CCR5 deficiency normalizes TIMP levels, working memory, and gamma oscillation power in APOE4 targeted replacement mice

CCR5 deficiency normalizes TIMP levels, working memory, and gamma oscillation power in APOE4 targeted replacement mice

The APOE4 allele increases the risk for Alzheimer's disease (AD) in a dose-dependent manner and is also associated with cognitive decline in non-demented elderly controls. In mice with targeted gene replacement (TR) of murine APOE with human APOE3 or APOE4, the latter show reduced neuronal dend...

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Bibliographic Details
Main Authors: Griffin A. Greco, Mitchell Rock, Matthew Amontree, Maria Fe Lanfranco, Holly Korthas, Sung Hyeok Hong, R. Scott Turner, G. William Rebeck, Katherine Conant
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Neurobiology of Disease
Subjects:
Extracellular matrix
CCR5
APOE
MMP
TIMP-1
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123000712

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