The clinical application of critical flicker fusion frequency in demyelinating optic neuritis
Purpose: To investigate the application of critical flicker fusion frequency (CFF) in demyelinating optic neuritis (DON). Methods: A cross-sectional study. A total of 127 eyes in 69 DON patients and 63 eyes in 33 healthy control (HC) groups were included between January 2021 to September 2021 from D...
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| Format: | Article |
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Elsevier
2021-12-01
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| Series: | Advances in Ophthalmology Practice and Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667376221000111 |
| _version_ | 1828873710791032832 |
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| author | Junxia Fu Yongping Wang Shaoying Tan Guangcan Xu Huanfen Zhou Quangang Xu Shihui Wei |
| author_facet | Junxia Fu Yongping Wang Shaoying Tan Guangcan Xu Huanfen Zhou Quangang Xu Shihui Wei |
| author_sort | Junxia Fu |
| collection | DOAJ |
| description | Purpose: To investigate the application of critical flicker fusion frequency (CFF) in demyelinating optic neuritis (DON). Methods: A cross-sectional study. A total of 127 eyes in 69 DON patients and 63 eyes in 33 healthy control (HC) groups were included between January 2021 to September 2021 from Department of Ophthalmology, PLA General Hospital. Patients underwent best-corrected visual acuity (BCVA), visual field, optical coherence tomography (OCT), flash visual evoked potential (F-VEP), and CFF examinations. The affected eyes were divided into aquaporins 4 (AQP4-), myelin oligodendrocyte glycoprotein (MOG-), and double negative DON according to serum antibody; mild, moderate, severe degree visual impairment according to BCVA ≥ 0.5, 0.1-0.5, < 0.1; and 4 groups: < 1, 1 ∼< 3, 3 ∼ < 6 and > 6 months according to time interval from onset to CFF examination. One-way ANOVA was used to perform above subgroup analysis. The correlations between CFF and F-VEP peak time, peak value, BCVA and mean visual filed defect (MD) were analyzed in order via Pearson correlation analysis. Results: he trichromatic values of red, green, and yellow in DON affected eyes were 21.83 ± 9.03, 23.66 ± 10.21, 24.09 ± 10.77 Hz, respectively, which was significantly reduced compared with the HC group (t = -14.82, -14.22, -14.00; P < 0.001). The subgroup analysis showed no significant difference between different antibody subtypes (P = 0.914 <0.848 <0.604), whereas, a significant decrease of CFF trichromatic value was found in severe visual acuity impairment group (P < 0.001). There was a significant difference in CFF- trichromatic values at different time points (P < 0.001), to be specific, CFF fluctuated under 20Hz within 3 months after onset and tended to be stable around 24-28Hz. Correlation analysis showed that the peak time of F-VEP (r = -0.486, -0.515, -0.526; P < 0.001), BVCA (r = -0.640, -0.659, -0.642; P < 0.001), were negatively correlated with CFF trichromatic values, MD and CFF were positively correlated (r = 0.486, 0.453, 0.476; P = 0.003, 0.006, 0.004). Conclusions: A significant decrease of CFF value was found in DON-affected eyes, and it has a good correlation with BCVA, MD and latency of F-VEP, and can better reflect the impairment of visual function |
| first_indexed | 2024-12-13T07:21:55Z |
| format | Article |
| id | doaj.art-fd5a6fbf1d0944e98015e5a98b153214 |
| institution | Directory Open Access Journal |
| issn | 2667-3762 |
| language | English |
| last_indexed | 2024-12-13T07:21:55Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
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| series | Advances in Ophthalmology Practice and Research |
| spelling | doaj.art-fd5a6fbf1d0944e98015e5a98b1532142022-12-21T23:55:24ZengElsevierAdvances in Ophthalmology Practice and Research2667-37622021-12-0112100011The clinical application of critical flicker fusion frequency in demyelinating optic neuritisJunxia Fu0Yongping Wang1Shaoying Tan2Guangcan Xu3Huanfen Zhou4Quangang Xu5Shihui Wei6Department of Ophthalmology, The Chinese People's Liberation Army General Hospital & The Chinese People's Liberation Army Medical School, Beijing, ChinaDepartment of Ophthalmology, The Chinese People's Liberation Army General Hospital & The Chinese People's Liberation Army Medical School, Beijing, ChinaSchool of Optometry, The Hong Kong Polytechnic University, Hong Kong, ChinaDepartment of Ophthalmology, The Chinese People's Liberation Army General Hospital & The Chinese People's Liberation Army Medical School, Beijing, ChinaDepartment of Ophthalmology, The Chinese People's Liberation Army General Hospital, Beijing, ChinaDepartment of Ophthalmology, The Chinese People's Liberation Army General Hospital, Beijing, ChinaDepartment of Ophthalmology, The Chinese People's Liberation Army General Hospital, Beijing, China; Corresponding author. Department of Ophthalmology, The Chinese People's Liberation Army General Hospital, Fuxing Road No. 28, Haidian District, 100853, Beijing, China.Purpose: To investigate the application of critical flicker fusion frequency (CFF) in demyelinating optic neuritis (DON). Methods: A cross-sectional study. A total of 127 eyes in 69 DON patients and 63 eyes in 33 healthy control (HC) groups were included between January 2021 to September 2021 from Department of Ophthalmology, PLA General Hospital. Patients underwent best-corrected visual acuity (BCVA), visual field, optical coherence tomography (OCT), flash visual evoked potential (F-VEP), and CFF examinations. The affected eyes were divided into aquaporins 4 (AQP4-), myelin oligodendrocyte glycoprotein (MOG-), and double negative DON according to serum antibody; mild, moderate, severe degree visual impairment according to BCVA ≥ 0.5, 0.1-0.5, < 0.1; and 4 groups: < 1, 1 ∼< 3, 3 ∼ < 6 and > 6 months according to time interval from onset to CFF examination. One-way ANOVA was used to perform above subgroup analysis. The correlations between CFF and F-VEP peak time, peak value, BCVA and mean visual filed defect (MD) were analyzed in order via Pearson correlation analysis. Results: he trichromatic values of red, green, and yellow in DON affected eyes were 21.83 ± 9.03, 23.66 ± 10.21, 24.09 ± 10.77 Hz, respectively, which was significantly reduced compared with the HC group (t = -14.82, -14.22, -14.00; P < 0.001). The subgroup analysis showed no significant difference between different antibody subtypes (P = 0.914 <0.848 <0.604), whereas, a significant decrease of CFF trichromatic value was found in severe visual acuity impairment group (P < 0.001). There was a significant difference in CFF- trichromatic values at different time points (P < 0.001), to be specific, CFF fluctuated under 20Hz within 3 months after onset and tended to be stable around 24-28Hz. Correlation analysis showed that the peak time of F-VEP (r = -0.486, -0.515, -0.526; P < 0.001), BVCA (r = -0.640, -0.659, -0.642; P < 0.001), were negatively correlated with CFF trichromatic values, MD and CFF were positively correlated (r = 0.486, 0.453, 0.476; P = 0.003, 0.006, 0.004). Conclusions: A significant decrease of CFF value was found in DON-affected eyes, and it has a good correlation with BCVA, MD and latency of F-VEP, and can better reflect the impairment of visual functionhttp://www.sciencedirect.com/science/article/pii/S2667376221000111Critical flicker fusion frequencyDemyelinating optic neuritis |
| spellingShingle | Junxia Fu Yongping Wang Shaoying Tan Guangcan Xu Huanfen Zhou Quangang Xu Shihui Wei The clinical application of critical flicker fusion frequency in demyelinating optic neuritis Advances in Ophthalmology Practice and Research Critical flicker fusion frequency Demyelinating optic neuritis |
| title | The clinical application of critical flicker fusion frequency in demyelinating optic neuritis |
| title_full | The clinical application of critical flicker fusion frequency in demyelinating optic neuritis |
| title_fullStr | The clinical application of critical flicker fusion frequency in demyelinating optic neuritis |
| title_full_unstemmed | The clinical application of critical flicker fusion frequency in demyelinating optic neuritis |
| title_short | The clinical application of critical flicker fusion frequency in demyelinating optic neuritis |
| title_sort | clinical application of critical flicker fusion frequency in demyelinating optic neuritis |
| topic | Critical flicker fusion frequency Demyelinating optic neuritis |
| url | http://www.sciencedirect.com/science/article/pii/S2667376221000111 |
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