The effectiveness of the COVID-19 vaccines in the prevention of post-COVID conditions in children and adolescents: a systematic literature review and meta-analysis
Abstract Objective: We performed a systematic literature review and meta-analysis on the effectiveness of coronavirus disease 2019 (COVID-19) vaccination against post-COVID conditions (long COVID) in the pediatric population. Design: Systematic literature review/meta-analysis. Methods: We sear...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2024-01-01
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| Series: | Antimicrobial Stewardship & Healthcare Epidemiology |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2732494X24000421/type/journal_article |
| _version_ | 1797201154891841536 |
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| author | Maria Celidonio Gutfreund Takaaki Kobayashi Gustavo Yano Callado Isabele Pardo Mariana Kim Hsieh Vivian Lin Eli N. Perencevich Jorge L. Salinas Michael B. Edmond Eneida Mendonça Luiz Vicente Rizzo Alexandre R. Marra |
| author_facet | Maria Celidonio Gutfreund Takaaki Kobayashi Gustavo Yano Callado Isabele Pardo Mariana Kim Hsieh Vivian Lin Eli N. Perencevich Jorge L. Salinas Michael B. Edmond Eneida Mendonça Luiz Vicente Rizzo Alexandre R. Marra |
| author_sort | Maria Celidonio Gutfreund |
| collection | DOAJ |
| description |
Abstract
Objective:
We performed a systematic literature review and meta-analysis on the effectiveness of coronavirus disease 2019 (COVID-19) vaccination against post-COVID conditions (long COVID) in the pediatric population.
Design:
Systematic literature review/meta-analysis.
Methods:
We searched PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), EMBASE, Cochrane Central Register of Controlled Trials, Scopus, and Web of Science from December 1, 2019, to August 14, 2023, for studies evaluating the COVID-19 vaccine effectiveness against post-COVID conditions among vaccinated individuals < 21 years old who received at least 1 dose of COVID-19 vaccine. A post-COVID condition was defined as any symptom that was present 4 or more weeks after COVID-19 infection. We calculated the pooled diagnostic odds ratio (DOR) (95% CI) for post-COVID conditions between vaccinated and unvaccinated individuals.
Results:
Eight studies with 23,995 individuals evaluated the effect of vaccination on post-COVID conditions, of which 5 observational studies were included in the meta-analysis. The prevalence of children who did not receive COVID-19 vaccines ranged from 65% to 97%. The pooled prevalence of post-COVID conditions was 21.3% among those unvaccinated and 20.3% among those vaccinated at least once. The pooled DOR for post-COVID conditions among individuals vaccinated with at least 1 dose and those vaccinated with 2 doses were 1.07 (95% CI, 0.77–1.49) and 0.82 (95% CI, 0.63–1.08), respectively.
Conclusions:
A significant proportion of children and adolescents were unvaccinated, and the prevalence of post-COVID conditions was higher than reported in adults. While vaccination did not appear protective, conclusions were limited by the lack of randomized trials and selection bias inherent in observational studies.
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| first_indexed | 2024-04-24T07:43:02Z |
| format | Article |
| id | doaj.art-fd53b6b1229347368f7ce111f0948c3e |
| institution | Directory Open Access Journal |
| issn | 2732-494X |
| language | English |
| last_indexed | 2024-04-24T07:43:02Z |
| publishDate | 2024-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Antimicrobial Stewardship & Healthcare Epidemiology |
| spelling | doaj.art-fd53b6b1229347368f7ce111f0948c3e2024-04-19T10:15:23ZengCambridge University PressAntimicrobial Stewardship & Healthcare Epidemiology2732-494X2024-01-01410.1017/ash.2024.42The effectiveness of the COVID-19 vaccines in the prevention of post-COVID conditions in children and adolescents: a systematic literature review and meta-analysisMaria Celidonio Gutfreund0Takaaki Kobayashi1https://orcid.org/0000-0003-4751-6859Gustavo Yano Callado2https://orcid.org/0000-0001-6694-6569Isabele Pardo3Mariana Kim Hsieh4Vivian Lin5Eli N. Perencevich6Jorge L. Salinas7Michael B. Edmond8Eneida Mendonça9Luiz Vicente Rizzo10Alexandre R. Marra11https://orcid.org/0000-0002-7577-7688Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, BrazilDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USAFaculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, BrazilFaculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, BrazilFaculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, BrazilFaculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, BrazilDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA Center for Access & Delivery Research & Evaluation (CADRE), Iowa City Veterans Affairs Health Care System, Iowa City, IA, USADivision of Infectious Diseases & Geographic Medicine, Stanford University, Stanford, CA, USADepartment of Medicine, West Virginia University School of Medicine, Morgantown, WV, USADepartment of Biomedical Informatics, University of Cincinnati, Cincinnati, OH, USA Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USAFaculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, BrazilFaculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA Center for Access & Delivery Research & Evaluation (CADRE), Iowa City Veterans Affairs Health Care System, Iowa City, IA, USA Abstract Objective: We performed a systematic literature review and meta-analysis on the effectiveness of coronavirus disease 2019 (COVID-19) vaccination against post-COVID conditions (long COVID) in the pediatric population. Design: Systematic literature review/meta-analysis. Methods: We searched PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), EMBASE, Cochrane Central Register of Controlled Trials, Scopus, and Web of Science from December 1, 2019, to August 14, 2023, for studies evaluating the COVID-19 vaccine effectiveness against post-COVID conditions among vaccinated individuals < 21 years old who received at least 1 dose of COVID-19 vaccine. A post-COVID condition was defined as any symptom that was present 4 or more weeks after COVID-19 infection. We calculated the pooled diagnostic odds ratio (DOR) (95% CI) for post-COVID conditions between vaccinated and unvaccinated individuals. Results: Eight studies with 23,995 individuals evaluated the effect of vaccination on post-COVID conditions, of which 5 observational studies were included in the meta-analysis. The prevalence of children who did not receive COVID-19 vaccines ranged from 65% to 97%. The pooled prevalence of post-COVID conditions was 21.3% among those unvaccinated and 20.3% among those vaccinated at least once. The pooled DOR for post-COVID conditions among individuals vaccinated with at least 1 dose and those vaccinated with 2 doses were 1.07 (95% CI, 0.77–1.49) and 0.82 (95% CI, 0.63–1.08), respectively. Conclusions: A significant proportion of children and adolescents were unvaccinated, and the prevalence of post-COVID conditions was higher than reported in adults. While vaccination did not appear protective, conclusions were limited by the lack of randomized trials and selection bias inherent in observational studies. https://www.cambridge.org/core/product/identifier/S2732494X24000421/type/journal_article |
| spellingShingle | Maria Celidonio Gutfreund Takaaki Kobayashi Gustavo Yano Callado Isabele Pardo Mariana Kim Hsieh Vivian Lin Eli N. Perencevich Jorge L. Salinas Michael B. Edmond Eneida Mendonça Luiz Vicente Rizzo Alexandre R. Marra The effectiveness of the COVID-19 vaccines in the prevention of post-COVID conditions in children and adolescents: a systematic literature review and meta-analysis Antimicrobial Stewardship & Healthcare Epidemiology |
| title | The effectiveness of the COVID-19 vaccines in the prevention of post-COVID conditions in children and adolescents: a systematic literature review and meta-analysis |
| title_full | The effectiveness of the COVID-19 vaccines in the prevention of post-COVID conditions in children and adolescents: a systematic literature review and meta-analysis |
| title_fullStr | The effectiveness of the COVID-19 vaccines in the prevention of post-COVID conditions in children and adolescents: a systematic literature review and meta-analysis |
| title_full_unstemmed | The effectiveness of the COVID-19 vaccines in the prevention of post-COVID conditions in children and adolescents: a systematic literature review and meta-analysis |
| title_short | The effectiveness of the COVID-19 vaccines in the prevention of post-COVID conditions in children and adolescents: a systematic literature review and meta-analysis |
| title_sort | effectiveness of the covid 19 vaccines in the prevention of post covid conditions in children and adolescents a systematic literature review and meta analysis |
| url | https://www.cambridge.org/core/product/identifier/S2732494X24000421/type/journal_article |
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