The possible role of methylglyoxal metabolism in cancer
Tumours reprogram their metabolism to acquire an evolutionary advantage over normal cells. However, not all such metabolic pathways support energy production. An example of these metabolic pathways is the Methylglyoxal (MG) one. This pathway helps maintain the redox state, and it might act as a phos...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/14756366.2021.1972994 |
| _version_ | 1818332549412290560 |
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| author | Khalid O. Alfarouk Saad S. Alqahtani Saeed Alshahrani Jakob Morgenstern Claudiu T. Supuran Stephan J. Reshkin |
| author_facet | Khalid O. Alfarouk Saad S. Alqahtani Saeed Alshahrani Jakob Morgenstern Claudiu T. Supuran Stephan J. Reshkin |
| author_sort | Khalid O. Alfarouk |
| collection | DOAJ |
| description | Tumours reprogram their metabolism to acquire an evolutionary advantage over normal cells. However, not all such metabolic pathways support energy production. An example of these metabolic pathways is the Methylglyoxal (MG) one. This pathway helps maintain the redox state, and it might act as a phosphate sensor that monitors the intracellular phosphate levels. In this work, we discuss the biochemical step of the MG pathway and interrelate it with cancer. |
| first_indexed | 2024-12-13T13:37:31Z |
| format | Article |
| id | doaj.art-fd56f976f04e41f09b3b4e4ea3214d1b |
| institution | Directory Open Access Journal |
| issn | 1475-6366 1475-6374 |
| language | English |
| last_indexed | 2024-12-13T13:37:31Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Enzyme Inhibition and Medicinal Chemistry |
| spelling | doaj.art-fd56f976f04e41f09b3b4e4ea3214d1b2022-12-21T23:43:43ZengTaylor & Francis GroupJournal of Enzyme Inhibition and Medicinal Chemistry1475-63661475-63742021-01-013612010201510.1080/14756366.2021.19729941972994The possible role of methylglyoxal metabolism in cancerKhalid O. Alfarouk0Saad S. Alqahtani1Saeed Alshahrani2Jakob Morgenstern3Claudiu T. Supuran4Stephan J. Reshkin5Department of Evolutionary Pharmacology, and Tumor Metabolism, Hala Alfarouk Cancer CenterPharmacy Practice Research Unit, Clinical Pharmacy Department, College of Pharmacy, Jazan UniversityPharmacology and Toxicology Department, College of Pharmacy, Jazan UniversityDepartment of Internal Medicine I, Endocrinology and Metabolism, Heidelberg UniversityNeurofarba Department, Universita Degli Studi di FirenzeDepartment of Bioscience, Biotechnology and Biopharmaceutics, University of BariTumours reprogram their metabolism to acquire an evolutionary advantage over normal cells. However, not all such metabolic pathways support energy production. An example of these metabolic pathways is the Methylglyoxal (MG) one. This pathway helps maintain the redox state, and it might act as a phosphate sensor that monitors the intracellular phosphate levels. In this work, we discuss the biochemical step of the MG pathway and interrelate it with cancer.http://dx.doi.org/10.1080/14756366.2021.1972994methylglyoxalcancerenzymephredox |
| spellingShingle | Khalid O. Alfarouk Saad S. Alqahtani Saeed Alshahrani Jakob Morgenstern Claudiu T. Supuran Stephan J. Reshkin The possible role of methylglyoxal metabolism in cancer Journal of Enzyme Inhibition and Medicinal Chemistry methylglyoxal cancer enzyme ph redox |
| title | The possible role of methylglyoxal metabolism in cancer |
| title_full | The possible role of methylglyoxal metabolism in cancer |
| title_fullStr | The possible role of methylglyoxal metabolism in cancer |
| title_full_unstemmed | The possible role of methylglyoxal metabolism in cancer |
| title_short | The possible role of methylglyoxal metabolism in cancer |
| title_sort | possible role of methylglyoxal metabolism in cancer |
| topic | methylglyoxal cancer enzyme ph redox |
| url | http://dx.doi.org/10.1080/14756366.2021.1972994 |
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