Adult Vaccination as a Protective Factor for Dementia: A Meta-Analysis and Systematic Review of Population-Based Observational Studies
BackgroundCommon vaccinations may have impacts on dementia risk, but current evidence is inconsistent. We therefore investigated the association between vaccinations and dementia risk by systematic review and meta-analysis approach.MethodsWe conducted an extensive search of PubMed, Embase, Cochrane...
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| Format: | Article |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.872542/full |
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| author | Xinhui Wu Haixia Yang Sixian He Ting Xia Diang Chen Yexin Zhou Jin Liu MengSi Liu Zhen Sun |
| author_facet | Xinhui Wu Haixia Yang Sixian He Ting Xia Diang Chen Yexin Zhou Jin Liu MengSi Liu Zhen Sun |
| author_sort | Xinhui Wu |
| collection | DOAJ |
| description | BackgroundCommon vaccinations may have impacts on dementia risk, but current evidence is inconsistent. We therefore investigated the association between vaccinations and dementia risk by systematic review and meta-analysis approach.MethodsWe conducted an extensive search of PubMed, Embase, Cochrane Library, and Web of Science to identify studies that compared the risk of dementia in vaccinated versus unvaccinated populations. The adjusted hazard ratio (HR) and corresponding 95% confidence intervals (CIs) were pooled as measures.ResultsOf the 9124 records initially retrieved, 17 studies with 1857134 participants were included in our analysis. The overall pooled results showed that vaccinations were associated with a 35% lower dementia risk (HR=0.65, 95% CI: 0.60-0.71, Poverall effect < 0.001; I2 =91.8%, Pheterogeneity<0.001). All types of vaccination were associated with a trend toward reduced dementia risk, with rabies (HR=0.43), tetanus & diphtheria & pertussis (Tdap) (HR=0.69), herpes zoster (HR=0.69), influenza (HR=0.74), hepatitis A (HR=0.78), typhoid (HR=0.80), and hepatitis B (HR=0.82) vaccinations being significant. Individuals with more full vaccination types and more annual influenza vaccinations were less likely to develop dementia. Gender and age had no effect on this association.ConclusionRoutine adult vaccinations are associated with a significant reduction in dementia risk and may be an effective strategy for dementia prevention. Further research is needed to elucidate the causal effects of this association and the underlying mechanisms. |
| first_indexed | 2024-12-14T18:59:57Z |
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| id | doaj.art-fd552490bada4ae1afdb1fafd68c1820 |
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| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-14T18:59:57Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Immunology |
| spelling | doaj.art-fd552490bada4ae1afdb1fafd68c18202022-12-21T22:51:00ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-05-011310.3389/fimmu.2022.872542872542Adult Vaccination as a Protective Factor for Dementia: A Meta-Analysis and Systematic Review of Population-Based Observational StudiesXinhui Wu0Haixia Yang1Sixian He2Ting Xia3Diang Chen4Yexin Zhou5Jin Liu6MengSi Liu7Zhen Sun8Department of Geriatric, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaThe General Hospital of Western Theater Command, Chengdu, ChinaThe General Hospital of Western Theater Command, Chengdu, ChinaTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaClinical Medicine Teaching Department, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaThe First Clinical Medical College, Guangxi University of Chinese Medicine, Guangxi, ChinaXi’an Hospital of Traditional Chinese Medicine, Xi’an, ChinaHengyang Medical School, University of South China, Hengyang, ChinaHengyang Medical School, University of South China, Hengyang, ChinaBackgroundCommon vaccinations may have impacts on dementia risk, but current evidence is inconsistent. We therefore investigated the association between vaccinations and dementia risk by systematic review and meta-analysis approach.MethodsWe conducted an extensive search of PubMed, Embase, Cochrane Library, and Web of Science to identify studies that compared the risk of dementia in vaccinated versus unvaccinated populations. The adjusted hazard ratio (HR) and corresponding 95% confidence intervals (CIs) were pooled as measures.ResultsOf the 9124 records initially retrieved, 17 studies with 1857134 participants were included in our analysis. The overall pooled results showed that vaccinations were associated with a 35% lower dementia risk (HR=0.65, 95% CI: 0.60-0.71, Poverall effect < 0.001; I2 =91.8%, Pheterogeneity<0.001). All types of vaccination were associated with a trend toward reduced dementia risk, with rabies (HR=0.43), tetanus & diphtheria & pertussis (Tdap) (HR=0.69), herpes zoster (HR=0.69), influenza (HR=0.74), hepatitis A (HR=0.78), typhoid (HR=0.80), and hepatitis B (HR=0.82) vaccinations being significant. Individuals with more full vaccination types and more annual influenza vaccinations were less likely to develop dementia. Gender and age had no effect on this association.ConclusionRoutine adult vaccinations are associated with a significant reduction in dementia risk and may be an effective strategy for dementia prevention. Further research is needed to elucidate the causal effects of this association and the underlying mechanisms.https://www.frontiersin.org/articles/10.3389/fimmu.2022.872542/fullvaccinationdementiaepidemiologymeta-analysissystematic reviewprotective factor |
| spellingShingle | Xinhui Wu Haixia Yang Sixian He Ting Xia Diang Chen Yexin Zhou Jin Liu MengSi Liu Zhen Sun Adult Vaccination as a Protective Factor for Dementia: A Meta-Analysis and Systematic Review of Population-Based Observational Studies Frontiers in Immunology vaccination dementia epidemiology meta-analysis systematic review protective factor |
| title | Adult Vaccination as a Protective Factor for Dementia: A Meta-Analysis and Systematic Review of Population-Based Observational Studies |
| title_full | Adult Vaccination as a Protective Factor for Dementia: A Meta-Analysis and Systematic Review of Population-Based Observational Studies |
| title_fullStr | Adult Vaccination as a Protective Factor for Dementia: A Meta-Analysis and Systematic Review of Population-Based Observational Studies |
| title_full_unstemmed | Adult Vaccination as a Protective Factor for Dementia: A Meta-Analysis and Systematic Review of Population-Based Observational Studies |
| title_short | Adult Vaccination as a Protective Factor for Dementia: A Meta-Analysis and Systematic Review of Population-Based Observational Studies |
| title_sort | adult vaccination as a protective factor for dementia a meta analysis and systematic review of population based observational studies |
| topic | vaccination dementia epidemiology meta-analysis systematic review protective factor |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.872542/full |
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