Phaeohyphomycosis in Kidney Transplant Recipients: Highlighting the Importance of Early Recognition and Surgical Debridement
Background. Fungal infections are a recognized complication of immunosuppression in solid organ transplant recipients. Phaeohyphomycoses are fungal infections caused by a diverse group of dematiaceous fungi. Methods. We share the learning points from 2 Australian cases of phaeohyphomycosis secondary...
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2023-01-01
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| Series: | Transplantation Direct |
| Online Access: | http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001430 |
| _version_ | 1797947161410797568 |
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| author | Animesh A. Singla, FRACS (Vasc) Priya Garg,, MBBS, DTM&H Juanita N. Chui,, MD David Pham,, BMed, MD Zachary J. Webb-Harvey,, MD Catriona L. Halliday,, PhD Ramesh De Silva,, MS Ahmer Hameed,, FRACS, PhD Rowan Klein Nulend,, MD Taina Lee, FRACS Germaine Wong, PhD Henry Pleass,, FRACS |
| author_facet | Animesh A. Singla, FRACS (Vasc) Priya Garg,, MBBS, DTM&H Juanita N. Chui,, MD David Pham,, BMed, MD Zachary J. Webb-Harvey,, MD Catriona L. Halliday,, PhD Ramesh De Silva,, MS Ahmer Hameed,, FRACS, PhD Rowan Klein Nulend,, MD Taina Lee, FRACS Germaine Wong, PhD Henry Pleass,, FRACS |
| author_sort | Animesh A. Singla, FRACS (Vasc) |
| collection | DOAJ |
| description | Background. Fungal infections are a recognized complication of immunosuppression in solid organ transplant recipients. Phaeohyphomycoses are fungal infections caused by a diverse group of dematiaceous fungi.
Methods. We share the learning points from 2 Australian cases of phaeohyphomycosis secondary to Phaeacreomonium species (spp). A literature review was performed using Medline, Embase, and Google Scholar to identify this condition among kidney transplant recipients.
Results. With the 2 cases reported in this article, a total of 17 cases were identified in the literature. Phaeacremonium spp is ubiquitous in humid and temperate flora, including Australia. Minor trauma is likely the source of inoculation in most cases and diagnosis is often delayed. Presently, no guidelines for management exist given the rarity of this condition. Most known cases have been treated with surgical debulking combined with long-course antifungal therapy.
Conclusion. This paper describes 2 Australian cases of phaeohyphomycosis in kidney transplant recipients. A high index of suspicion, especially in the immunosuppressed, is essential for timely diagnosis in kidney transplant recipients. There are several diagnostic and therapeutic challenges that remain with this condition. |
| first_indexed | 2024-04-10T21:22:24Z |
| format | Article |
| id | doaj.art-fd611bbd91e645f08ce697cfdc0313ab |
| institution | Directory Open Access Journal |
| issn | 2373-8731 |
| language | English |
| last_indexed | 2024-04-10T21:22:24Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Transplantation Direct |
| spelling | doaj.art-fd611bbd91e645f08ce697cfdc0313ab2023-01-20T02:41:41ZengWolters KluwerTransplantation Direct2373-87312023-01-0191e143010.1097/TXD.0000000000001430202301000-00006Phaeohyphomycosis in Kidney Transplant Recipients: Highlighting the Importance of Early Recognition and Surgical DebridementAnimesh A. Singla, FRACS (Vasc)0Priya Garg,, MBBS, DTM&H1Juanita N. Chui,, MD2David Pham,, BMed, MD3Zachary J. Webb-Harvey,, MD4Catriona L. Halliday,, PhD5Ramesh De Silva,, MS6Ahmer Hameed,, FRACS, PhD7Rowan Klein Nulend,, MD8Taina Lee, FRACS9Germaine Wong, PhD10Henry Pleass,, FRACS111 Transplant Surgery Department, Westmead Hospital, NSW, Australia.3 Center for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, NSW, Australia.2 Faculty of Medicine, Sydney University, NSW, Australia.4 Center for Infectious Diseases and Microbiology Laboratory Services, New South Wales Health Pathology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW, Australia.3 Center for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, NSW, Australia.4 Center for Infectious Diseases and Microbiology Laboratory Services, New South Wales Health Pathology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW, Australia.1 Transplant Surgery Department, Westmead Hospital, NSW, Australia.1 Transplant Surgery Department, Westmead Hospital, NSW, Australia.1 Transplant Surgery Department, Westmead Hospital, NSW, Australia.1 Transplant Surgery Department, Westmead Hospital, NSW, Australia.1 Transplant Surgery Department, Westmead Hospital, NSW, Australia.1 Transplant Surgery Department, Westmead Hospital, NSW, Australia.Background. Fungal infections are a recognized complication of immunosuppression in solid organ transplant recipients. Phaeohyphomycoses are fungal infections caused by a diverse group of dematiaceous fungi. Methods. We share the learning points from 2 Australian cases of phaeohyphomycosis secondary to Phaeacreomonium species (spp). A literature review was performed using Medline, Embase, and Google Scholar to identify this condition among kidney transplant recipients. Results. With the 2 cases reported in this article, a total of 17 cases were identified in the literature. Phaeacremonium spp is ubiquitous in humid and temperate flora, including Australia. Minor trauma is likely the source of inoculation in most cases and diagnosis is often delayed. Presently, no guidelines for management exist given the rarity of this condition. Most known cases have been treated with surgical debulking combined with long-course antifungal therapy. Conclusion. This paper describes 2 Australian cases of phaeohyphomycosis in kidney transplant recipients. A high index of suspicion, especially in the immunosuppressed, is essential for timely diagnosis in kidney transplant recipients. There are several diagnostic and therapeutic challenges that remain with this condition.http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001430 |
| spellingShingle | Animesh A. Singla, FRACS (Vasc) Priya Garg,, MBBS, DTM&H Juanita N. Chui,, MD David Pham,, BMed, MD Zachary J. Webb-Harvey,, MD Catriona L. Halliday,, PhD Ramesh De Silva,, MS Ahmer Hameed,, FRACS, PhD Rowan Klein Nulend,, MD Taina Lee, FRACS Germaine Wong, PhD Henry Pleass,, FRACS Phaeohyphomycosis in Kidney Transplant Recipients: Highlighting the Importance of Early Recognition and Surgical Debridement Transplantation Direct |
| title | Phaeohyphomycosis in Kidney Transplant Recipients: Highlighting the Importance of Early Recognition and Surgical Debridement |
| title_full | Phaeohyphomycosis in Kidney Transplant Recipients: Highlighting the Importance of Early Recognition and Surgical Debridement |
| title_fullStr | Phaeohyphomycosis in Kidney Transplant Recipients: Highlighting the Importance of Early Recognition and Surgical Debridement |
| title_full_unstemmed | Phaeohyphomycosis in Kidney Transplant Recipients: Highlighting the Importance of Early Recognition and Surgical Debridement |
| title_short | Phaeohyphomycosis in Kidney Transplant Recipients: Highlighting the Importance of Early Recognition and Surgical Debridement |
| title_sort | phaeohyphomycosis in kidney transplant recipients highlighting the importance of early recognition and surgical debridement |
| url | http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001430 |
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