Compartment-specific regulation of NaV1.7 in sensory neurons after acute exposure to TNF-α

Compartment-specific regulation of NaV1.7 in sensory neurons after acute exposure to TNF-α

Summary: Tumor necrosis factor α (TNF-α) is a major pro-inflammatory cytokine, important in many diseases, that sensitizes nociceptors through its action on a variety of ion channels, including voltage-gated sodium (NaV) channels. We show here that TNF-α acutely upregulates sensory neuron excitabili...

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Bibliographic Details
Main Authors: Sidharth Tyagi, Grant P. Higerd-Rusli, Mohammad-Reza Ghovanloo, Fadia Dib-Hajj, Peng Zhao, Shujun Liu, Dong-Hyun Kim, Ji Seon Shim, Kang-Sik Park, Stephen G. Waxman, Jin-Sung Choi, Sulayman D. Dib-Hajj
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724000135

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http://www.sciencedirect.com/science/article/pii/S2211124724000135

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