Lithium: more than a mood stabilizier
Introduction Bipolar disorder (BD) is characterized by episodic changes in affect, motivation, cognition and behavior. This severe mental disorder has a prevalence of at least 1% and a high heritability of 60%-80%. The pathophysiology is still poorly understood but evidence indicate that the disord...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822010276/type/journal_article |
| _version_ | 1797616174673952768 |
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| author | A. Fraga B. Mesquita J. Facucho-Oliveira M. Albuquerque P. Espada-Santos P. Cintra S. Paulino A. Moutinho |
| author_facet | A. Fraga B. Mesquita J. Facucho-Oliveira M. Albuquerque P. Espada-Santos P. Cintra S. Paulino A. Moutinho |
| author_sort | A. Fraga |
| collection | DOAJ |
| description |
Introduction
Bipolar disorder (BD) is characterized by episodic changes in affect, motivation, cognition and behavior. This severe mental disorder has a prevalence of at least 1% and a high heritability of 60%-80%. The pathophysiology is still poorly understood but evidence indicate that the disorder relates to disturbances in front-limbic networks relevant for emotion processing and regulation. New techniques have been used to study BD and showed aberrante white matter (WM) microstructure in the corpus callosum and from-limbic pathways. However, lithium, a mood stabilizier, it looks like has celular and neuromodulatory effects.
Objectives
The authors elaborate a narrative literature review to identify the existing clinical evidence of lithium’s effect on the WM from BD patients.
Methods
Pubmed databased searched using the therms “bipolar disorder”, “white matter” and “lithium”.
Results
Lithium is a bipolar medication that confers treatment and long-term prophylaxis and been reported as having neuroprotective effects.
Studies that used new techniques such diffusion tensor imaging measures to assess white matter integrity reported a positive effect of lithium on the integrity of WM of BD patients and suggest that response to lithium treatment in BD patients is associated with normalization of WM microstructure in regions associated with emotion processing.
Conclusions
Lithium appears to positively influence the evolution of the white matter abnormalities described in BD patients however further investigation is required to strongly reinforce this potential and safety.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:37:37Z |
| format | Article |
| id | doaj.art-fd60ceb6e08d414695b2c30c52c1adf3 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:37:37Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-fd60ceb6e08d414695b2c30c52c1adf32023-11-17T05:09:27ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S405S40510.1192/j.eurpsy.2022.1027Lithium: more than a mood stabilizierA. Fraga0B. Mesquita1J. Facucho-Oliveira2M. Albuquerque3P. Espada-Santos4P. Cintra5S. Paulino6A. Moutinho7Hospital de Cascais, Psychiatry, Alcabideche, PortugalHospital de Cascais, Psychiatry, Alcabideche, PortugalHospital de Cascais, Psychiatry, Alcabideche, PortugalHospital de Cascais, Psychiatry, Alcabideche, PortugalHospital de Cascais, Psychiatry, Alcabideche, PortugalHospital de Cascais, Psychiatry, Alcabideche, PortugalHospital de Cascais, Psychiatry, Alcabideche, PortugalHospital de Cascais, Psychiatry, Alcabideche, Portugal Introduction Bipolar disorder (BD) is characterized by episodic changes in affect, motivation, cognition and behavior. This severe mental disorder has a prevalence of at least 1% and a high heritability of 60%-80%. The pathophysiology is still poorly understood but evidence indicate that the disorder relates to disturbances in front-limbic networks relevant for emotion processing and regulation. New techniques have been used to study BD and showed aberrante white matter (WM) microstructure in the corpus callosum and from-limbic pathways. However, lithium, a mood stabilizier, it looks like has celular and neuromodulatory effects. Objectives The authors elaborate a narrative literature review to identify the existing clinical evidence of lithium’s effect on the WM from BD patients. Methods Pubmed databased searched using the therms “bipolar disorder”, “white matter” and “lithium”. Results Lithium is a bipolar medication that confers treatment and long-term prophylaxis and been reported as having neuroprotective effects. Studies that used new techniques such diffusion tensor imaging measures to assess white matter integrity reported a positive effect of lithium on the integrity of WM of BD patients and suggest that response to lithium treatment in BD patients is associated with normalization of WM microstructure in regions associated with emotion processing. Conclusions Lithium appears to positively influence the evolution of the white matter abnormalities described in BD patients however further investigation is required to strongly reinforce this potential and safety. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822010276/type/journal_articlebipolar disorderNeuromodulatoryLithiumWhite matter |
| spellingShingle | A. Fraga B. Mesquita J. Facucho-Oliveira M. Albuquerque P. Espada-Santos P. Cintra S. Paulino A. Moutinho Lithium: more than a mood stabilizier European Psychiatry bipolar disorder Neuromodulatory Lithium White matter |
| title | Lithium: more than a mood stabilizier |
| title_full | Lithium: more than a mood stabilizier |
| title_fullStr | Lithium: more than a mood stabilizier |
| title_full_unstemmed | Lithium: more than a mood stabilizier |
| title_short | Lithium: more than a mood stabilizier |
| title_sort | lithium more than a mood stabilizier |
| topic | bipolar disorder Neuromodulatory Lithium White matter |
| url | https://www.cambridge.org/core/product/identifier/S0924933822010276/type/journal_article |
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