The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans
The question as to how the soma regulates the germline has been much studied. Here, the authors show in C. elegans that the poly-U specific endoribonuclease ENDU-2 is secreted from the soma and taken-up by the germline, binding mature mRNA, repressing expression of somatic transcripts and maintainin...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21516-6 |
| _version_ | 1818722380008128512 |
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| author | Wenjing Qi Erika D. V. Gromoff Fan Xu Qian Zhao Wei Yang Dietmar Pfeifer Wolfgang Maier Lijiang Long Ralf Baumeister |
| author_facet | Wenjing Qi Erika D. V. Gromoff Fan Xu Qian Zhao Wei Yang Dietmar Pfeifer Wolfgang Maier Lijiang Long Ralf Baumeister |
| author_sort | Wenjing Qi |
| collection | DOAJ |
| description | The question as to how the soma regulates the germline has been much studied. Here, the authors show in C. elegans that the poly-U specific endoribonuclease ENDU-2 is secreted from the soma and taken-up by the germline, binding mature mRNA, repressing expression of somatic transcripts and maintaining germline immortality. |
| first_indexed | 2024-12-17T20:53:42Z |
| format | Article |
| id | doaj.art-fd6af941845e499489ea04b3d6fe0d66 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T20:53:42Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fd6af941845e499489ea04b3d6fe0d662022-12-21T21:32:57ZengNature PortfolioNature Communications2041-17232021-02-0112111210.1038/s41467-021-21516-6The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegansWenjing Qi0Erika D. V. Gromoff1Fan Xu2Qian Zhao3Wei Yang4Dietmar Pfeifer5Wolfgang Maier6Lijiang Long7Ralf Baumeister8Bioinformatics and Molecular Genetics (Faculty of Biology), Albert-Ludwigs-University FreiburgBioinformatics and Molecular Genetics (Faculty of Biology), Albert-Ludwigs-University FreiburgBioinformatics and Molecular Genetics (Faculty of Biology), Albert-Ludwigs-University FreiburgBioinformatics and Molecular Genetics (Faculty of Biology), Albert-Ludwigs-University FreiburgBioinformatics and Molecular Genetics (Faculty of Biology), Albert-Ludwigs-University FreiburgDepartment of Hematology, Oncology and Stem Cell Transplantation, Medical Center-University of Freiburg, Faculty of Medicine, University of FreiburgBioinformatics and Molecular Genetics (Faculty of Biology), Albert-Ludwigs-University FreiburgBioinformatics and Molecular Genetics (Faculty of Biology), Albert-Ludwigs-University FreiburgBioinformatics and Molecular Genetics (Faculty of Biology), Albert-Ludwigs-University FreiburgThe question as to how the soma regulates the germline has been much studied. Here, the authors show in C. elegans that the poly-U specific endoribonuclease ENDU-2 is secreted from the soma and taken-up by the germline, binding mature mRNA, repressing expression of somatic transcripts and maintaining germline immortality.https://doi.org/10.1038/s41467-021-21516-6 |
| spellingShingle | Wenjing Qi Erika D. V. Gromoff Fan Xu Qian Zhao Wei Yang Dietmar Pfeifer Wolfgang Maier Lijiang Long Ralf Baumeister The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans Nature Communications |
| title | The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans |
| title_full | The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans |
| title_fullStr | The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans |
| title_full_unstemmed | The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans |
| title_short | The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans |
| title_sort | secreted endoribonuclease endu 2 from the soma protects germline immortality in c elegans |
| url | https://doi.org/10.1038/s41467-021-21516-6 |
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