CRISPR/Cas9 and piggyBac-mediated footprint-free LRRK2-G2019S knock-in reveals neuronal complexity phenotypes and α-Synuclein modulation in dopaminergic neurons

CRISPR/Cas9 and piggyBac-mediated footprint-free LRRK2-G2019S knock-in reveals neuronal complexity phenotypes and α-Synuclein modulation in dopaminergic neurons

The p.G2019S mutation of the leucine-rich repeat kinase 2 (LRRK2) has been identified as the most prevalent genetic cause of familial and sporadic Parkinson's disease (PD). The Cre-LoxP recombination system has been used to correct the LRRK2-G2019S mutation in patient derived human induced plur...

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Bibliographic Details
Main Authors: Xiaobing Qing, Jonas Walter, Javier Jarazo, Jonathan Arias-Fuenzalida, Anna-Lena Hillje, Jens C. Schwamborn
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Stem Cell Research
Subjects:
LRRK2-G2019S
CRISPR/Cas9
piggyBac
Parkinson's disease
hiPS
α-Synuclein
Serine129 phosphorylated α-Synuclein
Online Access:http://www.sciencedirect.com/science/article/pii/S187350611730168X

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