Multiplexed and reproducible high content screening of live and fixed cells using Dye Drop
It is currently difficult to perform accurate single-cell assays in 384-well plates. Here the authors report Dye Drop which uses sequential density displacement and microscopy for multi-step assays on cells, and use this to collect single-cell dose-response data for small molecules in breast cancer...
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Bibliographic Details
| Main Authors: |
Caitlin E. Mills,
Kartik Subramanian,
Marc Hafner,
Mario Niepel,
Luca Gerosa,
Mirra Chung,
Chiara Victor,
Benjamin Gaudio,
Clarence Yapp,
Ajit J. Nirmal,
Nicholas Clark,
Peter K. Sorger |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-34536-7
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