Cell Responsiveness to Physical Energies: Paving the Way to Decipher a Morphogenetic Code
We discuss emerging views on the complexity of signals controlling the onset of biological shapes and functions, from the nanoarchitectonics arising from supramolecular interactions, to the cellular/multicellular tissue level, and up to the unfolding of complex anatomy. We highlight the fundamental...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-03-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/6/3157 |
| _version_ | 1797470971222818816 |
|---|---|
| author | Riccardo Tassinari Claudia Cavallini Elena Olivi Federica Facchin Valentina Taglioli Chiara Zannini Martina Marcuzzi Carlo Ventura |
| author_facet | Riccardo Tassinari Claudia Cavallini Elena Olivi Federica Facchin Valentina Taglioli Chiara Zannini Martina Marcuzzi Carlo Ventura |
| author_sort | Riccardo Tassinari |
| collection | DOAJ |
| description | We discuss emerging views on the complexity of signals controlling the onset of biological shapes and functions, from the nanoarchitectonics arising from supramolecular interactions, to the cellular/multicellular tissue level, and up to the unfolding of complex anatomy. We highlight the fundamental role of physical forces in cellular decisions, stressing the intriguing similarities in early morphogenesis, tissue regeneration, and oncogenic drift. Compelling evidence is presented, showing that biological patterns are strongly embedded in the vibrational nature of the physical energies that permeate the entire universe. We describe biological dynamics as informational processes at which physics and chemistry converge, with nanomechanical motions, and electromagnetic waves, including light, forming an ensemble of vibrations, acting as a sort of control software for molecular patterning. Biomolecular recognition is approached within the establishment of coherent synchronizations among signaling players, whose physical nature can be equated to oscillators tending to the coherent synchronization of their vibrational modes. Cytoskeletal elements are now emerging as senders and receivers of physical signals, “shaping” biological identity from the cellular to the tissue/organ levels. We finally discuss the perspective of exploiting the diffusive features of physical energies to afford in situ stem/somatic cell reprogramming, and tissue regeneration, without stem cell transplantation. |
| first_indexed | 2024-03-09T19:42:58Z |
| format | Article |
| id | doaj.art-fd69cd5fc4e44726a4b03bc336430214 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T19:42:58Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fd69cd5fc4e44726a4b03bc3364302142023-11-24T01:33:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01236315710.3390/ijms23063157Cell Responsiveness to Physical Energies: Paving the Way to Decipher a Morphogenetic CodeRiccardo Tassinari0Claudia Cavallini1Elena Olivi2Federica Facchin3Valentina Taglioli4Chiara Zannini5Martina Marcuzzi6Carlo Ventura7ELDOR LAB, National Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, CNR, Via Gobetti 101, 40129 Bologna, ItalyELDOR LAB, National Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, CNR, Via Gobetti 101, 40129 Bologna, ItalyELDOR LAB, National Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, CNR, Via Gobetti 101, 40129 Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyELDOR LAB, National Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, CNR, Via Gobetti 101, 40129 Bologna, ItalyELDOR LAB, National Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, CNR, Via Gobetti 101, 40129 Bologna, ItalyINBB, Biostructures and Biosystems National Institute, Viale Medaglie d’Oro 305, 00136 Rome, ItalyELDOR LAB, National Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, CNR, Via Gobetti 101, 40129 Bologna, ItalyWe discuss emerging views on the complexity of signals controlling the onset of biological shapes and functions, from the nanoarchitectonics arising from supramolecular interactions, to the cellular/multicellular tissue level, and up to the unfolding of complex anatomy. We highlight the fundamental role of physical forces in cellular decisions, stressing the intriguing similarities in early morphogenesis, tissue regeneration, and oncogenic drift. Compelling evidence is presented, showing that biological patterns are strongly embedded in the vibrational nature of the physical energies that permeate the entire universe. We describe biological dynamics as informational processes at which physics and chemistry converge, with nanomechanical motions, and electromagnetic waves, including light, forming an ensemble of vibrations, acting as a sort of control software for molecular patterning. Biomolecular recognition is approached within the establishment of coherent synchronizations among signaling players, whose physical nature can be equated to oscillators tending to the coherent synchronization of their vibrational modes. Cytoskeletal elements are now emerging as senders and receivers of physical signals, “shaping” biological identity from the cellular to the tissue/organ levels. We finally discuss the perspective of exploiting the diffusive features of physical energies to afford in situ stem/somatic cell reprogramming, and tissue regeneration, without stem cell transplantation.https://www.mdpi.com/1422-0067/23/6/3157physical energiesmechanical vibrationelectric fieldselectromagnetic radiationmicrotubulimorphogenesis |
| spellingShingle | Riccardo Tassinari Claudia Cavallini Elena Olivi Federica Facchin Valentina Taglioli Chiara Zannini Martina Marcuzzi Carlo Ventura Cell Responsiveness to Physical Energies: Paving the Way to Decipher a Morphogenetic Code International Journal of Molecular Sciences physical energies mechanical vibration electric fields electromagnetic radiation microtubuli morphogenesis |
| title | Cell Responsiveness to Physical Energies: Paving the Way to Decipher a Morphogenetic Code |
| title_full | Cell Responsiveness to Physical Energies: Paving the Way to Decipher a Morphogenetic Code |
| title_fullStr | Cell Responsiveness to Physical Energies: Paving the Way to Decipher a Morphogenetic Code |
| title_full_unstemmed | Cell Responsiveness to Physical Energies: Paving the Way to Decipher a Morphogenetic Code |
| title_short | Cell Responsiveness to Physical Energies: Paving the Way to Decipher a Morphogenetic Code |
| title_sort | cell responsiveness to physical energies paving the way to decipher a morphogenetic code |
| topic | physical energies mechanical vibration electric fields electromagnetic radiation microtubuli morphogenesis |
| url | https://www.mdpi.com/1422-0067/23/6/3157 |
| work_keys_str_mv | AT riccardotassinari cellresponsivenesstophysicalenergiespavingthewaytodecipheramorphogeneticcode AT claudiacavallini cellresponsivenesstophysicalenergiespavingthewaytodecipheramorphogeneticcode AT elenaolivi cellresponsivenesstophysicalenergiespavingthewaytodecipheramorphogeneticcode AT federicafacchin cellresponsivenesstophysicalenergiespavingthewaytodecipheramorphogeneticcode AT valentinataglioli cellresponsivenesstophysicalenergiespavingthewaytodecipheramorphogeneticcode AT chiarazannini cellresponsivenesstophysicalenergiespavingthewaytodecipheramorphogeneticcode AT martinamarcuzzi cellresponsivenesstophysicalenergiespavingthewaytodecipheramorphogeneticcode AT carloventura cellresponsivenesstophysicalenergiespavingthewaytodecipheramorphogeneticcode |