Effects of Bai zhu san (Atractylodis macrocephalae) decoction on cellular immunity and Th1/Th2 cytokine ratio in a Mifepristone-induced murine abortion model
Chinese herbal medicine has been used as an anti-abortive treatment in farm animals for thousands of years. To investigate the anti-abortive functions and mechanisms of Bai zhu san (BZS) on mifepristone (RU-486)-induced abortion, pregnant mice were allocated to different groups as follows: control g...
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| Format: | Article |
| Language: | English |
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Czech Academy of Agricultural Sciences
2014-09-01
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| Series: | Veterinární Medicína |
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| Online Access: | https://vetmed.agriculturejournals.cz/artkey/vet-201409-0003_effects-of-bai-zhu-san-atractylodis-macrocephalae-decoction-on-cellular-immunity-and-th1-th2-cytokine-ratio-i.php |
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| author | M.Y. Geng F.Z. Yuan X.D. Wang X.H. Zhong |
| author_facet | M.Y. Geng F.Z. Yuan X.D. Wang X.H. Zhong |
| author_sort | M.Y. Geng |
| collection | DOAJ |
| description | Chinese herbal medicine has been used as an anti-abortive treatment in farm animals for thousands of years. To investigate the anti-abortive functions and mechanisms of Bai zhu san (BZS) on mifepristone (RU-486)-induced abortion, pregnant mice were allocated to different groups as follows: control group receiving neither RU-486 nor BZS; mice receiving RU-486 only; mice treated with both RU-486 and BZS. The results showed that the concentrations of IL-10 and IL-4 in uterine lysates were significantly higher in mice of the BZS + RU-486 group compared with the mice of the RU-486 group. The IL-10 and IL-4 levels in serum were several folds higher than that in uterus lysates. The IFN-γ concentrations in uterine lysate decreased significantly in mice of the BZS + RU-486 group vs. the RU-486 group. There were no significant differences in IL-2 concentrations between the mice of BZS + RU-486 or RU-486 groups and controls in the uterus and serum. The numbers of CD4+, CD8+T lymphocytes or macrophages in the uterus decreased in the BZS + RU-486 group compared with the RU-486 group. These results indicate that the Chinese herbal formula Bai zhu san inhibits RU-486-induced abortion and modulates the Th1/Th2 cytokine balance at the maternal-foetal interface. |
| first_indexed | 2024-04-10T08:00:19Z |
| format | Article |
| id | doaj.art-fd638becb6f34508b6b8936d1c1fd4b6 |
| institution | Directory Open Access Journal |
| issn | 0375-8427 1805-9392 |
| language | English |
| last_indexed | 2024-04-10T08:00:19Z |
| publishDate | 2014-09-01 |
| publisher | Czech Academy of Agricultural Sciences |
| record_format | Article |
| series | Veterinární Medicína |
| spelling | doaj.art-fd638becb6f34508b6b8936d1c1fd4b62023-02-23T03:50:16ZengCzech Academy of Agricultural SciencesVeterinární Medicína0375-84271805-93922014-09-0159942443210.17221/7682-VETMEDvet-201409-0003Effects of Bai zhu san (Atractylodis macrocephalae) decoction on cellular immunity and Th1/Th2 cytokine ratio in a Mifepristone-induced murine abortion modelM.Y. Geng0F.Z. Yuan1X.D. Wang2X.H. Zhong3Agricultural University of Hebei, Baoding, P.R. ChinaAgricultural University of Hebei, Baoding, P.R. ChinaAgricultural University of Hebei, Baoding, P.R. ChinaAgricultural University of Hebei, Baoding, P.R. ChinaChinese herbal medicine has been used as an anti-abortive treatment in farm animals for thousands of years. To investigate the anti-abortive functions and mechanisms of Bai zhu san (BZS) on mifepristone (RU-486)-induced abortion, pregnant mice were allocated to different groups as follows: control group receiving neither RU-486 nor BZS; mice receiving RU-486 only; mice treated with both RU-486 and BZS. The results showed that the concentrations of IL-10 and IL-4 in uterine lysates were significantly higher in mice of the BZS + RU-486 group compared with the mice of the RU-486 group. The IL-10 and IL-4 levels in serum were several folds higher than that in uterus lysates. The IFN-γ concentrations in uterine lysate decreased significantly in mice of the BZS + RU-486 group vs. the RU-486 group. There were no significant differences in IL-2 concentrations between the mice of BZS + RU-486 or RU-486 groups and controls in the uterus and serum. The numbers of CD4+, CD8+T lymphocytes or macrophages in the uterus decreased in the BZS + RU-486 group compared with the RU-486 group. These results indicate that the Chinese herbal formula Bai zhu san inhibits RU-486-induced abortion and modulates the Th1/Th2 cytokine balance at the maternal-foetal interface.https://vetmed.agriculturejournals.cz/artkey/vet-201409-0003_effects-of-bai-zhu-san-atractylodis-macrocephalae-decoction-on-cellular-immunity-and-th1-th2-cytokine-ratio-i.phpbai zhu sanmifepristonecytokineanti-abortivecd4+, cd8+t cells |
| spellingShingle | M.Y. Geng F.Z. Yuan X.D. Wang X.H. Zhong Effects of Bai zhu san (Atractylodis macrocephalae) decoction on cellular immunity and Th1/Th2 cytokine ratio in a Mifepristone-induced murine abortion model Veterinární Medicína bai zhu san mifepristone cytokine anti-abortive cd4+, cd8+t cells |
| title | Effects of Bai zhu san (Atractylodis macrocephalae) decoction on cellular immunity and Th1/Th2 cytokine ratio in a Mifepristone-induced murine abortion model |
| title_full | Effects of Bai zhu san (Atractylodis macrocephalae) decoction on cellular immunity and Th1/Th2 cytokine ratio in a Mifepristone-induced murine abortion model |
| title_fullStr | Effects of Bai zhu san (Atractylodis macrocephalae) decoction on cellular immunity and Th1/Th2 cytokine ratio in a Mifepristone-induced murine abortion model |
| title_full_unstemmed | Effects of Bai zhu san (Atractylodis macrocephalae) decoction on cellular immunity and Th1/Th2 cytokine ratio in a Mifepristone-induced murine abortion model |
| title_short | Effects of Bai zhu san (Atractylodis macrocephalae) decoction on cellular immunity and Th1/Th2 cytokine ratio in a Mifepristone-induced murine abortion model |
| title_sort | effects of bai zhu san atractylodis macrocephalae decoction on cellular immunity and th1 th2 cytokine ratio in a mifepristone induced murine abortion model |
| topic | bai zhu san mifepristone cytokine anti-abortive cd4+, cd8+t cells |
| url | https://vetmed.agriculturejournals.cz/artkey/vet-201409-0003_effects-of-bai-zhu-san-atractylodis-macrocephalae-decoction-on-cellular-immunity-and-th1-th2-cytokine-ratio-i.php |
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