Breast cancer stem cells generate immune-suppressive T regulatory cells by secreting TGFβ to evade immune-elimination

Breast cancer stem cells generate immune-suppressive T regulatory cells by secreting TGFβ to evade immune-elimination

Abstract Cancer stem cells (CSCs), being the primary contributors in tumor initiation, metastasis, and relapse, ought to have seminal roles in evasion of immune surveillance. Tumor-promoting CD4+CD25+FOXP3+ T-regulatory cells (Tregs) have been described to abolish host defense mechanisms by impeding...

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Bibliographic Details
Main Authors: Sumon Mukherjee, Sourio Chakraborty, Udit Basak, Subhadip Pati, Apratim Dutta, Saikat Dutta, Dia Roy, Shruti Banerjee, Arpan Ray, Gaurisankar Sa, Tanya Das
Format: Article
Language:English
Published: Springer 2023-12-01
Series:Discover Oncology
Subjects:
Anti-tumor immunity
Cancer stem cells
Metastasis
Microenvironment
Relapse
Stemness markers
Online Access:https://doi.org/10.1007/s12672-023-00787-z

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