Inhibitors of Plasmepsin II – Potential Antimalarial Agents
Malaria is a very serious infectious disease affecting over two billion people worldwide. Currently available antimalarial drugs are losing effectiveness due to the emergence and the spread of resistant parasite strains. In order to regain control over the disease, new treatments are urgen...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | deu |
| Published: |
Swiss Chemical Society
2004-09-01
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| Series: | CHIMIA |
| Subjects: | |
| Online Access: | https://chimia.ch/chimia/article/view/3880 |
| _version_ | 1811320044176539648 |
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| author | Christoph Boss Reto Brun Walter Fischli Christoph Binkert Solange Meyer Lars Prade Luke Harris Lionel Coppex Corinna Grisostomi Olivier Corminboeuf Jean-Marc Bourgeois Rocco Furnari Sylvia Richard-Bildstein Thomas Weller |
| author_facet | Christoph Boss Reto Brun Walter Fischli Christoph Binkert Solange Meyer Lars Prade Luke Harris Lionel Coppex Corinna Grisostomi Olivier Corminboeuf Jean-Marc Bourgeois Rocco Furnari Sylvia Richard-Bildstein Thomas Weller |
| author_sort | Christoph Boss |
| collection | DOAJ |
| description |
Malaria is a very serious infectious disease affecting over two billion people worldwide. Currently available antimalarial drugs are losing effectiveness due to the emergence and the spread of resistant parasite strains. In order to regain control over the disease, new treatments are
urgently needed. Drug discovery efforts in this direction are most likely to be successful if they target a novel mechanism of action. Such approaches will lead to antimalarial medicines that are functionally and structurally different from the existing drugs and therefore will have the potential
to overcome existing resistances. Our own efforts are focused on the aspartic protease plasmepsin II (PMII) which is a promising new drug target for future antimalarial therapies. We have found structurally simple, moderately active, non-peptide inhibitors of plasmepsin II which offer ample
opportunity for further optimization efforts.
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| first_indexed | 2024-04-13T12:52:36Z |
| format | Article |
| id | doaj.art-fd58db8601ee4bc29579ec1db0929e93 |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-04-13T12:52:36Z |
| publishDate | 2004-09-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-fd58db8601ee4bc29579ec1db0929e932022-12-22T02:46:09ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242004-09-0158910.2533/000942904777677524Inhibitors of Plasmepsin II – Potential Antimalarial AgentsChristoph BossReto BrunWalter FischliChristoph BinkertSolange MeyerLars PradeLuke HarrisLionel CoppexCorinna GrisostomiOlivier CorminboeufJean-Marc BourgeoisRocco FurnariSylvia Richard-BildsteinThomas Weller Malaria is a very serious infectious disease affecting over two billion people worldwide. Currently available antimalarial drugs are losing effectiveness due to the emergence and the spread of resistant parasite strains. In order to regain control over the disease, new treatments are urgently needed. Drug discovery efforts in this direction are most likely to be successful if they target a novel mechanism of action. Such approaches will lead to antimalarial medicines that are functionally and structurally different from the existing drugs and therefore will have the potential to overcome existing resistances. Our own efforts are focused on the aspartic protease plasmepsin II (PMII) which is a promising new drug target for future antimalarial therapies. We have found structurally simple, moderately active, non-peptide inhibitors of plasmepsin II which offer ample opportunity for further optimization efforts. https://chimia.ch/chimia/article/view/3880Aspartic proteasesEnzyme inhibitorsMalariaMedicinal chemistryPlasmepsin ii (pmii) |
| spellingShingle | Christoph Boss Reto Brun Walter Fischli Christoph Binkert Solange Meyer Lars Prade Luke Harris Lionel Coppex Corinna Grisostomi Olivier Corminboeuf Jean-Marc Bourgeois Rocco Furnari Sylvia Richard-Bildstein Thomas Weller Inhibitors of Plasmepsin II – Potential Antimalarial Agents CHIMIA Aspartic proteases Enzyme inhibitors Malaria Medicinal chemistry Plasmepsin ii (pmii) |
| title | Inhibitors of Plasmepsin II – Potential Antimalarial Agents |
| title_full | Inhibitors of Plasmepsin II – Potential Antimalarial Agents |
| title_fullStr | Inhibitors of Plasmepsin II – Potential Antimalarial Agents |
| title_full_unstemmed | Inhibitors of Plasmepsin II – Potential Antimalarial Agents |
| title_short | Inhibitors of Plasmepsin II – Potential Antimalarial Agents |
| title_sort | inhibitors of plasmepsin ii potential antimalarial agents |
| topic | Aspartic proteases Enzyme inhibitors Malaria Medicinal chemistry Plasmepsin ii (pmii) |
| url | https://chimia.ch/chimia/article/view/3880 |
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