Genetic Risk Score for Coronary Heart Disease: Review
The present review deals with the stages of creation, methods of calculation, and the use of a genetic risk score for coronary heart disease in various populations. The concept of risk factors is generally recognized on the basis of the results of epidemiological studies in the 20th century; accordi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/10/4/239 |
| _version_ | 1797547384679432192 |
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| author | Sergey Semaev Elena Shakhtshneider |
| author_facet | Sergey Semaev Elena Shakhtshneider |
| author_sort | Sergey Semaev |
| collection | DOAJ |
| description | The present review deals with the stages of creation, methods of calculation, and the use of a genetic risk score for coronary heart disease in various populations. The concept of risk factors is generally recognized on the basis of the results of epidemiological studies in the 20th century; according to this concept, the high prevalence of diseases of the circulatory system is due to lifestyle characteristics and associated risk factors. An important and relevant task for the healthcare system is to identify the population segments most susceptible to cardiovascular diseases (CVDs). The level of individual risk of an unfavorable cardiovascular prognosis is determined by genetic factors in addition to lifestyle factors. |
| first_indexed | 2024-03-10T14:43:28Z |
| format | Article |
| id | doaj.art-fd5d35e71fa540018df740c33bc9edb6 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T14:43:28Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-fd5d35e71fa540018df740c33bc9edb62023-11-20T21:38:51ZengMDPI AGJournal of Personalized Medicine2075-44262020-11-0110423910.3390/jpm10040239Genetic Risk Score for Coronary Heart Disease: ReviewSergey Semaev0Elena Shakhtshneider1Institute of Internal and Preventive Medicine—Branch of Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), Bogatkova Str. 175/1, Novosibirsk 630089, RussiaInstitute of Internal and Preventive Medicine—Branch of Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), Bogatkova Str. 175/1, Novosibirsk 630089, RussiaThe present review deals with the stages of creation, methods of calculation, and the use of a genetic risk score for coronary heart disease in various populations. The concept of risk factors is generally recognized on the basis of the results of epidemiological studies in the 20th century; according to this concept, the high prevalence of diseases of the circulatory system is due to lifestyle characteristics and associated risk factors. An important and relevant task for the healthcare system is to identify the population segments most susceptible to cardiovascular diseases (CVDs). The level of individual risk of an unfavorable cardiovascular prognosis is determined by genetic factors in addition to lifestyle factors.https://www.mdpi.com/2075-4426/10/4/239genetic risk scorerisk factormyocardial infarctioncoronary heart diseasecardiovascular disease |
| spellingShingle | Sergey Semaev Elena Shakhtshneider Genetic Risk Score for Coronary Heart Disease: Review Journal of Personalized Medicine genetic risk score risk factor myocardial infarction coronary heart disease cardiovascular disease |
| title | Genetic Risk Score for Coronary Heart Disease: Review |
| title_full | Genetic Risk Score for Coronary Heart Disease: Review |
| title_fullStr | Genetic Risk Score for Coronary Heart Disease: Review |
| title_full_unstemmed | Genetic Risk Score for Coronary Heart Disease: Review |
| title_short | Genetic Risk Score for Coronary Heart Disease: Review |
| title_sort | genetic risk score for coronary heart disease review |
| topic | genetic risk score risk factor myocardial infarction coronary heart disease cardiovascular disease |
| url | https://www.mdpi.com/2075-4426/10/4/239 |
| work_keys_str_mv | AT sergeysemaev geneticriskscoreforcoronaryheartdiseasereview AT elenashakhtshneider geneticriskscoreforcoronaryheartdiseasereview |