Identification of a dysfunctional microglial population in human Alzheimer’s disease cortex using novel single-cell histology image analysis

Identification of a dysfunctional microglial population in human Alzheimer’s disease cortex using novel single-cell histology image analysis

Abstract In Alzheimer’s disease (AD), microglia are affected by disease processes, but may also drive pathogenesis. AD pathology-associated microglial populations have been identified with single-cell RNA-Seq, but have not been validated in human brain tissue with anatomical context. Here, we quanti...

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Bibliographic Details
Main Authors: Molly E. V. Swanson, Emma L. Scotter, Leon C. D. Smyth, Helen C. Murray, Brigid Ryan, Clinton Turner, Richard L. M. Faull, Mike Dragunow, Maurice A. Curtis
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Acta Neuropathologica Communications
Subjects:
Microglia
Alzheimer’s disease
Tau
Amyloid beta
Dysfunction
Immunohistochemistry
Online Access:http://link.springer.com/article/10.1186/s40478-020-01047-9

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