Exploration of the Inhibitory Potential of Varespladib for Snakebite Envenomation

Exploration of the Inhibitory Potential of Varespladib for Snakebite Envenomation

Phospholipase A2s (PLA2) is a major component of snake venom with diverse pathologic toxicities and, therefore, a potential target for antivenom therapy. Varespladib was initially designed as an inhibitor of mammal PLA2s, and was recently repurposed to a broad-spectrum inhibitor of PLA2 in snake ven...

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Bibliographic Details
Main Authors: Yiding Wang, Jing Zhang, Denghong Zhang, Huixiang Xiao, Shengwei Xiong, Chunhong Huang
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Molecules
Subjects:
antivenom
myotoxicity
phospholipase A2
varespladib
Online Access:http://www.mdpi.com/1420-3049/23/2/391

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