Gallomyrtucommulones G and H, New Phloroglucinol Glycosides, from Bioactive Fractions of <i>Myrtus communis</i> against <i>Staphylococcus</i> Species
Myrtaceae family is a continuous source of antimicrobial agents. In the search for novel antimicrobial agents against <i>Staphylococcus</i> species, bioactive fractions of <i>Myrtus communis</i> L., growing in the Sardinia island (Italy) have been investigated. Their phytoche...
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MDPI AG
2022-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/20/7109 |
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| author | Francesca Guzzo Alexandra G. Durán Cinzia Sanna Rosangela Marasco Nicola Molfetta Elisabetta Buommino Antonio Fiorentino Brigida D’Abrosca |
| author_facet | Francesca Guzzo Alexandra G. Durán Cinzia Sanna Rosangela Marasco Nicola Molfetta Elisabetta Buommino Antonio Fiorentino Brigida D’Abrosca |
| author_sort | Francesca Guzzo |
| collection | DOAJ |
| description | Myrtaceae family is a continuous source of antimicrobial agents. In the search for novel antimicrobial agents against <i>Staphylococcus</i> species, bioactive fractions of <i>Myrtus communis</i> L., growing in the Sardinia island (Italy) have been investigated. Their phytochemical analysis led us to isolate and characterize four alkylphloroglucinol glycosides (<b>1</b>–<b>4</b>), three of them gallomyrtucommulones G–H (<b>1</b>,<b>2</b>), and myrtucommulonoside (<b>4</b>) isolated and characterized for the first time. The structures of the new and known compounds, endopreroxide G3 (<b>5</b>), myricetin-3-<i>O</i>-glycosides (<b>6</b>,<b>7</b>) were determined based on the spectroscopic evidence including 1D-/2D-NMR and HR-MS spectrometry. Enriched fractions as well as pure compounds were tested for their antimicrobial activity by broth micro-dilution assay against <i>Staphylococcus epidermidis</i> and <i>S. aureus.</i> Results reported herein demonstrated that gallomyrtucommulone G (<b>1</b>) showed a selective antimicrobial activity against both <i>S. aureus</i> strains (ATCC 29213 and 43300) until 16 μg/mL while gallomyrtucommulone D (<b>3</b>) showed the best growth inhibition value at 64 μg/mL. |
| first_indexed | 2024-03-09T19:41:59Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T19:41:59Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-fd6459cb080741f0b07782c7a661760d2023-11-24T01:37:34ZengMDPI AGMolecules1420-30492022-10-012720710910.3390/molecules27207109Gallomyrtucommulones G and H, New Phloroglucinol Glycosides, from Bioactive Fractions of <i>Myrtus communis</i> against <i>Staphylococcus</i> SpeciesFrancesca Guzzo0Alexandra G. Durán1Cinzia Sanna2Rosangela Marasco3Nicola Molfetta4Elisabetta Buommino5Antonio Fiorentino6Brigida D’Abrosca7Dipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche–DiSTABiF, Università degli Studi della Campania “Luigi Vanvitelli”, Via Vivaldi 43, 81100 Caserta, ItalyAllelopathy Group, Department of Organic Chemistry, Institute of Biomolecules (INBIO), School of Science, University of Cadiz, Campus de Excelencia Internacional (ceiA3), C/ República Saharaui n° 7, 11510 Puerto Real, SpainDepartment of Life and Environmental Sciences, University of Cagliari, Via Sant’Ignazio da Laconi 13, 09123 Cagliari, ItalyDipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche–DiSTABiF, Università degli Studi della Campania “Luigi Vanvitelli”, Via Vivaldi 43, 81100 Caserta, ItalyDipartimento di Farmacia, Università degli Studi di Napoli “Federico II”, Via Domenico Montesano 49, 80131 Napoli, ItalyDipartimento di Farmacia, Università degli Studi di Napoli “Federico II”, Via Domenico Montesano 49, 80131 Napoli, ItalyDipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche–DiSTABiF, Università degli Studi della Campania “Luigi Vanvitelli”, Via Vivaldi 43, 81100 Caserta, ItalyDipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche–DiSTABiF, Università degli Studi della Campania “Luigi Vanvitelli”, Via Vivaldi 43, 81100 Caserta, ItalyMyrtaceae family is a continuous source of antimicrobial agents. In the search for novel antimicrobial agents against <i>Staphylococcus</i> species, bioactive fractions of <i>Myrtus communis</i> L., growing in the Sardinia island (Italy) have been investigated. Their phytochemical analysis led us to isolate and characterize four alkylphloroglucinol glycosides (<b>1</b>–<b>4</b>), three of them gallomyrtucommulones G–H (<b>1</b>,<b>2</b>), and myrtucommulonoside (<b>4</b>) isolated and characterized for the first time. The structures of the new and known compounds, endopreroxide G3 (<b>5</b>), myricetin-3-<i>O</i>-glycosides (<b>6</b>,<b>7</b>) were determined based on the spectroscopic evidence including 1D-/2D-NMR and HR-MS spectrometry. Enriched fractions as well as pure compounds were tested for their antimicrobial activity by broth micro-dilution assay against <i>Staphylococcus epidermidis</i> and <i>S. aureus.</i> Results reported herein demonstrated that gallomyrtucommulone G (<b>1</b>) showed a selective antimicrobial activity against both <i>S. aureus</i> strains (ATCC 29213 and 43300) until 16 μg/mL while gallomyrtucommulone D (<b>3</b>) showed the best growth inhibition value at 64 μg/mL.https://www.mdpi.com/1420-3049/27/20/7109<i>Myrtus communis</i>gallomyrtucommulonestructural elucidationNMR analysisantimicrobial assay<i>Staphylococcus epidermidis</i> |
| spellingShingle | Francesca Guzzo Alexandra G. Durán Cinzia Sanna Rosangela Marasco Nicola Molfetta Elisabetta Buommino Antonio Fiorentino Brigida D’Abrosca Gallomyrtucommulones G and H, New Phloroglucinol Glycosides, from Bioactive Fractions of <i>Myrtus communis</i> against <i>Staphylococcus</i> Species Molecules <i>Myrtus communis</i> gallomyrtucommulone structural elucidation NMR analysis antimicrobial assay <i>Staphylococcus epidermidis</i> |
| title | Gallomyrtucommulones G and H, New Phloroglucinol Glycosides, from Bioactive Fractions of <i>Myrtus communis</i> against <i>Staphylococcus</i> Species |
| title_full | Gallomyrtucommulones G and H, New Phloroglucinol Glycosides, from Bioactive Fractions of <i>Myrtus communis</i> against <i>Staphylococcus</i> Species |
| title_fullStr | Gallomyrtucommulones G and H, New Phloroglucinol Glycosides, from Bioactive Fractions of <i>Myrtus communis</i> against <i>Staphylococcus</i> Species |
| title_full_unstemmed | Gallomyrtucommulones G and H, New Phloroglucinol Glycosides, from Bioactive Fractions of <i>Myrtus communis</i> against <i>Staphylococcus</i> Species |
| title_short | Gallomyrtucommulones G and H, New Phloroglucinol Glycosides, from Bioactive Fractions of <i>Myrtus communis</i> against <i>Staphylococcus</i> Species |
| title_sort | gallomyrtucommulones g and h new phloroglucinol glycosides from bioactive fractions of i myrtus communis i against i staphylococcus i species |
| topic | <i>Myrtus communis</i> gallomyrtucommulone structural elucidation NMR analysis antimicrobial assay <i>Staphylococcus epidermidis</i> |
| url | https://www.mdpi.com/1420-3049/27/20/7109 |
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