Markedly increased IP-10 production by blood-brain barrier in neuromyelitis optica.

Markedly increased IP-10 production by blood-brain barrier in neuromyelitis optica.

Severe damage to the blood-brain barrier (BBB) allows anti-aquaporin 4 (AQP4) antibodies to access the astrocytic endfeet in neuromyelitis optica (NMO). In the current study, we identified the pathogenic cytokines/chemokines that are responsible for the BBB malfunction induced by NMO sera.We measure...

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Bibliographic Details
Main Authors: Fumitaka Shimizu, Hideaki Nishihara, Yasuteru Sano, Yukio Takeshita, Shiori Takahashi, Toshihiko Maeda, Toshiyuki Takahashi, Masaaki Abe, Michiaki Koga, Takashi Kanda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4374747?pdf=render

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