Knowledge mapping and research hotspots of immunotherapy in renal cell carcinoma: A text-mining study from 2002 to 2021
BackgroundRenal cell carcinoma (RCC) is one of the most lethal urological malignancies, and because early-stage RCC is asymptomatic, many patients present metastatic diseases at first diagnosis. With the development of immunotherapy, the treatment of RCC has entered a new stage and has made a series...
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| Format: | Artikel |
| Sprache: | English |
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Frontiers Media S.A.
2022-07-01
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| Schriftenreihe: | Frontiers in Immunology |
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| Online Zugang: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.969217/full |
| _version_ | 1828290706968412160 |
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| author | Kun Liu Seling Zhao Jian Li Yikun Zheng Haiyang Wu Jianqiu Kong Jianqiu Kong Zefeng Shen |
| author_facet | Kun Liu Seling Zhao Jian Li Yikun Zheng Haiyang Wu Jianqiu Kong Jianqiu Kong Zefeng Shen |
| author_sort | Kun Liu |
| collection | DOAJ |
| description | BackgroundRenal cell carcinoma (RCC) is one of the most lethal urological malignancies, and because early-stage RCC is asymptomatic, many patients present metastatic diseases at first diagnosis. With the development of immunotherapy, the treatment of RCC has entered a new stage and has made a series of progress. This study mainly outlines the knowledge map and detects the potential research hotspots by using bibliometric analysis.MethodsPublications concerning RCC immunotherapy from 2002 to 2021 in the Web of Science Core Collection were collected. Visualization and statistical analysis were mainly performed by freeware tools VOSviewer, CiteSpace, R software, and Microsoft Office Excel 2019.ResultsA total of 3,432 papers were collected in this study, and the annual number of papers and citations showed a steady growth trend. The United States is the leading country with the most high-quality publications and is also the country with the most international cooperation. The University of Texas MD Anderson Cancer Center is the most productive organization. The Journal of Clinical Oncology is the highest co-cited journal, and Brian I. Rini is both the most prolific author and the author with the largest centrality. The current research hotspots may be focused on “immune checkpoint inhibitors (ICIs),” “PD-1,” and “mammalian target of rapamycin.”ConclusionImmunotherapy has a bright future in the field of RCC treatment, among which ICIs are one of the most important research hotspots. The main future research directions of ICI-based immunotherapy may focus on combination therapy, ICI monotherapy, and the development of new predictive biomarkers. |
| first_indexed | 2024-04-13T10:39:51Z |
| format | Article |
| id | doaj.art-fd64d641f68d4a59a32c20ba0ee16bdc |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T10:39:51Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-fd64d641f68d4a59a32c20ba0ee16bdc2022-12-22T02:49:58ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-07-011310.3389/fimmu.2022.969217969217Knowledge mapping and research hotspots of immunotherapy in renal cell carcinoma: A text-mining study from 2002 to 2021Kun Liu0Seling Zhao1Jian Li2Yikun Zheng3Haiyang Wu4Jianqiu Kong5Jianqiu Kong6Zefeng Shen7Department of Urology, Xiamen Humanity Hospital, Fujian Medical University, Xiamen, ChinaDepartment of Urology, Xiamen Humanity Hospital, Fujian Medical University, Xiamen, ChinaDepartment of Urology, Xiamen Humanity Hospital, Fujian Medical University, Xiamen, ChinaDepartment of Urology, Xiamen Humanity Hospital, Fujian Medical University, Xiamen, ChinaGraduate School of Tianjin Medical University, Tianjin, ChinaDepartment of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, ChinaDepartment of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaBackgroundRenal cell carcinoma (RCC) is one of the most lethal urological malignancies, and because early-stage RCC is asymptomatic, many patients present metastatic diseases at first diagnosis. With the development of immunotherapy, the treatment of RCC has entered a new stage and has made a series of progress. This study mainly outlines the knowledge map and detects the potential research hotspots by using bibliometric analysis.MethodsPublications concerning RCC immunotherapy from 2002 to 2021 in the Web of Science Core Collection were collected. Visualization and statistical analysis were mainly performed by freeware tools VOSviewer, CiteSpace, R software, and Microsoft Office Excel 2019.ResultsA total of 3,432 papers were collected in this study, and the annual number of papers and citations showed a steady growth trend. The United States is the leading country with the most high-quality publications and is also the country with the most international cooperation. The University of Texas MD Anderson Cancer Center is the most productive organization. The Journal of Clinical Oncology is the highest co-cited journal, and Brian I. Rini is both the most prolific author and the author with the largest centrality. The current research hotspots may be focused on “immune checkpoint inhibitors (ICIs),” “PD-1,” and “mammalian target of rapamycin.”ConclusionImmunotherapy has a bright future in the field of RCC treatment, among which ICIs are one of the most important research hotspots. The main future research directions of ICI-based immunotherapy may focus on combination therapy, ICI monotherapy, and the development of new predictive biomarkers.https://www.frontiersin.org/articles/10.3389/fimmu.2022.969217/fullimmunotherapyrenal cell carcinomaimmune checkpoint inhibitorsbibliometricvisualization |
| spellingShingle | Kun Liu Seling Zhao Jian Li Yikun Zheng Haiyang Wu Jianqiu Kong Jianqiu Kong Zefeng Shen Knowledge mapping and research hotspots of immunotherapy in renal cell carcinoma: A text-mining study from 2002 to 2021 Frontiers in Immunology immunotherapy renal cell carcinoma immune checkpoint inhibitors bibliometric visualization |
| title | Knowledge mapping and research hotspots of immunotherapy in renal cell carcinoma: A text-mining study from 2002 to 2021 |
| title_full | Knowledge mapping and research hotspots of immunotherapy in renal cell carcinoma: A text-mining study from 2002 to 2021 |
| title_fullStr | Knowledge mapping and research hotspots of immunotherapy in renal cell carcinoma: A text-mining study from 2002 to 2021 |
| title_full_unstemmed | Knowledge mapping and research hotspots of immunotherapy in renal cell carcinoma: A text-mining study from 2002 to 2021 |
| title_short | Knowledge mapping and research hotspots of immunotherapy in renal cell carcinoma: A text-mining study from 2002 to 2021 |
| title_sort | knowledge mapping and research hotspots of immunotherapy in renal cell carcinoma a text mining study from 2002 to 2021 |
| topic | immunotherapy renal cell carcinoma immune checkpoint inhibitors bibliometric visualization |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.969217/full |
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