The biosynthesis of nitric oxide from L-arginine. Nitric oxide formation features and its functional role in mitochondria
Modern data on biochemical patterns of nitric oxide biosynthesis in mammal cells from L-arginine in normoxic conditions is described. The attention of the authors is given to the results of the recent years on the structure and regulation features isoforms of NO-synthase. The emphasis is put on the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2018-02-01
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| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/2018/02/the-biosynthesis-of-nitric-oxide-from-l-arginine-nitric-oxide-formation-features-and-its-functional-role-in-mitochondria.html |
| _version_ | 1797422337157496832 |
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| author | G. V. Danylovych T. V. Bohach Yu. V. Danylovych |
| author_facet | G. V. Danylovych T. V. Bohach Yu. V. Danylovych |
| author_sort | G. V. Danylovych |
| collection | DOAJ |
| description | Modern data on biochemical patterns of nitric oxide biosynthesis in mammal cells from L-arginine in normoxic conditions is described. The attention of the authors is given to the results of the recent years on the structure and regulation features isoforms of NO-synthase. The emphasis is put on the latest conception of the compartmentalization of certain isoforms of these enzymes in cells and on the possibility of the directed transport of nitric oxide in the vascular wall. The central place in the review is devoted to issues on the endogenous formation of NO in mitochondria and its potential physiological significance. Our own results on the identification of NO in mitochondria of the uterine smooth muscle, biochemical characteristics of this process and NO possible role in Са2+ transport regulation by organelles are presented and discussed. |
| first_indexed | 2024-03-09T07:30:45Z |
| format | Article |
| id | doaj.art-fd5becdc98384006b8f4175e83f98390 |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-09T07:30:45Z |
| publishDate | 2018-02-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-fd5becdc98384006b8f4175e83f983902023-12-03T06:27:16ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032018-02-0190132410.15407/ubj90.01.003The biosynthesis of nitric oxide from L-arginine. Nitric oxide formation features and its functional role in mitochondriaG. V. Danylovych0T. V. Bohach1Yu. V. Danylovych 2Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, KyivPalladin Institute of Biochemistry, National Academy of Sciences of Ukraine, KyivPalladin Institute of Biochemistry, National Academy of Sciences of Ukraine, KyivModern data on biochemical patterns of nitric oxide biosynthesis in mammal cells from L-arginine in normoxic conditions is described. The attention of the authors is given to the results of the recent years on the structure and regulation features isoforms of NO-synthase. The emphasis is put on the latest conception of the compartmentalization of certain isoforms of these enzymes in cells and on the possibility of the directed transport of nitric oxide in the vascular wall. The central place in the review is devoted to issues on the endogenous formation of NO in mitochondria and its potential physiological significance. Our own results on the identification of NO in mitochondria of the uterine smooth muscle, biochemical characteristics of this process and NO possible role in Са2+ transport regulation by organelles are presented and discussed.http://ukrbiochemjournal.org/2018/02/the-biosynthesis-of-nitric-oxide-from-l-arginine-nitric-oxide-formation-features-and-its-functional-role-in-mitochondria.htmlcalciumcell compartmentsmitochondrianitric oxideNO-synthasessmooth muscle |
| spellingShingle | G. V. Danylovych T. V. Bohach Yu. V. Danylovych The biosynthesis of nitric oxide from L-arginine. Nitric oxide formation features and its functional role in mitochondria The Ukrainian Biochemical Journal calcium cell compartments mitochondria nitric oxide NO-synthases smooth muscle |
| title | The biosynthesis of nitric oxide from L-arginine. Nitric oxide formation features and its functional role in mitochondria |
| title_full | The biosynthesis of nitric oxide from L-arginine. Nitric oxide formation features and its functional role in mitochondria |
| title_fullStr | The biosynthesis of nitric oxide from L-arginine. Nitric oxide formation features and its functional role in mitochondria |
| title_full_unstemmed | The biosynthesis of nitric oxide from L-arginine. Nitric oxide formation features and its functional role in mitochondria |
| title_short | The biosynthesis of nitric oxide from L-arginine. Nitric oxide formation features and its functional role in mitochondria |
| title_sort | biosynthesis of nitric oxide from l arginine nitric oxide formation features and its functional role in mitochondria |
| topic | calcium cell compartments mitochondria nitric oxide NO-synthases smooth muscle |
| url | http://ukrbiochemjournal.org/2018/02/the-biosynthesis-of-nitric-oxide-from-l-arginine-nitric-oxide-formation-features-and-its-functional-role-in-mitochondria.html |
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