Isolinderalactone Induces Cell Death via Mitochondrial Superoxide- and STAT3-Mediated Pathways in Human Ovarian Cancer Cells

Isolinderalactone Induces Cell Death via Mitochondrial Superoxide- and STAT3-Mediated Pathways in Human Ovarian Cancer Cells

The mortality rate of ovarian cancer (OC) worldwide increases with age. OC is an often fatal cancer with a curative rate of only 20–30%, as symptoms often appear after disease progression. Studies have reported that isolinderalactone (ILL), a furanosesquiterpene derivative extracted from the dried r...

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Bibliographic Details
Main Authors: Shakya Rajina, Woo Jean Kim, Jung-Hyun Shim, Kyung-Soo Chun, Sang Hoon Joo, Hwa Kyoung Shin, Seo-Yeon Lee, Joon-Seok Choi
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
isolinderalactone
ovarian cancer
mitochondrial superoxide
janus kinase
signal transducer and activator of transcription 3
Online Access:https://www.mdpi.com/1422-0067/21/20/7530

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