Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation?
Lung cancer represents the primary cause of cancer death in the world. Malignant cells identification and characterization are crucial for the diagnosis and management of patients with primary or metastatic cancers. In this context, the identification of new biomarkers is essential to improve the di...
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MDPI AG
2018-07-01
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| Series: | Cells |
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| Online Access: | http://www.mdpi.com/2073-4409/7/7/78 |
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| author | Julien Guinde Diane Frankel Sophie Perrin Valérie Delecourt Nicolas Lévy Fabrice Barlesi Philippe Astoul Patrice Roll Elise Kaspi |
| author_facet | Julien Guinde Diane Frankel Sophie Perrin Valérie Delecourt Nicolas Lévy Fabrice Barlesi Philippe Astoul Patrice Roll Elise Kaspi |
| author_sort | Julien Guinde |
| collection | DOAJ |
| description | Lung cancer represents the primary cause of cancer death in the world. Malignant cells identification and characterization are crucial for the diagnosis and management of patients with primary or metastatic cancers. In this context, the identification of new biomarkers is essential to improve the differential diagnosis between cancer subtypes, to select the most appropriate therapy, and to establish prognostic correlations. Nuclear abnormalities are hallmarks of carcinoma cells and are used as cytological diagnostic criteria of malignancy. Lamins (divided into A- and B-types) are localized in the nuclear matrix comprising nuclear lamina, where they act as scaffolding protein, involved in many nuclear functions, with regulatory effects on the cell cycle and differentiation, senescence and apoptosis. Previous studies have suggested that lamins are involved in tumor development and progression with opposite results concerning their prognostic role. This review provides an overview of lamins expression in lung cancer and the relevance of these findings for disease diagnosis and prognosis. Furthermore, we discuss the link between A-type lamins expression in lung carcinoma cells and nuclear deformability, epithelial to mesenchymal transition, and metastatic potential, and which mechanisms could regulate A-type lamins expression in lung cancer, such as the microRNA miR-9. |
| first_indexed | 2024-03-12T19:23:22Z |
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| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T19:23:22Z |
| publishDate | 2018-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-fd4f7f7671d34a83a8456fe0adaf4a962023-08-02T05:03:43ZengMDPI AGCells2073-44092018-07-01777810.3390/cells7070078cells7070078Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation?Julien Guinde0Diane Frankel1Sophie Perrin2Valérie Delecourt3Nicolas Lévy4Fabrice Barlesi5Philippe Astoul6Patrice Roll7Elise Kaspi8Aix Marseille Université, INSERM, MMG, 13385 Marseille, FranceAix Marseille Université, APHM, INSERM, MMG, Hôpital la Timone, Service de Biologie Cellulaire, 13385 Marseille, FranceAix Marseille Université, INSERM, MMG, 13385 Marseille, FranceAix Marseille Université, INSERM, MMG, 13385 Marseille, FranceAix Marseille Université, APHM, INSERM, MMG, Hôpital la Timone, Département de Génétique Médicale, 13385 Marseille, FranceAix Marseille Université, APHM, CNRS, INSERM, CRCM, Multidisciplinary Oncology & Therapeutic Innovations Department, 13385 Marseille, FranceAPHM, Hôpital Nord, Department of Thoracic Oncology—Pleural Diseases—Interventional Pulmonology, CEDEX 5, 13385 Marseille, FranceAix Marseille Université, APHM, INSERM, MMG, Hôpital la Timone, Service de Biologie Cellulaire, 13385 Marseille, FranceAix Marseille Université, APHM, INSERM, MMG, Hôpital la Timone, Service de Biologie Cellulaire, 13385 Marseille, FranceLung cancer represents the primary cause of cancer death in the world. Malignant cells identification and characterization are crucial for the diagnosis and management of patients with primary or metastatic cancers. In this context, the identification of new biomarkers is essential to improve the differential diagnosis between cancer subtypes, to select the most appropriate therapy, and to establish prognostic correlations. Nuclear abnormalities are hallmarks of carcinoma cells and are used as cytological diagnostic criteria of malignancy. Lamins (divided into A- and B-types) are localized in the nuclear matrix comprising nuclear lamina, where they act as scaffolding protein, involved in many nuclear functions, with regulatory effects on the cell cycle and differentiation, senescence and apoptosis. Previous studies have suggested that lamins are involved in tumor development and progression with opposite results concerning their prognostic role. This review provides an overview of lamins expression in lung cancer and the relevance of these findings for disease diagnosis and prognosis. Furthermore, we discuss the link between A-type lamins expression in lung carcinoma cells and nuclear deformability, epithelial to mesenchymal transition, and metastatic potential, and which mechanisms could regulate A-type lamins expression in lung cancer, such as the microRNA miR-9.http://www.mdpi.com/2073-4409/7/7/78laminslung cancerlung adenocarcinomamicroRNAsmiR-9 |
| spellingShingle | Julien Guinde Diane Frankel Sophie Perrin Valérie Delecourt Nicolas Lévy Fabrice Barlesi Philippe Astoul Patrice Roll Elise Kaspi Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation? Cells lamins lung cancer lung adenocarcinoma microRNAs miR-9 |
| title | Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation? |
| title_full | Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation? |
| title_fullStr | Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation? |
| title_full_unstemmed | Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation? |
| title_short | Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation? |
| title_sort | lamins in lung cancer biomarkers and key factors for disease progression through mir 9 regulation |
| topic | lamins lung cancer lung adenocarcinoma microRNAs miR-9 |
| url | http://www.mdpi.com/2073-4409/7/7/78 |
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