Increased Levels of Interleukin-36 in Obesity and Type 2 Diabetes Fuel Adipose Tissue Inflammation by Inducing Its Own Expression and Release by Adipocytes and Macrophages

Increased Levels of Interleukin-36 in Obesity and Type 2 Diabetes Fuel Adipose Tissue Inflammation by Inducing Its Own Expression and Release by Adipocytes and Macrophages

Interleukin (IL)-36 is a recently described cytokine with well-known functions in the regulation of multiple inflammatory diseases. Since no data exists on how this cytokine regulates adipose tissue (AT) homeostasis, we aimed to explore the function of a specific isoform, IL-36γ, an agonist, in huma...

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Bibliographic Details
Main Authors: Gema Frühbeck, Javier Gómez-Ambrosi, Beatriz Ramírez, Amaia Mentxaka, Amaia Rodríguez, Sara Becerril, Gabriel Reina, Victor Valentí, Rafael Moncada, Camilo Silva, Victoria Catalán
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
IL-36
inflammation
obesity
adipose tissue
macrophages
fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.832185/full

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