Features of detection of latent tuberculosis infection and tuberculosis in children from household contacts within a household (clinical case)
Aim: to demonstrate the features of detection and diagnosis of latent tuberculosis infection and pulmonary tuberculosis in children from household contacts based on own clinical observation. Materials and methods. A clinical case of own observation of pulmonary tuberculosis and latent tuberculosi...
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| Format: | Article |
| Language: | English |
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Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine
2023-06-01
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| Series: | Сучасні медичні технології |
| Subjects: | |
| Online Access: | https://zmapo-journal.com/index.php/journal/article/view/266 |
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| author | Yu. V. Myronchuk O. O. Pushnova L. I. Chernyshova O. V. Dvizov |
| author_facet | Yu. V. Myronchuk O. O. Pushnova L. I. Chernyshova O. V. Dvizov |
| author_sort | Yu. V. Myronchuk |
| collection | DOAJ |
| description | Aim: to demonstrate the features of detection and diagnosis of latent tuberculosis infection and pulmonary tuberculosis in children from household contacts based on own clinical observation.
Materials and methods. A clinical case of own observation of pulmonary tuberculosis and latent tuberculosis infection in children from household contacts who were treated in the paediatric department of the clinical base of the Phthysiatry and Pulmonology Department of Zaporizhzhia State Medical and Pharmaceutical University on Public Non-Profit Enterprise of the “Zaporizhzhia Regional Clinical and Diagnostic Center of Phthysiatry and Pulmonology” of Zaporizhzhia Regional Council.
Results. Children from household contacts were examined at ages: 8 months, 2, 3, 5 and 7 years, after their mother was diagnosed with tuberculosis (TB). All children showed an increase in tuberculin skin test, at the X-ray of the thoracic cavity organs (TCO) no changes were detected in any child. Taking into account the age of the children and their constant residence with the index patient, a decision was made to conduct an additional examination using CT scan of the TCO. Thus, three children were diagnosed with pulmonary tuberculosis – primary tuberculosis complex, and two were infected. After receiving the results of the culture test in the gastric lavage, the youngest child was found MBT, which was resistant to first-line drugs, namely isoniazid and rifampicin, which required a treatment regimen adjustment. It should be noted that the youngest girl, who was not vaccinated, had the most widespread process in the lungs compared to other children.
Conclusions. Monitoring and screening of children who have been in contact with the index patient within the household maximises the detection of additional cases of latent tuberculosis infection and pulmonary TB. The most at-risk groups are those who not vaccinated with BCG vaccine and children under 5 years of age. Early detection and timely prescription of anti-TB therapy is the key not only to effective treatment, but also to preventing the transmission of TB infection. |
| first_indexed | 2024-03-13T04:18:18Z |
| format | Article |
| id | doaj.art-fd5c1ab8531f4e06be5be33b46558554 |
| institution | Directory Open Access Journal |
| issn | 2072-9367 |
| language | English |
| last_indexed | 2024-03-13T04:18:18Z |
| publishDate | 2023-06-01 |
| publisher | Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine |
| record_format | Article |
| series | Сучасні медичні технології |
| spelling | doaj.art-fd5c1ab8531f4e06be5be33b465585542023-06-20T17:41:39ZengZaporizhia Medical Academy of Post-Graduate Education Ministry of Health of UkraineСучасні медичні технології2072-93672023-06-012505710.34287/MMT.2(57).2023.9266Features of detection of latent tuberculosis infection and tuberculosis in children from household contacts within a household (clinical case)Yu. V. Myronchuk0O. O. Pushnova1L. I. Chernyshova2O. V. Dvizov3Zaporizhzhia State Medical and Pharmaceutical University, UkrainePNE “Zaporizhzhia Regional Clinical and Diagnostic Center of Phthysiatry and Pulmonology” ZRC, UkrainePNE “Zaporizhzhia Regional Clinical and Diagnostic Center of Phthysiatry and Pulmonology” ZRC, UkrainePNE “Zaporizhzhia Regional Clinical and Diagnostic Center of Phthysiatry and Pulmonology” ZRC, UkraineAim: to demonstrate the features of detection and diagnosis of latent tuberculosis infection and pulmonary tuberculosis in children from household contacts based on own clinical observation. Materials and methods. A clinical case of own observation of pulmonary tuberculosis and latent tuberculosis infection in children from household contacts who were treated in the paediatric department of the clinical base of the Phthysiatry and Pulmonology Department of Zaporizhzhia State Medical and Pharmaceutical University on Public Non-Profit Enterprise of the “Zaporizhzhia Regional Clinical and Diagnostic Center of Phthysiatry and Pulmonology” of Zaporizhzhia Regional Council. Results. Children from household contacts were examined at ages: 8 months, 2, 3, 5 and 7 years, after their mother was diagnosed with tuberculosis (TB). All children showed an increase in tuberculin skin test, at the X-ray of the thoracic cavity organs (TCO) no changes were detected in any child. Taking into account the age of the children and their constant residence with the index patient, a decision was made to conduct an additional examination using CT scan of the TCO. Thus, three children were diagnosed with pulmonary tuberculosis – primary tuberculosis complex, and two were infected. After receiving the results of the culture test in the gastric lavage, the youngest child was found MBT, which was resistant to first-line drugs, namely isoniazid and rifampicin, which required a treatment regimen adjustment. It should be noted that the youngest girl, who was not vaccinated, had the most widespread process in the lungs compared to other children. Conclusions. Monitoring and screening of children who have been in contact with the index patient within the household maximises the detection of additional cases of latent tuberculosis infection and pulmonary TB. The most at-risk groups are those who not vaccinated with BCG vaccine and children under 5 years of age. Early detection and timely prescription of anti-TB therapy is the key not only to effective treatment, but also to preventing the transmission of TB infection.https://zmapo-journal.com/index.php/journal/article/view/266tuberculosischildrenhouseholdsunvaccinatedct scan |
| spellingShingle | Yu. V. Myronchuk O. O. Pushnova L. I. Chernyshova O. V. Dvizov Features of detection of latent tuberculosis infection and tuberculosis in children from household contacts within a household (clinical case) Сучасні медичні технології tuberculosis children households unvaccinated ct scan |
| title | Features of detection of latent tuberculosis infection and tuberculosis in children from household contacts within a household (clinical case) |
| title_full | Features of detection of latent tuberculosis infection and tuberculosis in children from household contacts within a household (clinical case) |
| title_fullStr | Features of detection of latent tuberculosis infection and tuberculosis in children from household contacts within a household (clinical case) |
| title_full_unstemmed | Features of detection of latent tuberculosis infection and tuberculosis in children from household contacts within a household (clinical case) |
| title_short | Features of detection of latent tuberculosis infection and tuberculosis in children from household contacts within a household (clinical case) |
| title_sort | features of detection of latent tuberculosis infection and tuberculosis in children from household contacts within a household clinical case |
| topic | tuberculosis children households unvaccinated ct scan |
| url | https://zmapo-journal.com/index.php/journal/article/view/266 |
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