Correlations of coronary plaque wall thickness with wall pressure and wall pressure gradient: a representative case study
<p>Abstract</p> <p>Background</p> <p>There are two major hemodynamic stresses imposed at the blood arterial wall interface by flowing blood: the wall shear stress (WSS) acting tangentially to the wall, and the wall pressure (WP) acting normally to the wall. The role of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-07-01
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| Series: | BioMedical Engineering OnLine |
| Subjects: | |
| Online Access: | http://www.biomedical-engineering-online.com/content/11/1/43 |
| _version_ | 1818788850903810048 |
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| author | Liu Biyue Zheng Jie Bach Richard Tang Dalin |
| author_facet | Liu Biyue Zheng Jie Bach Richard Tang Dalin |
| author_sort | Liu Biyue |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>There are two major hemodynamic stresses imposed at the blood arterial wall interface by flowing blood: the wall shear stress (WSS) acting tangentially to the wall, and the wall pressure (WP) acting normally to the wall. The role of flow wall shear stress in atherosclerosis progression has been under intensive investigation, while the impact of blood pressure on plaque progression has been under-studied.</p> <p>Method</p> <p>The correlations of wall thickness (WT) with wall pressure (WP, blood pressure on the lumen wall) and spatial wall pressure gradient (WPG) in a human atherosclerotic right coronary artery were studied. The pulsatile blood flow was simulated using a three dimensional mathematical model. The blood was treated as an incompressible viscous non-Newtonian fluid. The geometry of the artery was re-constructed using an in vivo intravascular ultrasound (IVUS) 44-slice dataset obtained from a patient with consent obtained. The WT, the WP and the WPG were averaged on each slice, respectively, and Pearson correlation analysis was performed on slice averaged base. Each slice was then divided into 8 segments and averaged vessel WT, WP and WPG were collected from all 352 segments for correlation analysis. Each slice was also divided into 2 segments (inner semi-wall of bend and outer semi-wall of bend) and the correlation analysis was performed on the 88 segments.</p> <p>Results</p> <p>Under mean pressure, the Pearson coefficient for correlation between WT and WP was r = − 0.52 (p < 0.0001) by 2-segment analysis and r = − 0.81 (p < 0.0001) by slice averaged analysis, respectively. The Pearson coefficient for correlation between WT and WPG was r = 0.30 (p = 0.004) by 2-segment analysis and r = 0.45 (p = 0.002) by slice averaged analysis, respectively. The r-values corresponding to systole and diastole pressure conditions were similar.</p> <p>Conclusions</p> <p>Results from this representative case report indicated that plaque wall thickness correlated negatively with wall pressure (r = −0.81 by slice) and positively with wall pressure gradient (r = 0.45). The slice averaged WT has a strong linear relationship with the slice averaged WP. Large-scale patient studies are needed to further confirm our findings.</p> |
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| id | doaj.art-fd64c4f4734e4747b2cc25f8e8596c5f |
| institution | Directory Open Access Journal |
| issn | 1475-925X |
| language | English |
| last_indexed | 2024-12-18T14:30:14Z |
| publishDate | 2012-07-01 |
| publisher | BMC |
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| spelling | doaj.art-fd64c4f4734e4747b2cc25f8e8596c5f2022-12-21T21:04:36ZengBMCBioMedical Engineering OnLine1475-925X2012-07-011114310.1186/1475-925X-11-43Correlations of coronary plaque wall thickness with wall pressure and wall pressure gradient: a representative case studyLiu BiyueZheng JieBach RichardTang Dalin<p>Abstract</p> <p>Background</p> <p>There are two major hemodynamic stresses imposed at the blood arterial wall interface by flowing blood: the wall shear stress (WSS) acting tangentially to the wall, and the wall pressure (WP) acting normally to the wall. The role of flow wall shear stress in atherosclerosis progression has been under intensive investigation, while the impact of blood pressure on plaque progression has been under-studied.</p> <p>Method</p> <p>The correlations of wall thickness (WT) with wall pressure (WP, blood pressure on the lumen wall) and spatial wall pressure gradient (WPG) in a human atherosclerotic right coronary artery were studied. The pulsatile blood flow was simulated using a three dimensional mathematical model. The blood was treated as an incompressible viscous non-Newtonian fluid. The geometry of the artery was re-constructed using an in vivo intravascular ultrasound (IVUS) 44-slice dataset obtained from a patient with consent obtained. The WT, the WP and the WPG were averaged on each slice, respectively, and Pearson correlation analysis was performed on slice averaged base. Each slice was then divided into 8 segments and averaged vessel WT, WP and WPG were collected from all 352 segments for correlation analysis. Each slice was also divided into 2 segments (inner semi-wall of bend and outer semi-wall of bend) and the correlation analysis was performed on the 88 segments.</p> <p>Results</p> <p>Under mean pressure, the Pearson coefficient for correlation between WT and WP was r = − 0.52 (p < 0.0001) by 2-segment analysis and r = − 0.81 (p < 0.0001) by slice averaged analysis, respectively. The Pearson coefficient for correlation between WT and WPG was r = 0.30 (p = 0.004) by 2-segment analysis and r = 0.45 (p = 0.002) by slice averaged analysis, respectively. The r-values corresponding to systole and diastole pressure conditions were similar.</p> <p>Conclusions</p> <p>Results from this representative case report indicated that plaque wall thickness correlated negatively with wall pressure (r = −0.81 by slice) and positively with wall pressure gradient (r = 0.45). The slice averaged WT has a strong linear relationship with the slice averaged WP. Large-scale patient studies are needed to further confirm our findings.</p>http://www.biomedical-engineering-online.com/content/11/1/43Right coronary arteryStenosisWall thicknessWall pressurePulsatilePressure differenceWall pressure gradient |
| spellingShingle | Liu Biyue Zheng Jie Bach Richard Tang Dalin Correlations of coronary plaque wall thickness with wall pressure and wall pressure gradient: a representative case study BioMedical Engineering OnLine Right coronary artery Stenosis Wall thickness Wall pressure Pulsatile Pressure difference Wall pressure gradient |
| title | Correlations of coronary plaque wall thickness with wall pressure and wall pressure gradient: a representative case study |
| title_full | Correlations of coronary plaque wall thickness with wall pressure and wall pressure gradient: a representative case study |
| title_fullStr | Correlations of coronary plaque wall thickness with wall pressure and wall pressure gradient: a representative case study |
| title_full_unstemmed | Correlations of coronary plaque wall thickness with wall pressure and wall pressure gradient: a representative case study |
| title_short | Correlations of coronary plaque wall thickness with wall pressure and wall pressure gradient: a representative case study |
| title_sort | correlations of coronary plaque wall thickness with wall pressure and wall pressure gradient a representative case study |
| topic | Right coronary artery Stenosis Wall thickness Wall pressure Pulsatile Pressure difference Wall pressure gradient |
| url | http://www.biomedical-engineering-online.com/content/11/1/43 |
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