Submillimeter retinoblastoma monitoring following transpupillary thermotherapy using hand-held optical coherence tomography
Abstract Background Precise, submillimeter visualization of retinal microstructures is useful for treatment monitoring of retinoblastoma. Herein, we report the use of hand-held optical coherence tomography (HH-OCT) to document a nearly-invisible retinoblastoma and monitor tumor response to transpupi...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-02-01
|
| Series: | International Journal of Retina and Vitreous |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40942-018-0112-4 |
| _version_ | 1818455606700277760 |
|---|---|
| author | Mark McGarrey Thamolwan Surakiatchanukul Carol L. Shields |
| author_facet | Mark McGarrey Thamolwan Surakiatchanukul Carol L. Shields |
| author_sort | Mark McGarrey |
| collection | DOAJ |
| description | Abstract Background Precise, submillimeter visualization of retinal microstructures is useful for treatment monitoring of retinoblastoma. Herein, we report the use of hand-held optical coherence tomography (HH-OCT) to document a nearly-invisible retinoblastoma and monitor tumor response to transpupillary thermotherapy (TTT). Case presentation A 3-week-old boy was diagnosed with unilateral familial retinoblastoma in the left eye, classified as group B, and treated with intravenous chemoreduction. At 13-month follow-up, the tumor in the left eye was regressed, and evaluation of the right eye revealed a microscopic, nearly invisible tumor measuring 372 µm in thickness and 1.51 mm in basal dimension. The tumor was confirmed on HH-OCT and the diagnosis was changed to bilateral familial retinoblastoma. The new tumor was subsequently treated with TTT and after 1 month, the tumor regressed to an optically dense scar 166 µm in thickness by HH-OCT. Five months after TTT, the scar was clinically flat and measured 73 µm. Conclusions HH-OCT has assumed a significant role in the monitoring of retinoblastoma in children. In this case, imaging with HH-OCT allowed precise localization of the tumor and submillimeter monitoring of treatment response following TTT. |
| first_indexed | 2024-12-14T22:13:27Z |
| format | Article |
| id | doaj.art-fd5889b981db467a9a0191918826e3a9 |
| institution | Directory Open Access Journal |
| issn | 2056-9920 |
| language | English |
| last_indexed | 2024-12-14T22:13:27Z |
| publishDate | 2018-02-01 |
| publisher | BMC |
| record_format | Article |
| series | International Journal of Retina and Vitreous |
| spelling | doaj.art-fd5889b981db467a9a0191918826e3a92022-12-21T22:45:41ZengBMCInternational Journal of Retina and Vitreous2056-99202018-02-01411510.1186/s40942-018-0112-4Submillimeter retinoblastoma monitoring following transpupillary thermotherapy using hand-held optical coherence tomographyMark McGarrey0Thamolwan Surakiatchanukul1Carol L. Shields2Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson UniversityOcular Oncology Service, Wills Eye Hospital, Thomas Jefferson UniversityOcular Oncology Service, Wills Eye Hospital, Thomas Jefferson UniversityAbstract Background Precise, submillimeter visualization of retinal microstructures is useful for treatment monitoring of retinoblastoma. Herein, we report the use of hand-held optical coherence tomography (HH-OCT) to document a nearly-invisible retinoblastoma and monitor tumor response to transpupillary thermotherapy (TTT). Case presentation A 3-week-old boy was diagnosed with unilateral familial retinoblastoma in the left eye, classified as group B, and treated with intravenous chemoreduction. At 13-month follow-up, the tumor in the left eye was regressed, and evaluation of the right eye revealed a microscopic, nearly invisible tumor measuring 372 µm in thickness and 1.51 mm in basal dimension. The tumor was confirmed on HH-OCT and the diagnosis was changed to bilateral familial retinoblastoma. The new tumor was subsequently treated with TTT and after 1 month, the tumor regressed to an optically dense scar 166 µm in thickness by HH-OCT. Five months after TTT, the scar was clinically flat and measured 73 µm. Conclusions HH-OCT has assumed a significant role in the monitoring of retinoblastoma in children. In this case, imaging with HH-OCT allowed precise localization of the tumor and submillimeter monitoring of treatment response following TTT.http://link.springer.com/article/10.1186/s40942-018-0112-4EyeRetinaRetinoblastomaChemoreductionRegressionTranspupillary thermotherapy |
| spellingShingle | Mark McGarrey Thamolwan Surakiatchanukul Carol L. Shields Submillimeter retinoblastoma monitoring following transpupillary thermotherapy using hand-held optical coherence tomography International Journal of Retina and Vitreous Eye Retina Retinoblastoma Chemoreduction Regression Transpupillary thermotherapy |
| title | Submillimeter retinoblastoma monitoring following transpupillary thermotherapy using hand-held optical coherence tomography |
| title_full | Submillimeter retinoblastoma monitoring following transpupillary thermotherapy using hand-held optical coherence tomography |
| title_fullStr | Submillimeter retinoblastoma monitoring following transpupillary thermotherapy using hand-held optical coherence tomography |
| title_full_unstemmed | Submillimeter retinoblastoma monitoring following transpupillary thermotherapy using hand-held optical coherence tomography |
| title_short | Submillimeter retinoblastoma monitoring following transpupillary thermotherapy using hand-held optical coherence tomography |
| title_sort | submillimeter retinoblastoma monitoring following transpupillary thermotherapy using hand held optical coherence tomography |
| topic | Eye Retina Retinoblastoma Chemoreduction Regression Transpupillary thermotherapy |
| url | http://link.springer.com/article/10.1186/s40942-018-0112-4 |
| work_keys_str_mv | AT markmcgarrey submillimeterretinoblastomamonitoringfollowingtranspupillarythermotherapyusinghandheldopticalcoherencetomography AT thamolwansurakiatchanukul submillimeterretinoblastomamonitoringfollowingtranspupillarythermotherapyusinghandheldopticalcoherencetomography AT carollshields submillimeterretinoblastomamonitoringfollowingtranspupillarythermotherapyusinghandheldopticalcoherencetomography |