Trilactic glyceride regulates lipid metabolism and improves gut function in piglets
Glycerol-lactate esters are energy supplements for exercise, but effects of trilactic glyceride (TLG) on intestinal function and hepatic metabolism are unknown. We found that dietary supplementation with 0.5% TLG to weanling piglets decreased plasma concentrations of low-density lipoprotein and gamm...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2020-03-01
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| Series: | Frontiers in Bioscience-Landmark |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBL/25/7/10.2741/4858 |
| _version_ | 1828796642061451264 |
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| author | Tao Wu Kang Li Yang Lyu Dan Yi Di Zhao Lei Wang Binying Ding Yongqing Hou Guoyao Wu |
| author_facet | Tao Wu Kang Li Yang Lyu Dan Yi Di Zhao Lei Wang Binying Ding Yongqing Hou Guoyao Wu |
| author_sort | Tao Wu |
| collection | DOAJ |
| description | Glycerol-lactate esters are energy supplements for exercise, but effects of trilactic glyceride (TLG) on intestinal function and hepatic metabolism are unknown. We found that dietary supplementation with 0.5% TLG to weanling piglets decreased plasma concentrations of low-density lipoprotein and gamma-glutamyl transferase but increased those of D-xylose and high-density lipoprotein. TLG supplementation enhanced mRNA levels for fatty acid synthase (FASN) and SLC27A2 in white adipose tissue; insulin receptor in duodenum; aquaporin-8 in ileum, jejunum and colon; aquaporin-10 in duodenum and ileum; nuclear factor like-2 in jejunum and colon; glutathione S-transferase and phosphoenolpyruvate carboxykinase-1 in intestines; and abundances of claudin-1 and occludin proteins. TLG supplementation decreased mRNA levels for: hepatic hormone-sensitive lipase E, lipoprotein lipase, FASN, insulin-like growth factor-binding protein-3, and SLC27A2; and intestinal lipoprotein lipase, FASN and NADPH oxidase. Furthermore, TLG supplementation enhanced abundances of genus Bifidobacterium, while reducing abundances of family Enterobacteriaceae in ileum, colon and cecum; jejunal caspase-3 protein and diarrhea rate. In conclusion, dietary supplementation with TLG modulated lipid metabolism and alleviated diarrhea by improving intestinal function and regulating intestinal microflora in piglets. |
| first_indexed | 2024-12-12T04:26:28Z |
| format | Article |
| id | doaj.art-fd49c3cd1ad8419ca49088b07107a4e5 |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-12-12T04:26:28Z |
| publishDate | 2020-03-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-fd49c3cd1ad8419ca49088b07107a4e52022-12-22T00:38:12ZengIMR PressFrontiers in Bioscience-Landmark2768-67012020-03-012571324133610.2741/4858S2768-6701(21)00112-XTrilactic glyceride regulates lipid metabolism and improves gut function in pigletsTao Wu0Kang Li1Yang Lyu2Dan Yi3Di Zhao4Lei Wang5Binying Ding6Yongqing Hou7Guoyao Wu8Hubei Key Laboratory of Animal Nutrition and Feed Science, Engineering Research Centre of Feed Protein Resources on Agricultural By-products, Ministry of Education, Wuhan Polytechnic University, Wuhan 430023, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, Engineering Research Centre of Feed Protein Resources on Agricultural By-products, Ministry of Education, Wuhan Polytechnic University, Wuhan 430023, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, Engineering Research Centre of Feed Protein Resources on Agricultural By-products, Ministry of Education, Wuhan Polytechnic University, Wuhan 430023, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, Engineering Research Centre of Feed Protein Resources on Agricultural By-products, Ministry of Education, Wuhan Polytechnic University, Wuhan 430023, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, Engineering Research Centre of Feed Protein Resources on Agricultural By-products, Ministry of Education, Wuhan Polytechnic University, Wuhan 430023, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, Engineering Research Centre of Feed Protein Resources on Agricultural By-products, Ministry of Education, Wuhan Polytechnic University, Wuhan 430023, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, Engineering Research Centre of Feed Protein Resources on Agricultural By-products, Ministry of Education, Wuhan Polytechnic University, Wuhan 430023, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, Engineering Research Centre of Feed Protein Resources on Agricultural By-products, Ministry of Education, Wuhan Polytechnic University, Wuhan 430023, ChinaHubei Key Laboratory of Animal Nutrition and Feed Science, Engineering Research Centre of Feed Protein Resources on Agricultural By-products, Ministry of Education, Wuhan Polytechnic University, Wuhan 430023, ChinaGlycerol-lactate esters are energy supplements for exercise, but effects of trilactic glyceride (TLG) on intestinal function and hepatic metabolism are unknown. We found that dietary supplementation with 0.5% TLG to weanling piglets decreased plasma concentrations of low-density lipoprotein and gamma-glutamyl transferase but increased those of D-xylose and high-density lipoprotein. TLG supplementation enhanced mRNA levels for fatty acid synthase (FASN) and SLC27A2 in white adipose tissue; insulin receptor in duodenum; aquaporin-8 in ileum, jejunum and colon; aquaporin-10 in duodenum and ileum; nuclear factor like-2 in jejunum and colon; glutathione S-transferase and phosphoenolpyruvate carboxykinase-1 in intestines; and abundances of claudin-1 and occludin proteins. TLG supplementation decreased mRNA levels for: hepatic hormone-sensitive lipase E, lipoprotein lipase, FASN, insulin-like growth factor-binding protein-3, and SLC27A2; and intestinal lipoprotein lipase, FASN and NADPH oxidase. Furthermore, TLG supplementation enhanced abundances of genus Bifidobacterium, while reducing abundances of family Enterobacteriaceae in ileum, colon and cecum; jejunal caspase-3 protein and diarrhea rate. In conclusion, dietary supplementation with TLG modulated lipid metabolism and alleviated diarrhea by improving intestinal function and regulating intestinal microflora in piglets.https://www.imrpress.com/journal/FBL/25/7/10.2741/4858trilactic glyceride; lipid metabolism; intestinal function; weaned pigletsreview |
| spellingShingle | Tao Wu Kang Li Yang Lyu Dan Yi Di Zhao Lei Wang Binying Ding Yongqing Hou Guoyao Wu Trilactic glyceride regulates lipid metabolism and improves gut function in piglets Frontiers in Bioscience-Landmark trilactic glyceride; lipid metabolism; intestinal function; weaned piglets review |
| title | Trilactic glyceride regulates lipid metabolism and improves gut function in piglets |
| title_full | Trilactic glyceride regulates lipid metabolism and improves gut function in piglets |
| title_fullStr | Trilactic glyceride regulates lipid metabolism and improves gut function in piglets |
| title_full_unstemmed | Trilactic glyceride regulates lipid metabolism and improves gut function in piglets |
| title_short | Trilactic glyceride regulates lipid metabolism and improves gut function in piglets |
| title_sort | trilactic glyceride regulates lipid metabolism and improves gut function in piglets |
| topic | trilactic glyceride; lipid metabolism; intestinal function; weaned piglets review |
| url | https://www.imrpress.com/journal/FBL/25/7/10.2741/4858 |
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