Protein and Immune Component Content of Donor Human Milk in Japan: Variation with Gestational and Postpartum Age
Donor human milk (DHM) is the second-best nutrition for preterm infants when their own mother’s milk is unavailable. The nutrient content of human milk is influenced by various factors, including gestational and postpartum age, but there are no data regarding DHM composition in Japan. The aim of thi...
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MDPI AG
2023-05-01
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| Series: | Nutrients |
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| author | Miori Tanaka Midori Date Kumiko Miura Mizuho Ito Noriko Mizuno Katsumi Mizuno |
| author_facet | Miori Tanaka Midori Date Kumiko Miura Mizuho Ito Noriko Mizuno Katsumi Mizuno |
| author_sort | Miori Tanaka |
| collection | DOAJ |
| description | Donor human milk (DHM) is the second-best nutrition for preterm infants when their own mother’s milk is unavailable. The nutrient content of human milk is influenced by various factors, including gestational and postpartum age, but there are no data regarding DHM composition in Japan. The aim of this study was to determine the protein and immune component content of DHM in Japan and to elucidate the effects of gestational and postpartum age on nutrient composition. From September 2021 to May 2022, 134 DHM samples were collected from 92 mothers of preterm and term infants. Protein concentrations in preterm DHM (<i>n</i> = 41) and term DHM (<i>n</i> = 93) were analyzed using a Miris Human Milk Analyzer. The concentrations of secretory immunoglobulin A (sIgA) and lactoferrin, major immune components, were measured using enzyme-linked immunosorbent assays. Preterm DHM exhibited higher protein content than term DHM (1.2 g/dL and 1.0 g/dL, respectively, <i>p</i> < 0.001), whereas sIgA content was higher in term DHM than in preterm DHM (110 μg/mL and 68.4 μg/mL, respectively, <i>p</i> < 0.001). Gestational age was negatively correlated with protein levels and positively correlated with sIgA and lactoferrin levels. Furthermore, a negative correlation was found between postpartum week and protein, sIgA, and lactoferrin concentrations. Our data suggest that gestational and postpartum age affects protein, sIgA, and lactoferrin concentrations in DHM. These results indicate the importance of nutritional analysis for the appropriate use of DHM in preterm infants. |
| first_indexed | 2024-03-11T03:26:58Z |
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| language | English |
| last_indexed | 2024-03-11T03:26:58Z |
| publishDate | 2023-05-01 |
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| series | Nutrients |
| spelling | doaj.art-fd6615739f3748b1b2f744e261f9cb482023-11-18T02:44:08ZengMDPI AGNutrients2072-66432023-05-011510227810.3390/nu15102278Protein and Immune Component Content of Donor Human Milk in Japan: Variation with Gestational and Postpartum AgeMiori Tanaka0Midori Date1Kumiko Miura2Mizuho Ito3Noriko Mizuno4Katsumi Mizuno5The Nippon Foundation Human Milk Bank, 17-10 Nihonbashi-koamicho, Chuo-ku, Tokyo 103-0016, JapanThe Nippon Foundation Human Milk Bank, 17-10 Nihonbashi-koamicho, Chuo-ku, Tokyo 103-0016, JapanThe Nippon Foundation Human Milk Bank, 17-10 Nihonbashi-koamicho, Chuo-ku, Tokyo 103-0016, JapanThe Nippon Foundation Human Milk Bank, 17-10 Nihonbashi-koamicho, Chuo-ku, Tokyo 103-0016, JapanJapan Human Milk Bank Association, 4-4 Nihonbashi-hisamatsucho, Chuo-ku, Tokyo 103-8480, JapanThe Nippon Foundation Human Milk Bank, 17-10 Nihonbashi-koamicho, Chuo-ku, Tokyo 103-0016, JapanDonor human milk (DHM) is the second-best nutrition for preterm infants when their own mother’s milk is unavailable. The nutrient content of human milk is influenced by various factors, including gestational and postpartum age, but there are no data regarding DHM composition in Japan. The aim of this study was to determine the protein and immune component content of DHM in Japan and to elucidate the effects of gestational and postpartum age on nutrient composition. From September 2021 to May 2022, 134 DHM samples were collected from 92 mothers of preterm and term infants. Protein concentrations in preterm DHM (<i>n</i> = 41) and term DHM (<i>n</i> = 93) were analyzed using a Miris Human Milk Analyzer. The concentrations of secretory immunoglobulin A (sIgA) and lactoferrin, major immune components, were measured using enzyme-linked immunosorbent assays. Preterm DHM exhibited higher protein content than term DHM (1.2 g/dL and 1.0 g/dL, respectively, <i>p</i> < 0.001), whereas sIgA content was higher in term DHM than in preterm DHM (110 μg/mL and 68.4 μg/mL, respectively, <i>p</i> < 0.001). Gestational age was negatively correlated with protein levels and positively correlated with sIgA and lactoferrin levels. Furthermore, a negative correlation was found between postpartum week and protein, sIgA, and lactoferrin concentrations. Our data suggest that gestational and postpartum age affects protein, sIgA, and lactoferrin concentrations in DHM. These results indicate the importance of nutritional analysis for the appropriate use of DHM in preterm infants.https://www.mdpi.com/2072-6643/15/10/2278donor human milkhuman milk bankproteinsIgAlactoferringestational age |
| spellingShingle | Miori Tanaka Midori Date Kumiko Miura Mizuho Ito Noriko Mizuno Katsumi Mizuno Protein and Immune Component Content of Donor Human Milk in Japan: Variation with Gestational and Postpartum Age Nutrients donor human milk human milk bank protein sIgA lactoferrin gestational age |
| title | Protein and Immune Component Content of Donor Human Milk in Japan: Variation with Gestational and Postpartum Age |
| title_full | Protein and Immune Component Content of Donor Human Milk in Japan: Variation with Gestational and Postpartum Age |
| title_fullStr | Protein and Immune Component Content of Donor Human Milk in Japan: Variation with Gestational and Postpartum Age |
| title_full_unstemmed | Protein and Immune Component Content of Donor Human Milk in Japan: Variation with Gestational and Postpartum Age |
| title_short | Protein and Immune Component Content of Donor Human Milk in Japan: Variation with Gestational and Postpartum Age |
| title_sort | protein and immune component content of donor human milk in japan variation with gestational and postpartum age |
| topic | donor human milk human milk bank protein sIgA lactoferrin gestational age |
| url | https://www.mdpi.com/2072-6643/15/10/2278 |
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