Inhibition of furin by bone targeting superparamagnetic iron oxide nanoparticles alleviated breast cancer bone metastasis

Inhibition of furin by bone targeting superparamagnetic iron oxide nanoparticles alleviated breast cancer bone metastasis

Breast cancer bone metastasis poses significant challenge for therapeutic strategies. Inside the metastatic environment, osteoclasts and tumor cells interact synergistically to promote cancer progression. In this study, the proprotein convertase furin is targeted due to its critical roles in both tu...

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Bibliographic Details
Main Authors: Yichuan Pang, Li Su, Yao Fu, Fan Jia, Chenxi Zhang, Xiankun Cao, Wenxin He, Xueqian Kong, Jiake Xu, Jie Zhao, An Qin
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2021-03-01
Series:Bioactive Materials
Subjects:
Breast cancer metastasis
Osteoclast
Furin
Bone targeting
Iron oxide nanoparticles
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X20302140

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http://www.sciencedirect.com/science/article/pii/S2452199X20302140

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