Characteristics and outcomes of sepsis patients with and without COVID-19
Background: The aim of this study was to describe and compare clinical characteristics and outcomes in critically ill septic patients with and without COVID-19. Methods: From February 2020 to March 2021, patients from surgical and medical ICUs at the University Hospital Dresden were screened for sep...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Journal of Infection and Public Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034122001289 |
| _version_ | 1811336548998709248 |
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| author | Lars Heubner Sara Hattenhauer Andreas Güldner Paul Leon Petrick Martin Rößler Jochen Schmitt Ralph Schneider Hanns Christoph Held Jan Mehrholz Ulf Bodechtel Maximilian Ragaller Thea Koch Peter Markus Spieth |
| author_facet | Lars Heubner Sara Hattenhauer Andreas Güldner Paul Leon Petrick Martin Rößler Jochen Schmitt Ralph Schneider Hanns Christoph Held Jan Mehrholz Ulf Bodechtel Maximilian Ragaller Thea Koch Peter Markus Spieth |
| author_sort | Lars Heubner |
| collection | DOAJ |
| description | Background: The aim of this study was to describe and compare clinical characteristics and outcomes in critically ill septic patients with and without COVID-19. Methods: From February 2020 to March 2021, patients from surgical and medical ICUs at the University Hospital Dresden were screened for sepsis. Patient characteristics and outcomes were assessed descriptively. Patient survival was analyzed using the Kaplan-Meier estimator. Associations between in-hospital mortality and risk factors were modeled using robust Poisson regression, which facilitates derivation of adjusted relative risks. Results: In 177 ICU patients treated for sepsis, COVID-19 was diagnosed and compared to 191 septic ICU patients without COVID-19. Age and sex did not differ significantly between sepsis patients with and without COVID-19, but SOFA score at ICU admission was significantly higher in septic COVID-19 patients. In-hospital mortality was significantly higher in COVID-19 patients with 59% compared to 29% in Non-COVID patients. Statistical analysis resulted in an adjusted relative risk for in-hospital mortality of 1.74 (95%-CI=1.35–2–24) in the presence of COVID-19 compared to other septic patients. Age, procalcitonin maximum value over 2 ng/ml, need for renal replacement therapy, need for invasive ventilation and septic shock were identified as additional risk factors for in-hospital mortality. Conclusion: COVID-19 was identified as independent risk factor for higher in-hospital mortality in sepsis patients. The need for invasive ventilation and renal replacement therapy as well as the presence of septic shock and higher PCT should be considered to identify high-risk patients. |
| first_indexed | 2024-04-13T17:41:06Z |
| format | Article |
| id | doaj.art-fd5ab17ae00848129fcaaa86b63ab52f |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-04-13T17:41:06Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-fd5ab17ae00848129fcaaa86b63ab52f2022-12-22T02:37:11ZengElsevierJournal of Infection and Public Health1876-03412022-06-01156670676Characteristics and outcomes of sepsis patients with and without COVID-19Lars Heubner0Sara Hattenhauer1Andreas Güldner2Paul Leon Petrick3Martin Rößler4Jochen Schmitt5Ralph Schneider6Hanns Christoph Held7Jan Mehrholz8Ulf Bodechtel9Maximilian Ragaller10Thea Koch11Peter Markus Spieth12Department of Anesthesiology and Critical Care Medicine, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, TU Dresden, Dresden, GermanyDepartment of Anesthesiology and Critical Care Medicine, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, TU Dresden, Dresden, GermanyDepartment of Anesthesiology and Critical Care Medicine, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, TU Dresden, Dresden, GermanyDepartment of Anesthesiology and Critical Care Medicine, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, TU Dresden, Dresden, GermanyCenter for Evidence-Based Healthcare (ZEGV), University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, TU Dresden, Dresden, GermanyCenter for Evidence-Based Healthcare (ZEGV), University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, TU Dresden, Dresden, GermanyDepartment of General, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, TU Dresden, Dresden, GermanyDepartment of Medicine I, University Hospital Carl Gustav Carus, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, TU Dresden, Dresden, GermanyWissenschaftliches Institut, Klinik Bavaria Kreischa, GermanyDepartment of Interdisciplinary Intensive Care Medicine and Intensive Rehabilitation, Klinik Bavaria Kreischa, GermanyDepartment of Anesthesiology and Critical Care Medicine, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, TU Dresden, Dresden, GermanyDepartment of Anesthesiology and Critical Care Medicine, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, TU Dresden, Dresden, GermanyDepartment of Anesthesiology and Critical Care Medicine, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, TU Dresden, Dresden, Germany; Correspondence to: Department of Anesthesiology and Critical Care Medicine University Hospital Carl Gustav Carus, Dresden Fetscherstraße 74, 01307 Dresden, Germany.Background: The aim of this study was to describe and compare clinical characteristics and outcomes in critically ill septic patients with and without COVID-19. Methods: From February 2020 to March 2021, patients from surgical and medical ICUs at the University Hospital Dresden were screened for sepsis. Patient characteristics and outcomes were assessed descriptively. Patient survival was analyzed using the Kaplan-Meier estimator. Associations between in-hospital mortality and risk factors were modeled using robust Poisson regression, which facilitates derivation of adjusted relative risks. Results: In 177 ICU patients treated for sepsis, COVID-19 was diagnosed and compared to 191 septic ICU patients without COVID-19. Age and sex did not differ significantly between sepsis patients with and without COVID-19, but SOFA score at ICU admission was significantly higher in septic COVID-19 patients. In-hospital mortality was significantly higher in COVID-19 patients with 59% compared to 29% in Non-COVID patients. Statistical analysis resulted in an adjusted relative risk for in-hospital mortality of 1.74 (95%-CI=1.35–2–24) in the presence of COVID-19 compared to other septic patients. Age, procalcitonin maximum value over 2 ng/ml, need for renal replacement therapy, need for invasive ventilation and septic shock were identified as additional risk factors for in-hospital mortality. Conclusion: COVID-19 was identified as independent risk factor for higher in-hospital mortality in sepsis patients. The need for invasive ventilation and renal replacement therapy as well as the presence of septic shock and higher PCT should be considered to identify high-risk patients.http://www.sciencedirect.com/science/article/pii/S1876034122001289COVID-19ARDSSepsisSeptic Shock |
| spellingShingle | Lars Heubner Sara Hattenhauer Andreas Güldner Paul Leon Petrick Martin Rößler Jochen Schmitt Ralph Schneider Hanns Christoph Held Jan Mehrholz Ulf Bodechtel Maximilian Ragaller Thea Koch Peter Markus Spieth Characteristics and outcomes of sepsis patients with and without COVID-19 Journal of Infection and Public Health COVID-19 ARDS Sepsis Septic Shock |
| title | Characteristics and outcomes of sepsis patients with and without COVID-19 |
| title_full | Characteristics and outcomes of sepsis patients with and without COVID-19 |
| title_fullStr | Characteristics and outcomes of sepsis patients with and without COVID-19 |
| title_full_unstemmed | Characteristics and outcomes of sepsis patients with and without COVID-19 |
| title_short | Characteristics and outcomes of sepsis patients with and without COVID-19 |
| title_sort | characteristics and outcomes of sepsis patients with and without covid 19 |
| topic | COVID-19 ARDS Sepsis Septic Shock |
| url | http://www.sciencedirect.com/science/article/pii/S1876034122001289 |
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