Vancomycin-Induced Maturation Arrest with Reactive Promyelocyte Proliferation: A Diagnostic and Therapeutic Challenge
Drug-induced leukopenia is a diagnostic and therapeutic challenge. A detailed clinical history is a must to come to a right diagnosis. Certain drugs are known to cause bone marrow suppression, leukopenia, myeloid maturation arrest, and reactive promyelocyte proliferation. Here, we report an unusual...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
2023-03-01
|
| Series: | Journal of Laboratory Physicians |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1750072 |
| _version_ | 1797336012545851392 |
|---|---|
| author | Iffat Jamal Shuchismita Shuchismita Vijayanand Choudhary |
| author_facet | Iffat Jamal Shuchismita Shuchismita Vijayanand Choudhary |
| author_sort | Iffat Jamal |
| collection | DOAJ |
| description | Drug-induced leukopenia is a diagnostic and therapeutic challenge. A detailed clinical history is a must to come to a right diagnosis. Certain drugs are known to cause bone marrow suppression, leukopenia, myeloid maturation arrest, and reactive promyelocyte proliferation. Here, we report an unusual case of vancomycin-induced maturation arrest with marked promyelocyte proliferation in a 47-year-old male patient who was being treated for novel coronavirus disease 2019 (COVID-19) infection. Most times, this reactive promyelocyte proliferation is confused with neoplastic promyelocytes, leading to incorrect diagnosis and management. |
| first_indexed | 2024-03-08T08:47:47Z |
| format | Article |
| id | doaj.art-fd6737ce51964871974b2d59098a37b1 |
| institution | Directory Open Access Journal |
| issn | 0974-2727 0974-7826 |
| language | English |
| last_indexed | 2024-03-08T08:47:47Z |
| publishDate | 2023-03-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Journal of Laboratory Physicians |
| spelling | doaj.art-fd6737ce51964871974b2d59098a37b12024-02-01T15:07:32ZengThieme Medical and Scientific Publishers Pvt. Ltd.Journal of Laboratory Physicians0974-27270974-78262023-03-01150114915110.1055/s-0042-1750072Vancomycin-Induced Maturation Arrest with Reactive Promyelocyte Proliferation: A Diagnostic and Therapeutic ChallengeIffat Jamal0https://orcid.org/0000-0001-5574-5569Shuchismita Shuchismita1Vijayanand Choudhary2Department of Hematology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, IndiaDepartment of Hematology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, IndiaDepartment of Hematology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, IndiaDrug-induced leukopenia is a diagnostic and therapeutic challenge. A detailed clinical history is a must to come to a right diagnosis. Certain drugs are known to cause bone marrow suppression, leukopenia, myeloid maturation arrest, and reactive promyelocyte proliferation. Here, we report an unusual case of vancomycin-induced maturation arrest with marked promyelocyte proliferation in a 47-year-old male patient who was being treated for novel coronavirus disease 2019 (COVID-19) infection. Most times, this reactive promyelocyte proliferation is confused with neoplastic promyelocytes, leading to incorrect diagnosis and management.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1750072vancomycinmaturation arrestpromyelocyteproliferationbone marrow |
| spellingShingle | Iffat Jamal Shuchismita Shuchismita Vijayanand Choudhary Vancomycin-Induced Maturation Arrest with Reactive Promyelocyte Proliferation: A Diagnostic and Therapeutic Challenge Journal of Laboratory Physicians vancomycin maturation arrest promyelocyte proliferation bone marrow |
| title | Vancomycin-Induced Maturation Arrest with Reactive Promyelocyte Proliferation: A Diagnostic and Therapeutic Challenge |
| title_full | Vancomycin-Induced Maturation Arrest with Reactive Promyelocyte Proliferation: A Diagnostic and Therapeutic Challenge |
| title_fullStr | Vancomycin-Induced Maturation Arrest with Reactive Promyelocyte Proliferation: A Diagnostic and Therapeutic Challenge |
| title_full_unstemmed | Vancomycin-Induced Maturation Arrest with Reactive Promyelocyte Proliferation: A Diagnostic and Therapeutic Challenge |
| title_short | Vancomycin-Induced Maturation Arrest with Reactive Promyelocyte Proliferation: A Diagnostic and Therapeutic Challenge |
| title_sort | vancomycin induced maturation arrest with reactive promyelocyte proliferation a diagnostic and therapeutic challenge |
| topic | vancomycin maturation arrest promyelocyte proliferation bone marrow |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1750072 |
| work_keys_str_mv | AT iffatjamal vancomycininducedmaturationarrestwithreactivepromyelocyteproliferationadiagnosticandtherapeuticchallenge AT shuchismitashuchismita vancomycininducedmaturationarrestwithreactivepromyelocyteproliferationadiagnosticandtherapeuticchallenge AT vijayanandchoudhary vancomycininducedmaturationarrestwithreactivepromyelocyteproliferationadiagnosticandtherapeuticchallenge |