The Golgi-localized sphingosine-1-phosphate phosphatase is indispensable for Leishmania major
Abstract Sphingosine-1-phosphate phosphatase (SPP) catalyzes the dephosphorylation of sphingosine-1-phosphate (S1P) into sphingosine, the reverse reaction of sphingosine kinase. In mammals, S1P acts as a potent bioactive molecule regulating cell proliferation, migration, and immunity. In Leishmania,...
Main Authors: | Brian Okundaye, Neha Biyani, Samrat Moitra, Kai Zhang |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-09-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-022-20249-w |
Similar Items
-
Identification of two lipid phosphatases that regulate sphingosine-1-phosphate cellular uptake and recycling
by: Mari Kono, et al.
Published: (2022-06-01) -
The leishmania ARL-1 and Golgi traffic.
by: Annelise Sahin, et al.
Published: (2008-01-01) -
The Role of Sphingolipids and Sphingosine-1-phosphate—Sphingosine-1-phosphate-receptor Signaling in Psoriasis
by: Kana Masuda-Kuroki, et al.
Published: (2023-09-01) -
OSBP is a Major Determinant of Golgi Phosphatidylinositol 4-Phosphate Homeostasis
by: Colleen P. Doyle, et al.
Published: (2024-02-01) -
Irisin Is Target of Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor-Mediated Signaling in Skeletal Muscle Cells
by: Federica Pierucci, et al.
Published: (2023-06-01)