non-coding RNAs (ncRNAs) have added an unexpected layer of complexity in the regulation of gene expression. Mounting evidence now links long ncRNAs to fundamental biological processes such as development and differentiation, and recent research shows important involvement of long ncRNAs in a variety of diseases including neurodegenerative disorders, such as Parkinson’s, Alzheimer’s, spinocerebellar ataxia and Huntington’s diseases. Furthermore, long ncRNAs are speculated to be implicated in development of psychiatric disorders such as schizophrenia and bipolar disorders. Long ncRNAs contribute to these disorders in diverse ways, from regulation of transcription to modulation of RNA processing and translation. In this review, we describe the diverse mechanisms reported for long ncRNAs, and discuss how they could mechanistically be involved in the development of neurological disorders. |
| first_indexed | 2024-12-11T21:17:27Z |
| format | Article |
| id | doaj.art-fd4958e53f5248b788d881a7c9f1f065 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-11T21:17:27Z |
| publishDate | 2014-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-fd4958e53f5248b788d881a7c9f1f0652022-12-22T00:50:33ZengFrontiers Media S.A.Frontiers in Genetics1664-80212014-03-01510.3389/fgene.2014.0004875833Molecular mechanisms of long ncRNAs in neurological disordersDubravka eVučićević0Heinrich eSchrewe1Ulf eAndersson Ørom2Max Planck Institute for Molecular GeneticsMax Planck Institute for Molecular GeneticsMax Planck Institute for Molecular GeneticsLong non-coding RNAs (ncRNAs) have added an unexpected layer of complexity in the regulation of gene expression. Mounting evidence now links long ncRNAs to fundamental biological processes such as development and differentiation, and recent research shows important involvement of long ncRNAs in a variety of diseases including neurodegenerative disorders, such as Parkinson’s, Alzheimer’s, spinocerebellar ataxia and Huntington’s diseases. Furthermore, long ncRNAs are speculated to be implicated in development of psychiatric disorders such as schizophrenia and bipolar disorders. Long ncRNAs contribute to these disorders in diverse ways, from regulation of transcription to modulation of RNA processing and translation. In this review, we describe the diverse mechanisms reported for long ncRNAs, and discuss how they could mechanistically be involved in the development of neurological disorders.http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00048/fullBrain Developmentneurological disordersncRNAprotein-RNA interactionlong noncoding RNA |
| spellingShingle | Dubravka eVučićević Heinrich eSchrewe Ulf eAndersson Ørom Molecular mechanisms of long ncRNAs in neurological disorders Frontiers in Genetics Brain Development neurological disorders ncRNA protein-RNA interaction long noncoding RNA |
| title | Molecular mechanisms of long ncRNAs in neurological disorders |
| title_full | Molecular mechanisms of long ncRNAs in neurological disorders |
| title_fullStr | Molecular mechanisms of long ncRNAs in neurological disorders |
| title_full_unstemmed | Molecular mechanisms of long ncRNAs in neurological disorders |
| title_short | Molecular mechanisms of long ncRNAs in neurological disorders |
| title_sort | molecular mechanisms of long ncrnas in neurological disorders |
| topic | Brain Development neurological disorders ncRNA protein-RNA interaction long noncoding RNA |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00048/full |
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