Saracatinib inhibits necroptosis and ameliorates psoriatic inflammation by targeting MLKL

Saracatinib inhibits necroptosis and ameliorates psoriatic inflammation by targeting MLKL

Abstract Necroptosis is a kind of programmed cell death that causes the release of damage-associated molecular patterns and inflammatory disease including skin inflammation. Activation of receptor-interacting serine/threonine kinase 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like protein (MLK...

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Bibliographic Details
Main Authors: Jingyi Li, Xingfeng Liu, Yuanyuan Liu, Fangmin Huang, Jiankun Liang, Yingying Lin, Fen Hu, Jianting Feng, Zeteng Han, Yushi Chen, Xuan Chen, Qiaofa Lin, Lanqin Wu, Lisheng Li
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06514-y

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