EFFICIENCY OF PULMONARY TUBERCULOSIS CHEMOTHERAPY IN NEW CASES DEPENDING ON THE TIME OFDRUG RESISTANCE DETECTION
The objective of the study is to compare the efficiency of chemotherapy in new pulmonary tuberculosis patients depending on the time when multiple drug resistance was detected.Materials and subjects: 89 new patients with pulmonary tuberculosis were enrolled into the study, they all had a positive re...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2017-12-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/1065 |
| _version_ | 1826563149871972352 |
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| author | M. V. Burаkovа I. A. Vаsilyevа E. V. Vаniev T. R. Bаgdаsаryan A. G. Sаmoylovа |
| author_facet | M. V. Burаkovа I. A. Vаsilyevа E. V. Vаniev T. R. Bаgdаsаryan A. G. Sаmoylovа |
| author_sort | M. V. Burаkovа |
| collection | DOAJ |
| description | The objective of the study is to compare the efficiency of chemotherapy in new pulmonary tuberculosis patients depending on the time when multiple drug resistance was detected.Materials and subjects: 89 new patients with pulmonary tuberculosis were enrolled into the study, they all had a positive result of sputum test (at least, culture). All patients were divided into 3 groups: Group 1 (55 persons) included those with mycobacteria susceptible to rifampicin (as per the cartridge test and culture), Group 2 (16 persons) - patients resistant to rifampicin (as per the cartridge test and culture), and Group 3 (18 persons) was formed retrospectively and included patients with MDR (confirmed by culture).Results. The structure of clinical forms of tuberculosis among new cases does not depend on the drug resistance of mycobacteria. High treatment efficiency can be achieved in the new pulmonary tuberculosis cases if the initial treatment regimen was prescribed based on the results of the cartridge test with consequent correction depending on the results of the proportional method on liquid media in the automated system detecting growth of mycobacteria. If the above is provided the time of destruction healing did not depend on the drug resistance of mycobacteria, and sputum conversion was achieved in all patients of Groups 1 and 2, 71 (100 ± 1.6% ) by the 6th month of treatment. |
| first_indexed | 2024-03-12T03:30:25Z |
| format | Article |
| id | doaj.art-fd6042768a3442d68b07f06ead304a03 |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2025-03-14T09:59:23Z |
| publishDate | 2017-12-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-fd6042768a3442d68b07f06ead304a032025-03-02T11:22:27ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062017-12-019511636610.21292/2075-1230-2017-95-11-63-661065EFFICIENCY OF PULMONARY TUBERCULOSIS CHEMOTHERAPY IN NEW CASES DEPENDING ON THE TIME OFDRUG RESISTANCE DETECTIONM. V. Burаkovа0I. A. Vаsilyevа1E. V. Vаniev2T. R. Bаgdаsаryan3A. G. Sаmoylovа4Central Research Institute of TuberculosisNational Medical Research Center of Phthisiopulmonology and Infectious DiseasesCentral Research Institute of TuberculosisCentral Research Institute of TuberculosisNational Medical Research Center of Phthisiopulmonology and Infectious DiseasesThe objective of the study is to compare the efficiency of chemotherapy in new pulmonary tuberculosis patients depending on the time when multiple drug resistance was detected.Materials and subjects: 89 new patients with pulmonary tuberculosis were enrolled into the study, they all had a positive result of sputum test (at least, culture). All patients were divided into 3 groups: Group 1 (55 persons) included those with mycobacteria susceptible to rifampicin (as per the cartridge test and culture), Group 2 (16 persons) - patients resistant to rifampicin (as per the cartridge test and culture), and Group 3 (18 persons) was formed retrospectively and included patients with MDR (confirmed by culture).Results. The structure of clinical forms of tuberculosis among new cases does not depend on the drug resistance of mycobacteria. High treatment efficiency can be achieved in the new pulmonary tuberculosis cases if the initial treatment regimen was prescribed based on the results of the cartridge test with consequent correction depending on the results of the proportional method on liquid media in the automated system detecting growth of mycobacteria. If the above is provided the time of destruction healing did not depend on the drug resistance of mycobacteria, and sputum conversion was achieved in all patients of Groups 1 and 2, 71 (100 ± 1.6% ) by the 6th month of treatment.https://www.tibl-journal.com/jour/article/view/1065pulmonary tuberculosismultiple drug resistance of tuberculous mycobacteriachemotherapy of multiple drug resistant tuberculosiscartridge method |
| spellingShingle | M. V. Burаkovа I. A. Vаsilyevа E. V. Vаniev T. R. Bаgdаsаryan A. G. Sаmoylovа EFFICIENCY OF PULMONARY TUBERCULOSIS CHEMOTHERAPY IN NEW CASES DEPENDING ON THE TIME OFDRUG RESISTANCE DETECTION Туберкулез и болезни лёгких pulmonary tuberculosis multiple drug resistance of tuberculous mycobacteria chemotherapy of multiple drug resistant tuberculosis cartridge method |
| title | EFFICIENCY OF PULMONARY TUBERCULOSIS CHEMOTHERAPY IN NEW CASES DEPENDING ON THE TIME OFDRUG RESISTANCE DETECTION |
| title_full | EFFICIENCY OF PULMONARY TUBERCULOSIS CHEMOTHERAPY IN NEW CASES DEPENDING ON THE TIME OFDRUG RESISTANCE DETECTION |
| title_fullStr | EFFICIENCY OF PULMONARY TUBERCULOSIS CHEMOTHERAPY IN NEW CASES DEPENDING ON THE TIME OFDRUG RESISTANCE DETECTION |
| title_full_unstemmed | EFFICIENCY OF PULMONARY TUBERCULOSIS CHEMOTHERAPY IN NEW CASES DEPENDING ON THE TIME OFDRUG RESISTANCE DETECTION |
| title_short | EFFICIENCY OF PULMONARY TUBERCULOSIS CHEMOTHERAPY IN NEW CASES DEPENDING ON THE TIME OFDRUG RESISTANCE DETECTION |
| title_sort | efficiency of pulmonary tuberculosis chemotherapy in new cases depending on the time ofdrug resistance detection |
| topic | pulmonary tuberculosis multiple drug resistance of tuberculous mycobacteria chemotherapy of multiple drug resistant tuberculosis cartridge method |
| url | https://www.tibl-journal.com/jour/article/view/1065 |
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