17β-estradiol inhibits TGF-β-induced collagen gel contraction mediated by human Tenon fibroblasts via Smads and MAPK signaling pathways

17β-estradiol inhibits TGF-β-induced collagen gel contraction mediated by human Tenon fibroblasts via Smads and MAPK signaling pathways

AIM: To investigate the impact of 17β-estradiol on the collagen gels contraction (CGC) and inflammation induced by transforming growth factor (TGF)-β in human Tenon fibroblasts (HTFs). METHODS: HTFs were three-dimensionally cultivated in type I collagen-generated gels with or without TGF-β (5 ng/mL)...

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Bibliographic Details
Main Authors: Cheng-Cheng Yang, Meng-Jie Liu, Yun-Ze-Peng Li, Zheng-Hua Xu, Yang Liu, Zi-Han Guo, Bin-Hui Li, Xiu-Xia Yang
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2023-09-01
Series:International Journal of Ophthalmology
Subjects:
tenon fibroblasts
transforming growth factor-β
17β-estradiol
fibrosis
wound healing
Online Access:http://ies.ijo.cn/en_publish/2023/9/20230910.pdf

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